Category Archives: Avant Diagnostics Inc. AVDX

Avant Diagnostics, Inc. (AVDX) Aims to Cut Costs and Deliver Fast Results with Ovarian Cancer Detection Test

March 2, 2016

Avant Diagnostics, Inc. (OTCQB: AVDX) is a medical technology company that focuses its efforts on the human genome project. This genetic research continues to delve deeper into identifying variations of specific genes in the genome. A genome is all of the genes that make up a cell or organism. It’s basically a recipe book on how to build a human. Variations in these genes allow scientists to see individual characteristics of disease states and a person’s propensity for them. Scientists are then able to detect diseases earlier, thereby providing early treatment, which improves a patient’s quality of life while preventing disease progression. Avant Diagnostics is a key contributor to this program by developing its own advanced technology that identifies early stage ovarian cancer. This early detection can both decrease medical costs and increase samples while producing faster results.

Avant Diagnostic’s OvaDxⓇ is a microarray-based test that measures the immune system’s response to early stage ovarian cancer tumor cells in blood samples. Impressively, this is the market’s first large panel screening test for the disease. The test has a high sensitivity for all stages of ovarian cancer and eliminates false negatives and false positives. Plus, the proteomic panel provides real-time results, speeding up the process towards treatment if necessary.

To further stand by its aim of creating testing with fast results, Avant Diagnostics will soon merge with Amarantus Diagnostics, a biotechnology firm that develops diagnostic tests for neurological diseases. This partnership has a high potential of delivering diagnosis and monitoring tools for early detection at an even faster rate.

Not only does OvaDxⓇ deliver fast results, but it cuts costs in the overall treatment of ovarian cancer for patients and health centers. According to Current Women’s Health Reviews, late-stage ovarian cancer treatment could cost at least $210,000 or more. With early detection, a patient can get affordable treatment for the disease that has not progressed as far as it could.

Avant Diagnostics intends to make its product available as soon as possible, so women can be aware of their own ovarian cancer risks. With accurate and fast results, the company offers women the chance at early treatment to prevent expensive costs and painful therapy down the road.

For more information, visit the company website at www.avantdiagnostics.com

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Avant Diagnostics, Inc. (AVDX) Participating in the ‘War on Cancer’ With Preventative Early Detection Technology

February 25, 2016

Ovarian cancer is the fourth-leading cause of cancer deaths among women in the U.S. When someone is diagnosed with ovarian cancer, they are usually in the advanced stages of the disease and treatment is not nearly as effective as it would be if it had been discovered earlier. Avant Diagnostics, Inc. (OTCQB: AVDX) is a medical diagnostic technology company that specializes in large panel biomarker screening. The company’s first test, OvaDx®, is a sophisticated microarray-based test designed to detect pre-symptomatic ovarian cancer by measuring the activation of the immune system in blood samples in response to early stage ovarian tumor cell development.

In clinical development, OvaDx has indicated high sensitivity and specificity for all types and stages of ovarian cancer, including stage IA-IV borderline serous, clear cell, endometrioid, mixed epithelial, mucinous, serous and ovarian adenocarcinoma. Upon FDA approval, Avant plans to offer its diagnostic product as an elective test for women seeking greater wellness, as well as those in the elevated risk category for ovarian cancer.

In a recent Time magazine article (http://dtn.fm/sv0Pa), there is a great comparison study done on a largely ineffective technique currently used for early detection of ovarian cancer. A blood test, called CA-125, can pick up signs of tumors in the ovaries, but it’s not very specific or sensitive for these growths. CA-125 levels can rise not just because of ovarian tumors, but during menstruation and pregnancy as well. That may explain why the test only picks up 60% to 65% of cancers.

OvaDx is expected to be used by doctors to advance the forefront of ovarian cancer treatment, promoting the utilization of improved surgical options and more effective chemotherapies by serving as a supplement to existing tests, such as CA-125, OVA1® and transvaginal ultrasound. In this way, Avant’s innovative product will promote earlier diagnoses and, as a result, improved survival rates for patients with ovarian cancer.

According to another Time magazine article (http://dtn.fm/J1Vwa), the traditional treatment for ovarian cancer is surgery followed by rounds of monthly chemotherapy. The treatment is effective, but there is growing evidence that exposing tumors to such high dose toxic agents at one time is effective in killing cancer cells in the short term, but may encourage chemo-resistant cells to flourish over time.

The common theme here is that early identification of problems (ovarian cancer in this case) is essential in order to take full advantage of currently available treatment options. Cancer is just like the ‘The Blob’ from the classic 1950’s movie and the 1980’s remake. If people would have properly identified the Blob/cancer earlier, it could have been frozen/treated and stored away so that people could have gone on with their daily lives without worry and pain.

For more information, visit the company website at www.avantdiagnostics.com

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Avant Diagnostics, Inc. (AVDX) Presenting at the SeeThruEquity & The Brewer Group 2nd Annual Innovations Investor Conference

February 19, 2016

Earlier today, Avant Diagnostics, Inc. (OTCQB: AVDX) announced that it will present at the SeeThruEquity & The Brewer Group 2nd Annual Innovations Investor Conference, which will take place at The Ritz-Carlton in Miami on South Beach on February 22, 2016. As a presenter, Avant will be provided with a 30-minute time slot with which to present to an audience of investors and industry professionals. The company’s management team is also expected to be available for one-on-one meetings with institutional investors attending the event.

To view a complete list of presenting companies, visit http://steconference.com/presenting-companies

This announcement follows last month’s news that Avant has entered into a letter of intent to merge with Amarantus Diagnostics, a wholly-owned subsidiary of Amarantus Bioscience Holdings, Inc. (OTCQX: AMBS). The proposed merger is expected to create opportunities for the combined company to progress the development of highly valuable diagnostic assets – including Avant’s OvaDx® large panel biomarker test for use in monitoring women at a heightened risk for ovarian cancer, as well as Amarantus Diagnostics’ MSPrecise® diagnostic assay for multiple sclerosis and LymPro Test® flow cytometry assay for Alzheimer’s disease.

“After exploring numerous avenues for implementing Avant’s OvaDx® development and commercialization strategy, it is clear that combining Avant’s and Amarantus’ diagnostic assets and core competencies forms a platform that provides maximum value to our collective shareholders,” Gregg Linn, president and chief executive officer of Avant, stated in a recent news release. “The collective diagnostic assets will create a truly unique opportunity to implement our respective missions of saving and enhancing lives through early detection of disease in oncology and neurology.”

SeeThruEquity, a leading independent equity research and corporate access firm, released a report studying the potential effects of the Avant merger last month. Among the highlights, the SeeThruEquity report inferred that, when completed, the proposed merger “will allow them to progress at a much faster pace and to develop valuable diagnostic assets in areas of oncology and neurology.” The report went on to note that the combined assets of Avant and Amarantus Diagnostics “have the potential to improve the practice of medicine by providing new proprietary diagnosis and monitoring tools for oncologists and neurologists.”

If approved for commercialization, OvaDX, in particular, is expected to offer a clear improvement to the current diagnostic standard by substantially improving the accuracy of diagnosis and allowing for a more effective therapeutic triaging and intervention strategy. It’s estimated that the market opportunity for OvaDx is $50 million annually as a diagnostic test for ovarian cancer, and this opportunity would expand to over $2 billion annually if it were to be approved as a generalized screening and/or monitoring tool.

For more information, visit the company website at www.avantdiagnostics.com

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Avant Diagnostics (AVDX) Announces a Partnership of Promise with Amarantus Diagnostics

February 18, 2016

The recent announcement by Avant Diagnostics, Inc (OTCQB: AVDX) and Amarantus Bioscience Holdings, Inc (OTCQX: AMBS) of their intention to tie the knot is a message of cheer for women who may be at risk for ovarian cancer. It also promises a partnership that will aggressively pursue opportunities in the rapidly expanding molecular diagnostics (MDx) market. A summary (http://dtn.fm/w2IbO) of a report from industry consultants Grand View Research estimates global molecular diagnostics market size at over $4.8 billion in 2014 with the U.S. market accounting for over $2.0 billion of that, and, according to a story (http://dtn.fm/D86pl) in The Journal of Precision Medicine, Grand View Research predicts the market will grow ‘at a compound annual growth rate (CAGR) of 8.7 percent to hit $8.02 billion by 2020, up from $4.47 billion in 2013. The growth will largely be driven by the rapidly increasing focus on theranostics and precision medicine, as well as the continuing development of advanced cancer diagnostic technologies like next-generation sequencing.’ Theranostics and precision medicine describe therapies with an individualized approach.

