Category Archives: Boston Therapeutics Inc. BTHE

Boston Therapeutics, Inc. (BTHE) Addressing the Diabetes Epidemic with Promising Drug Candidates

January 27, 2014

Approximately 25.8 million Americans have diabetes, according to the National Diabetes Education Program, making the disease the seventh leading cause of death in the United States. To put it in monetary perspective, diabetes runs up an annual tab of $174 billion in total healthcare and related treatment costs.

Boston Therapeutics is focused on the development and commercialization of novel compounds based on complex carbohydrate chemistry to address unmet medical needs, including diabetes. The company’s current product pipeline is comprised of therapies developed to treat patient populations with Type 2 diabetes, which accounts for 90-95 percent of all diagnosed cases of diabetes in adults.

PAZ320 is Boston Therapeutics’ chewable drug candidate designed to prevent diabetes and its complications. The company believes PAZ320 is a safe and effective drug compound for people with pre-diabetes and diabetes in their daily management of blood glucose levels, fulfilling an unmet medical need of increasing proportion. In its phase 2 clinical trial, 45 percent of the patients saw a 40 percent reduction in the elevation of post meal blood sugar compared to baseline.

IPOXYN, a universal oxygen carrier, is Boston Therapeutics’ injectable drug candidate for the prevention of necrosis (premature cell death following ischemia) and ischemic conditions, which are caused by the shortage of oxygen supply to the tissue due to restriction in blood supply. Necrosis is the outcome of severe and acute injury, involved in many pathological conditions, including diabetes. For now, the only treatment for necrosis is providing oxygen by a high pressure facility, creating a crucial need to develop drugs for prevention and treatment of this pathology.

Supported by a highly dedicated management and advisory team with extensive expertise in complex carbohydrate chemistry, regulatory affairs, and clinical development, Boston Therapeutics is well-positioned to advance position as a high-potential developer of complex carbohydrate-based new chemical entities for the treatment of diabetes.

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Boston Therapeutics, Inc. (BTHE) Prepares for Third Phase Trial of PAZ320

January 21, 2014

Boston Therapeutics is a pharmaceutical company focused on the development, manufacturing, and commercialization of novel compounds based on complex carbohydrate chemistry to address unmet medical needs in diabetes.

PAZ320 is an integral part of the company’s initial product pipeline, which is focused on developing and commercializing therapeutic molecules. PAZ320 is a non-systemic, non-toxic, chewable drug which inhibits the enzymes that release glucose from complex carbohydrates in foods during digestion, reducing the amount of available glucose absorbed through the intestine.

In November, Boston Therapeutics enrolled 24 patients with Type 2 diabetes in a Phase IIb clinical study on PAZ320, and positive results from the trial were published by the principal investigator in the July/August issue of the journal “Endocrine Practice”. After evaluating the safety and efficacy of PAZ320, it was shown that there was a significant 40% reduction in elevation of post-meal blood glucose in the participating patients, with no serious adverse events.

By the second or third quarter of 2014, the company hopes to begin an important Phase III trial of the chewable tablet it is promoting as a potential adjunct to metformin in patients living with Type 2 diabetes. While the Phase IIb trial was held only in France, the Phase III trial will be multi-national–in the United States, Europe, Hong Kong, and China.

The company believes that PAZ320 is a safe and effective drug compound for people with pre-diabetes and diabetes in their daily management of blood glucose levels, fulfilling an unmet medical need. The intent is for this compound to provide individuals with a means by which to slow the onset of Type 2 diabetes and/or the onset of diabetes complications such as heart disease, stroke, kidney damage, retinopathy, and Diabetic Foot.

PAZ320 is meant to be taken before meals and works in the gastrointestinal tract to block the action of carbohydrate-hydrolyzing enzymes that break down complex carbohydrates into simple sugars, reducing the availability of glucose for absorption into the bloodstream.