A press release (http://dtn.fm/AfG4c) on the Amarantus website proclaimed the purpose of the proposed merger was to ‘assist Avant Diagnostics in bolstering its product development and commercialization resources to accelerate the monetization of the combined company’s product pipeline… by harnessing the power of biomarkers based in the immune system.’ So what is molecular diagnostic testing, and how does it go about harnessing the power of biomarkers?

Molecular diagnostic testing has become possible since the successful mapping of the genes of humans. Spanning a period of over a decade, the Human Genome Project (HGP), initiated in 1990, was an international research effort to sequence and map all of the genes – together known as the genome – of members of our species, Homo sapiens. Completed in April 2003, the HGP gave us the ability, for the first time, to read nature’s complete genetic blueprint for building a human being. Now armed with that knowledge, it is possible to be able to detect specific sequences in deoxyribonucleic acid (DNA) or ribonucleic acid (RNA) that may be associated with disease.

Employing these insights, Avant Diagnostics’ OvaDx is the first large panel biomarker monitoring test for ovarian cancer. It measures the activation of the immune system in blood samples in response to early stage ovarian tumor cell development. A biomarker is a biological molecule found in blood, other body fluids, or tissues that may signal an abnormal process or a disease. A biomarker, also called a molecular marker or a signature molecule, may also be used to see how well the body responds to a treatment for a disease or condition.

The molecular diagnostics space has seen a lot of activity in recent times. A story (http://dtn.fm/npFh5) in GEN states that many startup MDx companies, especially the ones engaged in cancer detection, have been snapped up by the big boys. Roche (OTCQX: RHHBY) has been particularly spendthrifty. Last year, it acquired a majority stake in Foundation Medicine (NASDAQ: FMI) for $1.18 billion. The pharmaceutical giant also paid around $625 million for Ariosa Diagnostics, another $450 million for Iquum, $350 million for Genia Technologies and an undisclosed sum for Signature Diagnostics.

Roche wasn’t the only large player to jump into the fray. In 2014, Veracyte (NASDAQ: VCYT) purchased Allegro Diagnostics for $21 million; Myriad Genetics (NASDAQ: MYGN) bought Crescendo Bioscience for $245 million; bioMérieux (OTC: BMXMF) bought BioFire Diagnostics for $486 million and Rosetta Genomics (NASDAQ: ROSG) purchased PersonalizeDx for $2 million in cash plus stock. Large companies like Roche, Qiagen (NASDAQ: QGEN), Becton Dickinson (NYSE: BDX) and Abbott (NYSE: ABT) have recognized the potential of the MDx market. They’re looking for companies like Avant and Amarantus to unlock value. Soon, it may be time to put out the welcome mat.

For more information, visit the company website at www.avantdiagnostics.com

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Avant Diagnostics (AVDX): Early Detection of Ovarian Cancer Increases Survival Rates by Five Times

February 9, 2016

The American Cancer Society estimates that in 2016, about 22,280 new cases of ovarian cancer will be diagnosed and 14,240 women will die of ovarian cancer in the U.S. Mortality rates for ovarian cancer have declined only slightly in the forty years since the “War on Cancer” was declared. However, other cancers have shown a much greater reduction in mortality, due to the availability of early detection tests and improved treatments. The Surveillance, Epidemiology and End Results (SEER) Program reported that in 2012 in the U.S. approximately 192,446 women were alive who had been diagnosed with ovarian cancer (including those who had been cured of the disease).

Early detection of cancer is the key to using the medicines available today to battle cancer and give the patient the best chance of beating this horrible disease and getting back to a normal life. Avant Diagnostics, Inc. (OTCQB: AVDX) has undertaken this heroic challenge with its OvaDx Pre-Symptomatic Ovarian Cancer Screening Test.

OvaDx is a sophisticated microarray-based test that measures the activation of the immune system in blood samples in response to early stage ovarian tumor cell development. Upon commercialization, it’s estimated that the market opportunity for OvaDX could be $50 million annually as a diagnostic test for ovarian cancer, and it could expand to over $2 billion if the test were to be approved as a generalized screening and/or monitoring tool.

Some form of cancer has affected almost every family in the U.S. either personally or through a member of their immediate family. The common denominator between cancer and any ailment is that the earlier it is detected, the better your chances of survival. Continual monitoring of treatment coupled with early detection can better the odds significantly and prolong your lifespan. If someone gets tested regularly and detects ovarian cancer early, their five-year survival rate is 93 percent compared to a five-year survival rate of only 18 percent if detected in the later stages.

For more information, visit the company website at www.avantdiagnostics.com

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Avant Diagnostics, Inc. (AVDX) Positioned to Expand Clinical Pipeline following Entry into Letter of Intent to Merge with Amarantus Diagnostics

February 2, 2016

Late last month, Avant Diagnostics, Inc. (OTCQB: AVDX) made headlines when it announced plans to merge with Amarantus Diagnostics, a wholly-owned subsidiary of Amarantus Bioscience Holdings, Inc. (OTCQX: AMBS). Under the terms of the previously announced Letter of Intent, Avant will issue 80 million shares of common stock to Amarantus upon execution of definitive merger agreements, which will represent roughly 45 percent of Avant’s post-merger common stock. An additional 10 million shares of common stock will be transferred upon achievement of predetermined sales milestones. According the company’s news release, the transaction is expected to be finalized in the second quarter of 2016, setting the stage for tremendous opportunities to progress Avant’s highly valuable diagnostic assets in the areas of oncology and neurology.

“After exploring numerous avenues for implementing Avant’s OvaDx® development and commercialization strategy, it is clear that combining Avant’s and Amarantus’ diagnostic assets and core competencies forms a platform that provides maximum value to our collective shareholders,” Gregg Linn, president and chief executive officer of Avant, stated in a news release.

The operational synergies between the two companies are expected to create significant opportunities for financial growth following completion of the proposed merger. Both Amarantus Diagnostics and Avant possess assets with the potential to provide early and actionable information to physicians and researchers by harnessing the power of biomarkers based in the immune system in disease areas that previously yielded results of limited value. Avant’s OvaDx® immuno-oncology diagnostic assay, for example, represents a significant improvement in the screening and diagnosis of ovarian cancer. Upon commercialization, it’s estimated that the market opportunity for OvaDX could be $50 million annually as a diagnostic test for ovarian cancer, and it could expand to over $2 billion if the test were to be approved as a generalized screening and/or monitoring tool.

“The collective diagnostic assets will create a truly unique opportunity to implement our respective missions of saving and enhancing lives through early detection of disease in oncology and neurology,” continued Linn. “The combined companies will enjoy additional benefits by creating a compelling platform to showcase the power diagnostics have to reduce costs and improve outcomes in the healthcare system.”

Amarantus Diagnostics’ development pipeline is expected to have similarly expansive market potential upon commercial approval. Its MSPrecise® neuroimmunology-based next-generation sequencing diagnostic assay for multiple sclerosis (MS), which is expected to greatly improve the diagnostic accuracy rate in MS while reducing costs for payers, will target a $200 million market, with the potential to address additional markets as a monitoring tool to measure the efficacy of drug treatment over time. Amarantus is also developing its innovative LymPro Test®, a neuroimmunology-based flow cytometry assay, for the early detection of Alzheimer’s disease.

Gerald E. Commissiong, president and chief executive officer of Amarantus, summarized the two companies’ optimism regarding the tremendous commercial potential of the merged company in a recent news release.

“We believe that combining these state-of-the-art technologies with a deep understanding of chronic disease rooted in immunology will produce a world-class diversified immuno-oncology and neuroimmunology focused diagnostics company able to deliver actionable information to physicians seeking to provide the most tailored treatment options for patients, while also assisting the research community in developing new medicines for these devastating disorders,” he said.

For more information, visit the company website at www.avantdiagnostics.com

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Avant Diagnostics (AVDX): Battling Ovarian Cancer with Its Early Detection OvaDx Test

January 29, 2016

Ovarian cancer is a deadly disease and should be taken seriously. Early detection and monitoring of tumor development is the key to survival. If someone gets tested regularly and detects ovarian cancer early, their five-year survival rate can be as high as 93 percent, compared to a five-year survival rate of only 18 percent if detected in the later stages. Avant Diagnostics, Inc. (OTCQB: AVDX) is a medical diagnostic technology company that specializes in large panel biomarker screening. The company’s first test, OvaDx, is a sophisticated microarray-based test designed to detect pre-symptomatic ovarian cancer by measuring the activation of the immune system in blood samples in response to early stage ovarian tumor cell development.

According to the American Cancer Society, more than 21,300 women were diagnosed with ovarian cancer last year, ultimately leading to 14,200 deaths. With early detection, your chances obviously improve, as mentioned above, so making the OvaDx test part of your annual checkup should be a no-brainer. Considering the ramifications of just going with the flow and cutting corners on regular monitoring of tumor development during the treatment process, one would ascertain that constant observation of which drugs are working and how well they are working would be greatly beneficial to the patient.

The ovarian cancer diagnostic market, where Avant Diagnostics competes, is worth more than $2 billion. With innovative, necessary testing procedures like OvaDx, the company is positioned to become a major game changer upon FDA approval. Some of the major players engaged in personalized medicine and molecular diagnostics involving biomarkers are global microarray market leader Affymetrix (NASDAQ: AFFX), which was recently reported as having been acquired by competitor Thermo Fisher Scientific (NYSE: TMO) for approximately $1.3 billion.

The standard approach to ovarian cancer utilizes the combination of a platinum compound, such as Bristol-Myers Squibb’s (NYSE: BMY) Platinol (cisplatin) or Paraplatin (carboplatin), and a Taxane, such as Sanofi’s (NYSE: SNY) Taxotere (docetaxel) or Phyton Biotech’s Taxol (paclitaxel). However, for patients with platinum-resistant/refractory ovarian cancer, early detection is really the brass ring, even with such good news out recently as Merck (NYSE: MRK) and Pfizer (NYSE: PFE) receiving FDA approval for the first Phase III study of avelumab, an investigational, fully human PD-L1 (programmed death-ligand 1) inhibitor that could emerge as a treatment for platinum-resistant/refractory ovarian cancer.

For more information, visit the company website at www.avantdiagnostics.com

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Avant Diagnostics (AVDX): Trials and Tribulations

January 21, 2016

Recently, in Avant Diagnostics set to exploit new opportunities in the laboratory testing market (http://dtn.fm/hg8TK), we reported that ‘OvaDx is now undergoing 510K trials.’ It seems we jumped the gun. We reached out to Avant’s CEO, Gregg Linn, to get clarification on our report and he confirmed that the OvaDx approval process hasn’t reached the 510K trial stage yet. Avant has been engaged in the calibration testing and validation study phases regarding OvaDx and it expects the 510K trials to commence this year. In September 2015, Avant began calibration testing in preparation for the validation study of OvaDx, which will be used to support a pre-Submission package to the United States Food and Drug Administration (FDA).

Upon completion of the calibration testing, Avant plans to test the previously purchased set of ovarian cancer specimens, including serial sets obtained from women diagnosed previously with ovarian cancer. The tests on the ovarian cancer specimens will serve as the validation study and form the basis of the pre-Submission package delivered to the FDA for review and comment prior to the commencement of the OvaDx 510(k) trial.

The OvaDx microarray test is intended for use as an aid in monitoring women diagnosed previously with ovarian cancer. The validation study and 510(k) trial will be conducted in a double-blinded environment supervised by DOCRO, Inc., an independent clinical research organization. In a double-blinded environment, neither the researchers nor the subjects participating have knowledge of whether a procedure administered is an actual test or simply a control.

The results from the validation study are expected to be published in a peer-reviewed scientific journal within six months of test completion and data analysis. 510K trials will commence after the validation study is completed. A 510(K) is a pre-market submission made to the FDA to demonstrate that the device to be marketed is at least as safe and effective as a legally marketed device. Avant believes the OvaDx test has an advantage over Roche’s CA-125 test and Vermillion’s Ova 1 test.

In October 2015, Avant received notification, through its independent clinical research organization, DOCRO, that the previously purchased specimens have been approved and are available for use in the validation study.

As seen in recent news releases, the OvaDx approval process is alive and well. And Avant is reaching out to the investor community to tell them so. Gregg Linn will be one of the speakers at the Noble Financial Capital Markets’ Twelfth Annual Investor Conference (NobleCon12) in Sandpiper Bay, Florida, on Tuesday, January 19, 2016.

From January 22, 2016, a high-definition video web-cast of Gregg’s presentation and a copy of the presentation materials will be available on the Avant Diagnostics website and as part of a complete catalog of presentations available at Noble Financial websites: www.noblefcm.com, or www.nobleconference.com.

For more information, visit the company website at www.avantdiagnostics.com

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Avant Diagnostics, Inc. (AVDX) Ovarian Cancer Early Detection Diagnostic Tech Bolstered Mightily By Amarantus Bioscience Merger

According to recent analysis out late last year from the world’s second largest publisher of premium market reports, MarketsandMarkets, the global market for biomarkers is on-track to grow at a CAGR of 13.58 percent through 2020, reaching upwards of $45.55 billion on the strength of increasing healthcare, as well as R&D spending. A key driver of this growth is the massive importance of biomarkers as an objective means for calculating a pathogenic or pharmacological response to therapeutics, or to gauge the behavior of a normal biological process. Biomarker technology continues to play a pivotal role when it comes to developing cutting-edge diagnostics for ailments such as cancer.

Indeed, the global cancer biomarkers market will continue to be one of the most active segments moving forward according to M&M, and this segment is slated to run at an 11.6 percent CAGR over the same interval. Driven by major players engaged in personalized medicine and molecular diagnostics involving biomarkers, such as global microarray market leader Affymetrix (NASDAQ: AFFX), which was recently reported as having been acquired by competitor Thermo Fisher Scientific (NYSE: TMO) for approximately $1.3 billion, as well as more investor-accessible players, some of whom may have at their disposal technologies that hold the potential to reshape the industry itself.

Such high-profile M&A activity at the heart of the translational research/microarray sector speaks volumes for how hot the space has become, and how much promise it holds for the future of medicine. One of the areas in oncology diagnostics that bears consideration is ovarian cancer, due to the specific challenges and concerns associated with the space. American Cancer Society data indicates that roughly 21,300 women in the U.S. alone were diagnosed with ovarian cancer last year, leading to approximately 14,200 tragic deaths. With an overall five-year survival rate of only 45 percent, ovarian cancer is the fifth most common cause of cancer-related death among women, and the risk is highest in women over the age of 55.

Given the high five-year survivability rate of around 93 percent for ovarian cancer, if it is detected in the early stage in which the symptoms are often ignored – compared to an only 18 percent five-year survivability rate if it is detected in later stages – the benefits of advanced warning and pre-symptomatic screening using a definitive, cost-effective diagnostic test cannot be overstated. This is especially true for patients who are found to have platinum-resistant/refractory ovarian cancer, as such patients have an extremely poor prognosis and may also be classed as having chemotherapy-resistant/refractory ovarian cancer.