For more information about PAZ320 or any of the company’s other products, visit the website at www.bostonti.com

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Boston Therapeutics, Inc. (BTHE) Heads into 2014 with Strong, Experienced Leadership

January 13, 2014

Boston Therapeutics is developing a pipeline of novel compounds to address unmet medical needs in diabetes. The company’s current product pipeline is focused on developing and commercializing the therapeutic molecules PAZ320 for patients with diabetes; and IPOXYNT for a wide rand of indications such as anemia and blood loss (injury), cardiovascular disease, and surgical blood supplementation.

Boston Therapeutics’ technology platform in applied carbohydrate chemistry has been pioneered by company CEO Dr. David Platt, who for the last 20 years has worked alongside scientific collaborators to safely address medical needs for oral and injectable applications.

Dr. Platt is recognized worldwide as an expert in carbohydrate chemistry and has led two drug candidates from concept to human clinical trials. He also founded three publicly traded companies: Pro-Pharmaceuticals, Inc., SafeScience, Inc., and International Gene Group. Dr. Platt’s guidance is supported by an executive management team with more than 100 years of combined experience.

Providing additional expertise, Boston Therapeutics has established a scientific advisory team with extensive expertise in complex carbohydrate chemistry, regulatory, and clinical development, with multiple submissions and approvals to U.S. Food and Drug Administration.

Under this leadership, Boston Therapeutics anticipates initiating a pivotal phase 3 study of PAZ320. The two-year study, to be conducted in the U.S., Europe, Hong Kong, Korea, and China, will be evaluate the effects of the drug candidate on glucose and hemoglobin A1c (HbA1c) in approximately 300 Type 2 patients currently taking metformin.

In an earlier phase 2 study, PAZ320 achieved a 40 percent reduction in post-meal blood glucose levels with no serious adverse events.

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Boston Therapeutics, Inc. (BTHE) Tackles One of America’s Greatest Epidemics

January 6, 2014

It’s turning out to be one of the biggest epidemic waves in American history, with estimated costs nationally jumping approximately 40% in just the past 5 years, to roughly $1/4 trillion annually. The epidemic is diabetes, and the size and scope of the problem, including the disastrous drain on the country’s economy, is just now beginning to be fully appreciated. Less obvious and dramatic than high-profile diseases such as cancer, the hidden power behind the diabetes epidemic is that it affects so many people. It is now estimated that over 25 million Americans have the disease, though many are not aware of it, with nearly 80 million Americans in a state of prediabetes. Diabetes complications include heart disease, stroke, kidney damage, and retinopathy.

Driven, it is believed, by a generation of negative dietary and life style habits, diabetes is now becoming one of America’s primary healthcare targets. Unfortunately, such habits, and the industries that support them, are slow to change, and today there is a desperate need for medical technologies that can help stem the epidemic tide more quickly.

Boston Therapeutics believes it has developed the most effective single solution with PAZ320, the company’s non-systemic, non-toxic, chewable drug candidate for prevention of diabetes and its complications. The drug is currently undergoing clinical trials after getting promising results in initial studies. PAZ320 would be a miracle to millions of diabetic and prediabetic patients, or anyone seeking to better manage blood glucose levels, by inhibiting the enzymes that release glucose from complex carbohydrates in foods during digestion. As a result, the drug now has a near-term opportunity in what is already a $35 billion diabetes drug market.

PAZ320 is not Boston Therapeutic’s only product. They are also in pre-clinical stage development of IPOXYN, an injectable universal oxygen carrier for the prevention of necrosis and treatment of ischemic conditions which may lead to necrosis, and OxyFex, a veterinary facsimile to Ipoxyn.

For additional information, visit www.BostonTI.com

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Pivotal Phase 3 Trial a Key Objective for Boston Therapeutics (BTHE) in 2014

December 27, 2013

Boston Therapeutics is a pharmaceutical company using complex carbohydrate chemistry to advance its PAZ320 and IPOXYN drug candidates for the treatment of Type 2 diabetes. With 2013 under wraps, BTHE looks to have an exciting first half of the upcoming year.