The standard approach to ovarian cancer utilizes the combination of a platinum compound such as Bristol-Myers Squibb’s (NYSE: BMY) (OTC: BMYMP) Platinol® (cisplatin) or Paraplatin® (carboplatin), and a Taxane, such as Sanofi’s (NYSE: SNY) Taxotere® (docetaxel), or Phyton Biotech’s Taxol® (paclitaxel). But for patients with platinum-resistant/refractory ovarian cancer, early detection is really the brass ring, even with such good news out recently as Merck (NYSE: MRK) and Pfizer (NYSE: PFE) receiving FDA approval for the first Phase III study of avelumab, an investigational, fully human PD-L1 (programmed death-ligand 1) inhibitor that could emerge as a treatment for platinum-resistant/refractory ovarian cancer.

Suffice it to say, this is a market ripe for a simplified microarray-based blood test for early detection of ovarian cancer, including tests like Avant Diagnostics’ (OTCQB: AVDX) OvaDx®, which possesses numerous advantages over the standard CA 125 protein biomarker test for ovarian cancer. Advantages include a sample size of only a few drops and the elimination of needle blood draws, factors which allow for high-volume screening throughput at even smaller facilities. A simplified test like OvaDx, which uses sample shipping and storage on room temperature blood cards and nevertheless yields definitive diagnostic results that allow for detection of early stage ovarian tumor cell development, is a real triumph for women’s health. OvaDx could be a game changer for the $2 billion plus ovarian cancer diagnostic market and might just put AVDX in the immuno-oncology pole position.

The recent announcement that AVDX has entered into an LOI with regenerative medicine, neurology and orphan disease-focused Amarantus Bioscience Holdings (OTCQX: AMBS) to merge the wholly-owned diagnostics subsidiary of Amarantus into AVDX is further proof of how hot the sector is overall. Amarantus Diagnostics’ MSPrecise®, a neuroimmunology-based sequencing assay for multiple sclerosis, also adds mightily to AVDX’s already promising diagnostics footprint. The $1 billion market potential possible in addressing the woefully inaccurate diagnostics market for multiple sclerosis stands to make the combined company a force to be reckoned with. Adding to this emerging diagnostic juggernaut’s appeal is the $3 billion potential of Amarantus Diagnostics’ LymPro Test® for Alzheimer’s disease, another early detection-focused marvel that could revolutionize treatment options for Alzheimer’s patients.

For more information, visit www.avantdiagnostics.com

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Avant Diagnostics, Inc. (AVDX) Announces Letter of Intent to Merge with Diagnostics Division of Amarantus Bioscience Holdings, Inc.

January 19, 2016

Earlier today, Avant Diagnostics, Inc. (OTCQB: AVDX) announced that it has entered into a non-binding letter of intent to merge with Amarantus Diagnostics, a wholly-owned subsidiary of Amarantus Bioscience Holdings, Inc. (OTCQX: AMBS). Under the terms of the agreement, Avant will issue 80 million shares of common stock to Amarantus upon execution of definitive agreements, as well as additional shares of common stock after reaching predetermined sales milestones. The transaction is subject to customary closing conditions, and it’s expected to be finalized in the second quarter of 2016.

“We are pleased to have found the appropriate partner to divest our diagnostics business unit as we transition to a therapeutics-only focused company,” Gerald E. Commissiong, president and chief executive officer of Amarantus, stated in the news release. “After exploring numerous avenues for implementing Avant’s OvaDx® development and commercialization strategy, it is clear that combining Avant’s and Amarantus’ diagnostic assets and core competencies creates a platform that provides maximum value to our collective shareholders.”

Avant’s OvaDx is a sophisticated microarray-based test offering the potential to substantially improve the current diagnostic standards related to ovarian cancer. By combining this powerful, protein-based technology with the therapeutic pipeline of Amarantus Diagnostics, Avant aims to establish itself as a world-class diversified neurology- and oncology-focused diagnostics company with the ability to deliver actionable information to physicians seeking to provide the best treatment options for patients, as well as to assist the research community in developing new treatments for a host of devastating illnesses.

The foundation of this merger agreement is the intrinsic connection between the fundamental scientific underpinnings of Avant’s oncology research and Amarantus’s research in the fields of neurodegeneration. By pooling protein-based, flow-based and next-gen sequencing based technologies, the combined company’s diagnostic testing portfolio is expected to greatly expand Avant’s ability to evaluate cross-platform development of diagnostic products.

“The collective diagnostic assets [of Avant and Amarantus Diagnostics] will create a truly unique opportunity to implement our mission of saving and enhancing lives through early detection of disease,” continued Commissiong. “We expect that the sum of the collective parts will far exceed the value of the individual parts.”

Amarantus’s intellectual property portfolio includes NuroPro®, a protein-based diagnostic blood test for Parkinson’s disease; SeraPro BC, a protein-based diagnostic blood test for breast cancer; and several other assays that will be contributed to Avant following the successful completion of the merger. Additionally, Amarantus Diagnostics has entered into an agreement with a Maryland-based CLIA laboratory in preparation for CLIA-enabling validation studies, and, following completion of the merger transaction, this agreement is expected to better position Avant to advance the clinical development of OvaDx.

For more information, visit www.avantdiagnostics.com

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Avant Diagnostics (AVDX) Set to Exploit New Opportunities in the Laboratory Testing Market

January 15, 2016

The laboratory testing market is huge. According to a study conducted by Quest Diagnostics, the largest clinical testing laboratory in the U.S., the laboratory testing market in the United States is approximately $50 billion. Of that, 60% is controlled by hospital-based laboratories. Another 35% of the market is held by independent clinical laboratories, and physician office laboratories (POLs) hold the remaining 5%. Within this $50 billion market, most of the testing performed is for routine lab tests (such as total cholesterol, pap testing and white blood cell count) and anatomic pathology tests. Anatomic pathology tests attempt to identify abnormalities in body organs that signal the advent of disease as opposed to the more routine procedures that test blood and other bodily fluids. However, recently there has been a dramatic increase in gene-based testing and molecular testing, which measure our susceptibilities to inherited diseases, and esoteric testing. Esoteric testing is a catchall term for more complex clinical tests.

In the vanguard of the forces advancing women’s health through these technologies marches Avant Diagnostics, Inc. (OTCQB: AVDX). Employing technology it has exclusively licensed from Wayne State University, the company has developed a microarray-based diagnostic test called OvaDx. OvaDx is the first large panel biomarker monitoring test for ovarian cancer. It measures the activation of the immune system in blood samples in response to early stage ovarian tumor cell development. A biomarker is simply an objective measure of the body’s functioning.

Microarrays have been described as the tracks of the global life sciences freight train. A microarray is a collection of DNA on a surface. They are sometimes referred to as biochips or DNA chips. In the forefront of microarray technology is the Arrayit Corporation (OTC: ARYC), and back in 2009, Avant entered into a Technology Transfer Agreement (TTA) with Arrayit. The TTA gave Avant exclusive license rights to all of Arrayit’s trade secrets and protocols required for the sale and use of the OvaDx ovarian cancer test. Arrayit Corporation is a leader in the microarray industry. It develops, manufactures and markets life science tools and integrated laboratory platforms for the analysis of genetic variation, biological function, and diagnostics. Arrayit also provides specialized equipment, tools, and microarray manufacturing services to more than 10,000 research laboratories, pharmaceutical companies, academic institutions, clinical research organizations, government agencies and biotechnology companies around the globe.

Microarrays have indeed proved to be a track to success, and at least three companies, Illumina, Inc. (NASDAQ: ILMN), Agilent Technologies, Inc. (NYSE: A) and Myriad Genetics, Inc. (NASDAQ: MYGN) have taken that track. Myriad deserves special mention. The company’s valuation rose spectacularly after it was revealed that Angelina Jolie had used Myriad’s diagnostic test, BRACAnalysis. BRACAnalysis determined that Jolie had an 87 percent risk of breast cancer and 50 percent chance of ovarian cancer because of an inherent genetic mutation. Miss Jolie has a defect in her BRACI genes. Those with a similar defect have, on average, a 65% chance of developing breast cancer. Myriad got its microarray technology from Arrayit, the same company that has given Avant access to its methodologies.