In mid-2014, BTHE hopes to start a pivotal phase 3 study of PAZ320, a chewable tablet to be taken before meals to reduce post-meal elevation of blood glucose in Type 2 diabetics by blocking the action of carbohydrate-hydrolyzing enzymes.

The two-year study, to be conducted in the U.S., Europe, Hong Kong, Korea, and China, will evaluate the effects of PAZ320 on glucose and hemoglobin A1c (HbA1c) in approximately 300 Type 2 patients currently taking metformin.

Thus far, Acarbose is the only drug that has been developed for the non-systemic environment to prevent glucose formation, though it is accompanied by side effects and limited functionality. BTHE’s goal is to develop a superior drug without the side effects.

An earlier phase 2 study of PAZ320 suggests that the company is on the right track in doing so. In the study, 21 patients treated with PAZ320 achieved a 40 percent reduction in post-meal blood glucose levels with no serious adverse events.

BTHE in November began enrolling patients in a phase 2b clinical study of PAZ320. A total of 24 patients currently being treated with metformin will receive PAZ320 in a double-blind, placebo-controlled study. The primary endpoint of the study is to evaluate the effect of PAZ320 compared to placebo to determine post-meal blood glucose levels after consumption of a test meal. The company plans to announce safety and glucose results during the first quarter of 2014.

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Boston Therapeutics, Inc. (BTHE) is Creating a Better Drug to Prevent and Treat Diabetes

December 17, 2013

In the United States alone, an estimated 26 million people have Type 2 diabetes while another 80 million or so people are pre-diabetic. Recognizing that there are urgent, unfulfilled medical needs for both the pre-diabetic and diabetic community, Boston Therapeutics is concentrating on creating better technology to prevent diabetes and its complications.

Considering the varied and dangerous complications that stem from uncontrolled diabetes (such as heart disease, stroke, and kidney damage), Boston Therapeutics’ goal is to better control glucose levels in patients throughout the day using innovations in complex carbohydrate chemistry.

The key diabetic solution in the company’s arsenal is PAZ320, a non-systemic, non-toxic chewable drug candidate that is intended to be taken before meals to reduce the post-meal elevation of blood glucose in patients living with Type 2 diabetes. PAZ320 slows down the enzymes that release glucose from complex carbohydrates in foods during digestion and thereby reduces the amount of glucose absorbed through the intestine.

Boston Therapeutics is developing the PAZ320 drug for potential use with metformin, a popular anti-diabetic drug, and as a better alternative to Acarbose, which has side effects and limited functionality. PAZ320 has already completed a Phase 2 clinical trial to reduce post-meal glucose elevation and the company hopes to take it to Phase 3 trial by the third quarter of 2014.

Alongside PAZ320, Boston Therapeutics has two other products in the pipeline: IPOXYN and OXYFEX.

IPOXYN, a universal oxygen carrier and cell bodyguard, is an injectable drug candidate for the prevention of necrosis, the death of cells in an organ or tissue due to a failure of blood supply. IPOXYN would also be appropriate for the treatment of hypoxia, a deficiency in the amount of oxygen reaching the tissues, as well as other ischemic conditions which may lead to necrosis. IPOXYN oxygen carriers are in the pre-clinical stage of drug development.

OXYFEX, a reproduction of IPOXYN, is Boston Therapeutics’ offering to the veterinary market. OXYFEX is able to serve as an oxygen delivery mechanism for animals suffering from damaged or ischemic tissue due to traumatic and surgical blood loss.

Boston Therapeutics has engaged in designing, producing, and marketing novel compounds and therapeutic drugs that address diabetes and other inflammatory diseases since its start in 2009.