Avant is in the right place at the right time. The molecular diagnostics segment of the laboratory testing market is expected to reach $8 billion by the end of 2017. OvaDx will soon be undergoing 510(K) trials. A 510(K) is a pre-market submission made to the FDA to demonstrate that the device to be marketed is at least as safe and effective as a legally marketed device. Avant believes the OvaDx test has an advantage over Roche’s CA-125 test and Vermillion’s Ova 1 test. With its gene-based microarray OvaDX test, Avant is not only guarding our womenfolk, it’s poised to enjoy great financial success. It’s a classic case of having your cake and eating it, too.

For more information, visit www.avantdiagnostics.com

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Avant Diagnostics, Inc. (AVDX) Developing the Future of Ovarian Cancer Screenings

January 6, 2016

Ovarian cancer is the eighth most common form of cancer in the United States, according to the Centers for Disease Control and Prevention, and it’s the fifth leading cause of cancer deaths. This dangerous form of cancer begins as a growth of abnormal malignant cells in the ovaries before spreading to other sites within the body. Although we still don’t know exactly what causes ovarian cancers, we do know that some factors make women more likely to develop epithelial ovarian cancer during their lifetime. According to the American Cancer Society, both inherited genetic mutations and acquired genetic changes can place women at a heightened risk of developing this dangerous condition.

For women in an elevated risk category for ovarian cancer, regular screening and, if necessary, early detection can play a major role in overall health and wellbeing. If diagnosed in its early stages, ovarian cancer is an extremely survivability illness. When discovered in stage one, approximately 92 percent of ovarian cancer cases surpass the recorded five-year survival milestone. Despite this statistic, the average five-year survival rate for ovarian cancer is just 44 percent. This is because only 15 percent of ovarian cancers are currently diagnosed during stage one, according to Healthline.

Avant Diagnostics, Inc. (OTCQB: AVDX) is on a mission to improve the survivability of ovarian cancer by giving women access to more effective early detection technology. The company’s pre-symptomatic ovarian cancer screening test, OvaDx®, is a leading breakthrough in the field of ovarian cancer diagnostics. OvaDx is a sophisticated microarray-based test that measures the activation of the immune system in blood samples in response to early stage ovarian tumor cell development. In clinical research, the test has indicated high sensitivity and specificity for all types and stages of ovarian cancer.

Following FDA approval, Avant intends to offer OvaDx as an elective test for women in the elevated risk category for ovarian cancer, as well as those seeking greater wellness. As the market’s first large panel screening test for ovarian cancer, OvaDx is expected to greatly improve the early diagnosis rate of ovarian cancer and, as a result, advance the survivability of this deadly disease.

For more information, visit www.avantdiagnostics.com

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Avant Diagnostics, Inc. (AVDX) Leading the Next Advance in the ‘War on Cancer’ through the Development of OvaDx®

December 23, 2015

The American Cancer Society estimates that about 21,290 new cases of ovarian cancer will be diagnosed in 2015, and roughly 14,180 women will die from the illness within the United States. These figures outline the severity of ovarian cancer, which is currently the eighth most common cancer among women, as well as the fifth leading cause of cancer-related death among women, according to data from SEER. Over the past forty years, mortality rates for ovarian cancer have recorded a mild decline as a result of the ongoing ‘War on Cancer’, but these improvements pale in comparison to the progress made on some other forms of the disease. Today, nearly half of all cancer patients can expect to live for five or more years after diagnosis with proper treatment.

With this data in mind, the question regarding ovarian cancer becomes clear: Why hasn’t more progress been made toward improving survivability? To understand the answer to this question, one needs to take a closer look at the illness.

Ovarian cancer begins when healthy cells in an ovary mutate and begin to grow uncontrollably, forming a mass known as a tumor. Tumors come in two basic forms – cancerous and benign. While benign tumors can cause problems by continuing to grow, cancerous tumors are, by far, the more dangerous form. Cancerous tumors on the ovaries are malignant, meaning they can continue to grow and spread to other parts of the body. For this reason, catching the disease in its early stages is paramount to improving survivability rates.

When diagnosed early, ovarian cancer is actually an extremely survivable disease. According to data from the American Cancer Society, individuals with ovarian cancer that’s diagnosed in stage I boast a five-year survivability rate of approximately 90 percent. However, this outlook is significantly worse when the illness isn’t discovered until the later stages. In stage II, the five-year survivability rate for invasive epithelial ovarian cancer, which accounts for roughly 85 percent of all cancers of the ovaries, falls to 70 percent. In stage III, survivability is just 39 percent.

With the importance of early detection clearly illustrated, a massively underserved indication within the diagnostic market becomes evident. The National Ovarian Cancer Coalition reports that almost 70 percent of women diagnosed with the common epithelial ovarian cancer are not diagnosed until the disease is advanced in stage.

Current ovarian cancer detection methods are hampered by a variety of factors. The simplest check, a pelvic exam, consists of a health care professional feeling the ovaries and uterus for size, shape and consistency. While these tests are relatively effective for some reproductive system cancers, most early ovarian tumors are difficult or impossible for even the most skilled examiner to feel. Screening tests and exams are also used for detection in people who don’t display any symptoms. However, both transvaginal ultrasound (TVUS) and the CA-125 blood test have drawbacks.

In the case of TVUS, sound waves are used to study the reproductive system. These waves can help physicians locate tumors on the ovaries, but they doesn’t help determine if the mass is cancerous or benign. The CA-125 blood test, on the other hand, checks the patient’s blood for high levels of the CA-125 protein, which is commonly associated with ovarian cancer. The effectiveness of this test is also hindered, because many common conditions other than cancer can cause high levels of CA-125.

Avant Diagnostics, Inc. (OTCQB: AVDX) is developing a novel approach to ovarian cancer screening that has the potential to fill this underserved need in the medical community. OvaDX® is a sophisticated microarray-based test that measures the activation of the immune system in blood samples in response to early stage ovarian tumor cell development. In clinical research, OvaDX has displayed high sensitivity and specificity for all types and stages of ovarian cancer – including stage IA-IV borderline serous, clear cell, endometrioid, mixed epithelial, mucinous, serous and ovarian adenocarcinoma. Following FDA approval, Avant plans to market OvaDx to doctors as a supplement to existing tests for women seeking greater wellness, as well as those in the elevated risk category for ovarian cancer.

As of its latest update, Avant had received FDA approval for ovarian cancer specimens to be used in a forthcoming validation study to support a pre-submission package to the FDA. After this package is submitted and reviewed, the company will look to commence the OvaDx 510(k) trial, which it plans to conduct in a double-blinded environment supervised by an independent clinical research organization.

For more information, visit www.avantdiagnostics.com

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Avant Diagnostics, Inc. (AVDX) Noninvasive, Pre-Symptomatic Ovarian Cancer Diagnostic Platform Could Also Address Many Other Diseases

December 16, 2015

According to the latest data from the American Cancer Society, in the U.S. alone over 21,000 women will be diagnosed with ovarian cancer this year, and more than 14,000 will perish from the disease. In most cases, ovarian cancer is detected by a combination of symptomatic expression and/or the discovery of a mass or lump during a routine pelvic examination. The disease is generally feared as a silent killer due to routinely being detected in later stages, after the problem has already become unwieldy.

This is most unfortunate given that if ovarian cancer can be detected early enough, the primary endpoint of five-year survivability is actually quite good, coming in at around 92 percent or greater. The sad reality however, is that the vast majority of cases are not detected early and are instead only identified after the cancer has already spread far away from the ovary, forcing the five-year survivability endpoint down to as low as 27 percent, or even as low as 18 percent. To complicate matters, the only way to currently obtain a certain diagnosis is through exploratory surgery (either via less invasive laparoscopy or open surgery if malignancy is expected), and if an apparently cancerous growth is observed on an ovary, a biopsy is typically forgone in favor of removing the ovary outrightly. This is in part due to the risk of a biopsy spreading the otherwise potentially localized cancer, as well as because the removal of only one ovary will not necessarily induce menopause or infertility in the patient, so long as the other ovary is in good condition.