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Boston Therapeutics, Inc. (BTHE) Announces Three Management Appointments

December 10, 2013

Boston Therapeutics, an innovator of drugs that target diabetes using complex carbohydrate chemistry, today announced the appointment of three management positions within its ranks. Effective immediately, Edward Shea will serve as Vice President Business Development, Tina M. Gagnon will serve as Consulting Director of Finance, and Yael T. Bobruff, Ph.D. will serve as Clinical Affairs Manager, respectively.

David Platt, Ph.D., Chief Executive Officer, Boston Therapeutics, said, “As Boston Therapeutics enters the next phase of its growth, it is imperative that we attract top talent to help us advance and commercialize our drug development programs. Ed Shea and Tina Gagnon’s business and finance backgrounds, and Dr. Bobruff’s expertise in biology and research significantly strengthen our management team. I am pleased they have decided to join our company, and I look forward to working with them in the months and years ahead.”

Mr. Shea boasts of 25 years of experience in commercial development, marketing, and sales. Of that, 15 years of his experience includes business development, marketing, and sales leadership positions with GlaxoSmithKline and Salix Pharmaceuticals, as well as business development capacities with two startup biopharmaceutical companies, ViroPharma and Critical Therapeutics. Mr. Shea most recently worked with ViroPharma, Inc. as Sr. Eastern Area Sales Director. He holds a B.S. in Business/Marketing and an M.B.A. from Salve Regina University in Newport, RI.

Ms. Gagnon brings over 20 years of experience in finance. Most recently, she worked as Corporate Controller at Micronetics, Inc., at which she oversaw a staff responsible for accounts receivable, accounts payable, inventory management, and other activities. Beforehand, she served in the following capacities: Controller at Amherst Technologies, LLC; Assistant Controller of Fruit of the Loom’s Sports & Licensing Division; and Senior Corporate Auditor at Standex International Corp. Ms. Gagnon holds a B.S. in Accountancy from Bentley College.

Most recently, Dr. Bobruff was a postdoctoral researcher in the Department of Systems Biology at Harvard University Medical School in Boston. There, she investigated in depth the genetic processes and mechanisms contributing to the evolution of host-pathogen interactions. Dr. Bobruff holds a B.Sc. in Biology from the Hebrew University of Jerusalem, a M.Sc. in Civil and Environmental Engineering, and a Ph.D. in Biological Science from Stanford University.

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Boston Therapeutics, Inc. (BTHE) Takes Firm Stance Against Type 2 Diabetes, Backed by High-Potential Candidate Pipeline

December 9, 2013

Boston Therapeutics is developing a pipeline of therapeutic molecules based on complex carbohydrate chemistry. This pipeline currently carries three compounds that are being fine-tuned and tested in hopes that each will become a commercialized therapeutic treatment for diabetes.

Drug candidate PAZ320 is being developed for the prevention of diabetes and related complications. PAZ320 is a non-systemic, non-toxic, chewable drug candidate that inhibits the enzymes that release glucose from complex carbohydrates in foods during digestion. By blocking this release, the drug reduces the amount of available glucose absorbed through the intestine.

The company recently began enrollment for phase IIb trial in France to assess the efficacy and safety of PAZ320 in combination with metformin in patients with Type 2 diabetes. The company has also began preparation for an application of an investigational new drug (IND) submission to the U.S. FDA for phase III trial in the U.S., Europe, Hong Kong, and China to evaluate the effects of PAZ320 on post-meal glucose levels in patients with Type 2 diabetes.

In pre-clinical development is IPOXYN™, the company’s injectable therapeutic agent that utilizes proprietary processes and patented technology to prevent necrosis, the death of tissue from inadequate blood flow, and treatment of ischemic conditions that may result in necrosis. Necrosis is the outcome of severe and acute injury such as from pathological conditions such as heart attack, brain injuries and stroke, as well as neurodegenerative diseases such as Alzheimer’s disease, pancreatitis and many others. IPOXYN is targeting both human and animal tissues and organ systems deprived of oxygen and in need of metabolic support.