Luckily, minimally invasive early detection technologies are rapidly evolving. Many of which are focused on exploiting key cancer biomarkers in order to bypass the need for surgical examination. In fact, according to a publication from MarketsandMarkets out earlier this year in August, the global cancer biomarkers market has really taken off over the last handful of years, and it is currently on track to experience a CAGR of 11.6 percent through 2020. This segment of the global cancer diagnostics space, which is on track to reach upwards of $168 billion over the same interval (according to a report published late last year by Transparency Market Research), is currently dominated by major players like Abbott Laboratories (NYSE: ABT), Agilent (NYSE: A), Merck (NYSE: MRK) and Roche (OTC: RHHBY), but there is also considerable room for true innovators to breakout via disruptive technologies.

One company of particular interest here is Avant Diagnostics (OTC: AVDX). Avant has secured a worldwide licensing and sponsored research agreement with Sunnyvale, California-based life sciences developer Arrayit Corporation (OTC: ARYC) and Wayne State University in order to progress the state of the art in pre-symptomatic, noninvasive ovarian cancer screening. Leveraging the patented and proprietary microarray platform developed by Arrayit, AVDX is currently advancing its flagship diagnostic OvaDx®, a high sensitivity/specificity screening platform, which has been shown in extant research to be effective for all types, as well as stages of ovarian cancer. Currently proposed for monitoring women who have already been diagnosed with ovarian cancer, OvaDx could go from benchmarking aide to default frontline diagnostic very quickly, making the company an extremely attractive play for investors.

Recent reception of IRB approval from the FDA in order to validate OvaDx amid an ongoing run up to 510(k) approval has put the company in a kind of pole position, out ahead of the field with a nearly-ready diagnostic tool for physicians that could allow for everything from improved monitoring of diagnosed patients and the identification of optimal surgical approaches, to better chemotherapy targeting, and synergy with other existing tests. Effectively the market’s first large panel screening solution for ovarian cancer, OvaDx has the potential to be a real game changer in women’s health, and the raw versatility of the underlying technologies places numerous other diseases well within striking distance of the company’s rapidly-developing diagnostic pipeline, including diseases ranging from other cancers such as breast, prostate, pancreatic, and throat/neck, to CNS diseases like Alzheimer’s and Parkinson’s.

Highly accurate, rapid turnover-capable, noninvasive testing technology like this could transform the diagnostic market for certain diseases in short order, and AVDX is very bullish about the potential to build out a pipeline of as many as six key diagnostic tests over the next few years. By combining organic development of existing capabilities, as well as acquisition of parallel or complementary diagnostic technologies, Avant seeks to transcend the ovarian cancer screening market longer term, applying the power of microarray biomarker validation to a whole host of diseases.

For more information, visit www.avantdiagnostics.com

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Avant Diagnostics, Inc. (AVDX) Targets Corporate Transparency with Launch of New Website

December 15, 2015

Avant Diagnostics, Inc. (OTC: AVDX) is on a mission to maximize its levels of corporate transparency for the benefit of its customers and investors. Late last week, the company took a significant step toward realizing this goal when it unveiled its new website. The new site utilizes a number of design features aimed at making browsing both streamlined and informative for Avant’s current and potential customers and investors.

The site’s investor relations section, in particular, received a considerable upgrade, incorporating helpful features such as immediate posting of press releases and automated posting of SEC filings, XBRL data, Insider Section 16 filings and financial statements. Additionally, the company has incorporated CEO interviews and media coverage, corporate videos and an up-to-date frequently asked questions section in order to more adequately inform visitors about Avant’s latest advances.

“A significant part of Avant’s mission is presenting those interested in the company with the information they want in the quickest and most organized way,” Gregg Linn, president and chief executive officer of Avant, stated in a news release. “We believe our new website advances this goal by presenting our range of services and activities in an attractive and easy-to-access format.”

In the months to come, Avant in strategically positioned to continue the development of its pre-symptomatic ovarian cancer screening test, OvaDx®. Leveraging more than 10 years of research and development and a strong intellectual property portfolio, the company is seeking to reduce the costs associated with ovarian cancer detection while helping medical providers avoid costly late stage disease treatments.

According to data from the American Cancer Society, ovarian cancer ranks fifth in cancer deaths among women, accounting for more fatalities than any other cancer of the female reproduction system. However, early detection can play a major role in improving the survivability of this dangerous disease. According to the National Cancer Institute, ovarian cancer cases discovered in stage I development present patients with a five-year relative survival rate in excess of 92 percent. Despite the benefits of early detection, only about 15 percent of ovarian cancer cases are currently diagnosed at stage one.

Through the development of OvaDx, Avant is seeking to provide a more effective option for detecting early stage ovarian cancer. The microarray-based diagnostic test, which, upon FDA approval, is expected to be offered as an elective test for women with elevated risk of ovarian cancer, has been shown to detect stage IA disease markers with approximately 80 percent sensitivity and 100 percent specificity.

For more information, visit www.avantdiagnostics.com

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Avant Diagnostics, Inc. (AVDX) Aims to Provide Early Detection Solutions for Better Treatment Options

December 9, 2015

Avant Diagnostics, Inc. is a company that focuses on the commercialization of proprietary microarray-based tests for the early detection of cancers, neurodegenerative diseases, and more. The company’s leading product is OvaDx®, a non-invasive pre-screening test that detects ovarian cancer by measuring the activation of the immune system in blood samples in response to early stage ovarian tumor cell development. This is the market’s first large panel screening test designed to detect ovarian cancer early. With early detection, more treatment options become available for patients that should delay or prevent disease progression. OvaDx® would be an optional supplement to existing tests such as CA-125, OVA1, and transvaginal ultrasounds.

In October 2015, Avant Diagnostics received a notice that its previously purchased specimens had been approved to use in the upcoming validation study to support a pre-Submission package to the United States Food and Drug Administration (FDA). The company intends to start the FDA validation study shortly after completing calibration testing. Once that process is finalized, Avant Diagnostics will test the approved specimens as a basis for the submission package. The company hopes its innovative product can then begin its 510(k) trial.

In a news release, Gregg Linn, Avant’s chief executive officer and president, stated, “Avant continues to make steady progress towards its goal of obtaining FDA 510(k) clearance for OvaDx®. We intend to periodically communicate with our shareholders and markets as we progress through the FDA negotiations and through FDA’s review of our 510(k) submission.”

According to the American Cancer Society, 21,290 women are expected to be diagnosed with ovarian cancer in 2015 alone. Adding to that number are 14,180 deaths from the disease. Furthermore, 1 in 75 women are at risk for this disease, which is the fifth leading cause of female cancer deaths.

By developing effective pre-screening tests, like OvaDx®, Avant Diagnostics aims to greatly improve the quality of life among patients by giving them the opportunity for early treatment options.

For more information, visit www.avantdiagnostics.com

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Avant Diagnostics (AVDX) Out Front in Early Detection and Screening for Ovarian Cancer

December 2, 2015

Avant Diagnostics (OTC: AVDX) is a leading medical technology company focused on advancing innovative solutions that improve upon the ways we screen for ovarian cancer. AVDX’s energy and resources aim to bring to market innovative diagnostic tests based upon the completion of the human genome sequencing project. The company works at developing a sophisticated screening test for diagnosing ovarian cancer using OvaDx® – a unique large-panel biomarker screening test for this deadly disease.

OvaDx is an advanced diagnostic test used specifically for measuring the activation of the immune system in response to ovarian tumor cell development. Patient sera are used in conjunction with OvaDx microarrays, which enable binding between proteomic biomarkers in the patient samples and capture agents on the microarrays. In this process, the microarrays are washed and scanned to produce a digital readout for each serum sample. From this point, the data are quantified and analyzed using software to produce the results of the test.

AVDX’s discovery path comes by way of ten years of genetic and physiological research. Avant Diagnostics concentrates on leveraging the human immune system for early detection. As a result, OvaDx delivers a large panel of refined markers for high sensitivity. The company’s proprietary OvaDx markers and kits include patented manufacturing technology, as well as a worldwide license. Following FDA 510(k) clearance, the company plans to license OvaDx for sale. Avant’s business plan looks to use its position as a public company to expand its portfolio of diagnostic tests going forward.

Genetic research is predominantly centered on identifying the variations of the specific genes in the genome. These variations define individual characteristics, including disease states or a statistical propensity for disease. The implications are far-reaching and impact not only the research community, but also the individual patients and care providers. Diagnostic tests that detect diseases very early in their progression will provide options for earlier treatments that show promise of improving quality of life and prognosis by delaying or preventing disease progression. It has been noted that medical providers will realize major cost savings by avoiding costly treatments at late stages.

For more information, visit www.avantdiagnostics.com

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Avant Diagnostics (AVDX): An Ounce of Prevention is Worth a Pound of Cure

November 24, 2015

Early detection of cancer is the key to using the medicines available today to battle cancer and give the patient the best chance of beating this horrible disease and getting back to a normal life. Avant Diagnostics (AVDX) has undertaken this heroic challenge with its OvaDx Pre-Symptomatic Ovarian Cancer Screening Test.

OvaDx is a sophisticated microarray-based test that measures the activation of the immune system in blood samples in response to early stage ovarian tumor cell development.

Each year, cancer costs the world more money than any other disease, according to the American Institute of Cancer Research (AICR).

Cancer costs $895 billion annually. Comparatively, heart disease costs $753 billion. Nothing else comes close, with traffic accidents and diabetes each costing about $204 billion. More than half a million Americans die of cancer, the second-leading cause of death in the U.S., every year.

Cancer is like any disease, ailment, or problem in that the earlier you correctly identify and get to work on fixing it, the better your chances are… Let’s just use Peyton Manning as a good example of what to do. When he throws an interception, he immediately goes to the sideline, talks to coaches, studies stills of defensive alignments and identifies what he could have done better to throw a touchdown instead of the interception.

Using a product like OvaDx would be the best way to identify the exact nature of the problem, so experts and doctors can recommend the best treatments to ensure your survival. Cancer does not discriminate, as you can see from the above study, and takes very few prisoners, especially when you sit back and do nothing. Companies developing state of the art technology like AVDX give patients the best chance at beating this horrible disease and living a long and happy life.

In conclusion, put AVDX on your radar, especially considering recent FDA developments. It would be well worth your time to educate yourself a little more on early cancer detection and participate in the battle affecting everyone in the world today.

For more information, visit www.avantdiagnostics.com

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Avant Diagnostics, Inc. (AVDX) Employs Impressive Leadership to Obtain Goals in Disease Prevention

November 18, 2015

Avant Diagnostics, a medical technology company, continues its objective of mapping out the entire DNA sequence of a human genome. This development would benefit the entire human population as scientists would be able to treat, prevent, and cure disease. Genome is the genetic material of an organism that consists of DNA and therefore acts as a textbook of how the human body works. Scientists would be able to identify a person’s propensity of disease through testing which would promote early treatment and hopefully a cure.

Leading this innovative company as its president and CEO stands Gregg Lynn. After receiving his Master’s degree in Business Administration, summa cum laude, from Pace University-New York City in 1992, he held various Senior Financial Management positions at Fortune 500 companies and also acted as Senior Financial Analyst at Shearson Lehman. During 2001-2007, Lynn held the positions of Chief Executive Officer and Chief Financial Officer at various companies including Red Rock Advisors, LLC. In 2008, he became the president and managing member of Issuers Capital Advisors, LLC. Then in 2012, Lynn became the Chief Operating Officer and Chief Financial Officer of Avant Diagnostics which led to his current position. His successful resume speaks for itself of his qualifications and promising future with Avant Diagnostics.

For the science and technology aspect of the company there is the Scientific Advisory Board where Robert Bowser, PhD sits. The Neurology and Neurobiology professor studies the causes and potential treatments for ALS, Parkinson’s disease, Alzheimer’s disease, and more at the Barrow Neurological Institute. He’s received various federal grants and U.S. patents while lecturing extensively all over the world. Holding a graduate degree from Yale, Bowser boasts a 17-year faculty position at the University of Pittsburgh before starting at the institute. He’s also the founder of Knopp Biosciences, LLC and Iron Horse Diagnostics. Bowser’s expertise lends itself to the company’s scientific breakthroughs in medicine.

The notable leadership at Avant Diagnostics should enable the success of its scientific developments in disease prevention and treatment. Currently, the company’s OvaDx® Pre-Symptomatic Ovarian Cancer Screening Test is at the forefront of Ovarian Cancer detection. The company aims to have this product available for commercialization after FDA approval.

For more information, visit the company’s website at www.avantdiagnostics.com

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Avant Diagnostics (AVDX) Leading an Evolution in Early Detection of Ovarian Cancer

November 11, 2015

Avant Diagnostics is a medical technology company at the forefront of driving an evolution in the screening of ovarian cancer. Its focus is centered on bringing to market innovative diagnostic tests based upon the completion of the human genome sequencing project. The company endeavors in developing a refined screening test for diagnosing ovarian cancer by way of OvaDx – the market’s first large-panel biomarker screening test for this deadly disease.

OvaDx® is considered to be an advanced diagnostic test that measures the activation of the immune system in response to ovarian tumor cell development. Patient sera are applied to OvaDx® microarrays which enable binding between proteomic biomarkers in the patient samples and capture agents on the microarrays. The microarrays are washed and scanned to produce a digital readout for each serum sample, and the data are quantified and analyzed in software to generate the test results.

Medical findings in genetic research offer extensive opportunities for impacting both the diagnosis and treatment of critical diseases. It focusses on identifying variations in specific genes in the genome, variations which reveal individual characteristics, including the state of the disease or its statistical characteristics. Tests of this nature that detect diseases at early stages in their progression and thus offer different options for earlier treatments resulting in better outcomes for the patient. As an additional result, medical providers benefit by way of significant cost savings by avoiding costly treatments traditionally reserved for cancer in its later stages.

ADVX’s discovery path is a result of a decade of genetic and physiological research. The company concentrates on capitalizing on the human immune system for early detection. The result, OvaDx, delivers a large panel of refined markers for high sensitivity. The company’s OvaDx markers and kits are proprietary, include patented manufacturing technology, and an exclusive, worldwide license. Upon FDA 510(k) clearance, Avant intends to sell or license OvaDx®. Avant intends to utilize its public company stage to expand its portfolio of diagnostic tests in the future.

For more information on the company, visit www.avantdiagnostics.com

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Avant Diagnostics, Inc. (AVDX) Offers A New Approach To Diagnosing A Deadly Cancer

November 6, 2015

Avant Diagnostics, a medical technology company focused on bringing to market cutting-edge diagnostic tests based upon the completion of the human genome sequencing project, has developed a sophisticated and much-needed screening test for diagnosing ovarian cancer. OvaDx is the market’s first large-panel biomarker screening test for ovarian cancer.

Discoveries in genetic research offer far-reaching opportunities for impacting both the diagnosis and treatment of serious disease. It centers on identifying variations in specific genes in the genome, variations that define individual characteristics, including disease states or a statistical propensity for disease. Diagnostic tests that detect diseases early in their progression will provide options for earlier treatments to improve the quality of life and outcome by delaying or preventing disease progression or even death. Medical providers will enjoy major cost savings by avoiding costly late stage disease treatments.

The American Cancer Society estimated diagnosis in 2013 of about 22,240 new cases of ovarian cancer, with perhaps 15,500 ovarian cancer deaths in the U.S., making ovarian cancer the fifth leading cause of cancer death among U.S. women. Other cancers have shown a marked reduction in mortality due to the availability of early detection tests and improved treatment, but this has not been the case with ovarian cancer, which has been called “the silent killer”. Early stage disease symptoms are often ignored, and current tests can lead to false diagnosis and unnecessary treatment. One study found that, on average, for every one case of ovarian cancer detected, 33 women had surgery for a false positive.

The Avant Diagnostics approach is based upon 10 years of genetic and physiological research, focused on exploiting the human immune system for early detection. The result, OvaDx, offers a large panel of refined markers for high sensitivity. OvaDx markers and kits are proprietary, with a patented manufacturing technology, and a worldwide exclusive license, and the company is progressing toward FDA 510(k) clearance for OvaDx.

For more information on the company, visit www.avantdiagnostics.com

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Avant Diagnostics, Inc. (AVDX) Blazing Trail to Fulfill Need for Effective Ovarian Cancer Screening Technology

October 29, 2015

Each year, approximately 20,000 women in the United States get ovarian cancer, which causes more deaths than any other gynecologic cancer, according to the Centers for Disease Control. While the disease often causes signs and symptoms, the signs can be hard to recognize; and for the time being, the market is lacking an available, effective screening test for ovarian cancer. Thanks to one particular advancing technology, however, this could soon change.

Because ovarian cancer symptoms can be hard to recognize, effective screening is vital, and medical diagnostic technology company Avant Diagnostics stands at the edge of breakthrough. The company is currently testing OvaDx®, its sophisticated microarray-based test designed to detect pre-symptomatic ovarian cancer faster than ever before.

Research studies with OvaDx indicate high sensitivity and specificity for all types and stages of ovarian cancer. Upon FDA approval, Avant Diagnostics will offer OvaDx as an elective test for women seeking greater wellness and for women in the elevated risk category (which includes something as simple as getting older) for ovarian cancer.

OvaDx works by measuring the activation of the immune system in blood samples in response to early stage ovarian tumor cell development. The goal is for OvaDx to be used by doctors for early detection, improved surgical options, more effective chemotherapies, and to supplement existing tests such as CA-125, OVA1® and transvaginal ultrasound. In this way, Avant Diagnostics’ technology will promote earlier diagnoses and, as a result, improved survival rates for patients with ovarian cancer.

That said, it’s worth taking a look at Avant Diagnostics’ progress in bringing this game-changing product to market. The company continues to steadily progress toward FDA 510(k) clearance for OvaDx. DOCRO, Avant Diagnostics’ independent clinical research organization, recently received notification that the previously purchased specimens have been approved and are available for use in the upcoming validation study which will be used to support a pre-submission package to the FDA prior to the commencement of the OvaDx® 510(k) trial.

Continuing on its path toward FDA approval of its groundbreaking diagnostic technology, Avant Diagnostics is poised to promote considerable growth in the ovarian cancer market and deliver a promising solution to a significant unmet medical need.

For more information, visit www.avantdiagnostics.com

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Avant Diagnostics, Inc. (AVDX) Preparing to Commence Pivotal Validation Study for OvaDx®

October 21, 2015

October is international breast cancer awareness month, but it’s also a great time to take a look at the effects that other types of cancer have on the global population. Each year, over 20,000 women in the United States are diagnosed with ovarian cancer, and more than 14,000 women die from the devastating disease. According to the Centers for Disease Control and Prevention, despite accounting for just three percent of all cancers in women, ovarian cancer causes more deaths than any other cancer of the female reproductive system.

The key to surviving ovarian cancer, according to the National Cancer Institute, is early detection. When discovered in a localized stage, current treatment options enable a five-year survivability rate in excess of 92 percent. However, when ovarian cancer remains undiagnosed until the distant stages, which feature cancer on one or both ovaries as well as distant metastases on the liver or lungs, five-year survivability falls to less than 22 percent.

Avant Diagnostics, through the development of OvaDx®, is preparing to make diagnosis of early-stage, pre-symptomatic ovarian cancer faster than ever before. OvaDx is a sophisticated microarray-based test that measures the activation of the immune system in blood samples in response to early-stage ovarian tumor cell development. In clinical trials, Avant’s proprietary diagnostic technology has indicated high sensitivity and specificity for all types and stages of ovarian cancer – including stage IA-IV borderline serous, clear cell, endometrioid, mixed epithelial, mucinous, serous and ovarian adenocarcinoma.

Earlier this month, the company took a significant step toward achieving regulatory approval for OvaDx when it announced that it had secured ovarian cancer validation test specimens for use in its forthcoming validation study. The results of this study will be used to support Avant’s pre-submission package to the United States Food and Drug Administration, which will be submitted prior to the commencement of the company’s pivotal OvaDx 510(k) trial.

“Avant continues to make steady progress toward its goal of obtaining FDA 510(k) clearance for OvaDx,” Gregg Linn, president and chief executive officer of Avant, stated in a news release. “We intend to periodically communicate with our shareholders and markets as we progress through the FDA negotiations and through FDA’s review of our 510(k) submission.”

When approved, Avant intends to market OvaDx as both an aid in monitoring women previously diagnosed with ovarian cancer and an elective screen for women seeking greater wellness. Through these efforts, the company has an opportunity to greatly improve the survivability of this deadly disease while simultaneously promoting sustainable financial growth in the competitive biopharmaceutical industry.

For more information, visit www.avantdiagnostics.com

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Avant Diagnostics, Inc. (AVDX) Leads Development in Early Ovarian Cancer Detection Technology

October 15, 2015

Great strides in medical technology are being undertaken by Avant Diagnostics, a company that focuses its developments on the human genome project, which aims to map out the entire DNA sequence of a human. Innovations in this endeavor may treat, prevent, and cure disease as scientists will have a blueprint of how humans have developed over time along with what genes lead to illness. The company hopes to develop genetic research that can detect illness early in individuals so that treatment can avert progression or death.

With this goal in mind, Avant Diagnostics has developed the first large panel biomarker screening test for ovarian cancer. This test, OvaDx®, measures the activation of immune systems in blood samples in response to early stage ovarian tumor cell development. The test has high sensitivity to readings at 79.7% and can identify stage I, II, III, and IV Ovarian cancer with great accuracy. With ~80% sensitivity, IA disease can also be detected.

According to the American Cancer Society, 21,290 women will be diagnosed and 14,180 will die from ovarian cancer this year. A woman’s risk of getting the cancer is 1 in 75, making early detection technology essential. Currently, the three leading detection processes are the pelvic exam, transvaginal ultrasound, and CA-125 blood test. However, each of these tests lack accuracy and do not necessarily lower the cancer’s death rate.

The company is currently underway in testing previously acquired ovarian cancer specimens that will serve as a validation study for the pre-Submission package to be submitted to the Food and Drug Administration (FDA) for review. Then a trial for OvaDx® 510(k) can begin. The company needs to get the FDA’s approval for the product before selling. This microarray-based test will be offered to women for overall health checkups and to those who have a predisposed risk to the cancer.

Avant Diagnostics intends to develop advanced early detection technologies that will then lead to developments in surgical options and therapies for patients. Furthermore, if OvaDx® gains FDA approval, women will have another, more accurate, option for ovarian cancer detection.

For more information, please visit www.avantdiagnostics.com

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Avant Diagnostics Inc. (AVDX) Announces FDA IRB Approval for OvaDx(R) Ovarian Cancer Validation Test Specimens

October 7, 2015

Avant Diagnostics, an innovative in vitro diagnostics company, today told investors that the previously purchased specimens have been approved and are available for use in the upcoming validation study to be used to support a pre-Submission package to the United States Food and Drug Administration (“FDA”).

Avant anticipates that the FDA validation study will start shortly after the ongoing calibration testing is completed. Upon completion, Avant intends to test the previously purchased set of ovarian cancer specimens, including serial sets obtained from women diagnosed previously with ovarian cancer, which will serve as the validation study and form the basis of the pre-Submission package that will be submitted to FDA for review and comment prior to the commencement of the OvaDx® 510(k) trial.

The OvaDx® microarray test is designed to be used as an aid in monitoring women diagnosed previously with ovarian cancer. The validation study and 510(k) trial will be conducted in a double-blinded environment supervised by DOCRO, Inc., an independent clinical research organization. The results from the validation study are expected to be published in a peer-reviewed scientific journal within six months of test completion and data analysis; however there can be no assurance that such publication will be completed within this time frame.

Gregg Linn, Avant’s Chief Executive Officer and President, stated, “Avant continues to make steady progress towards its goal of obtaining FDA 510(k) clearance for OvaDx®. We intend to periodically communicate with our shareholders and markets as we progress through the FDA negotiations and through FDA’s review of our 510(k) submission.”

For more information, visit www.avantdiagnostics.com

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