Aside from a gap in diabetes treatments in humans, Boston Therapeutics also recognizes the unmet need in the veterinary market for blood replacement and oxygen delivery due to damage or ischemic tissue as a result of trauma, surgery anemia or other disease conditions. For this application the company is developing OXYFEX™, which can serve as the only available oxygen delivery mechanism for animals suffering ischemia or traumatic and surgical blood loss events. OXYFEX is also in pre-clinical development.

Boston Therapeutics continues to advance its compounds to address the estimated 22 million people in the United States currently suffer from, and are enrolled in treatment for, Type 2 diabetes.

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Boston Therapeutics, Inc. (BTHE) Receives Positive Highlight at Seeking Alpha

In an article published recently on Seeking Alpha, Boston Therapeutics was highlighted as a biopharmaceutical company with promising investor potential. The article pointed to factors such as the company’s potentially “blockbuster” treatment for diabetes and its experienced management as reasons for its growing attractiveness among biomedical stocks.

The article also made note of Boston Therapeutics’ founder, chairman, and CEO, Dr. David Platt, and his focused mission on reversing the onset of diabetes globally. Dr. Platt’s determination to slow, if not reverse, the onset of diabetes seems well-grounded. According to the World Health Organization, in just 2000 177 million people worldwide had diabetes. The organization projects that number will increase to 300 million people by 2025, and estimates there are 4 million deaths a year across the globe due to the disease. In just the United States alone, the American Diabetes Association estimates that over 25 million children and adults have diabetes, of which 27% remains undiagnosed. Reverting back to the global focus, the effects and economic impact of diabetes are noted to be tremendous as well. The debilitating and chronic effects of diabetes, its rapid onset in the global population, and its costly implications have led the World Health Organization to classify the disease as a global epidemic.

Seeking Alpha highlighted that Dr. Platt is a world-renowned carbohydrate chemistry expert who was educated at the prestigious Hebrew University of Jerusalem. Prior to founding Boston Therapeutics, he founded and directed three other companies, Pro-Pharmaceuticals, Inc. (today known as Galectin Therapeutics), SafeScience, Inc., and the International Gene Group, in which he helped generate almost $1 billion in investor returns. He has since turned to harnessing the therapeutic power of complex carbohydrate chemistry to combat diabetes at Boston Therapeutics.

In regard to Boston Therapeutics’ treatment for diabetes, PAZ320, Dr. Platt spoke of the drug’s medical potential in an interview with InformationAboutDiabetics.com earlier this year. Noting that PAZ320 would have a positive breakthrough for pre-diabetics and all diabetics alike, he mentioned the well-established link between high blood sugar and diabetes and how the drug moves to lower blood sugar by blocking enzymes that digest sugars in the intestine during digestion. He noted that in a Phase II clinical study, PAZ320 was found to lower the elevation of blood glucose by 40% post-meal.

Speaking of the drug’s medical impact, Dr. Platt, in the same interview, opined, “The drug may reverse diabetes,” indicating perhaps something of its viability as a biomedical solution. Backed by the “bring-to-market” efforts of Boston Therapeutics’ executive management team, which has over 100 years of combined experience of c-level executive leadership, corporate finance and company operations finessing, bio-medical product innovation, and corporate consulting, the drug may indeed have the makings of being one of the next-generation scientific and medical innovations.

The full article at Seeking Alpha can be found at: http://seekingalpha.com/article/1864971-boston-therapeutics-a-speculative-biopharmaceutical-company-with-promise

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Boston Therapeutics, Inc. (BTHE) on Accelerated Path for Drug Development

November 25, 2013

Boston Therapeutics is a pharmaceutical company focused on the development and commercialization of novel compounds based on complex carbohydrate chemistry to address unmet medical needs. The company’s current product pipeline is focused on developing and commercializing the therapeutic molecules PAZ320 for patients with diabetes; and Ipoxyn™ for a wide rand of indications such as anemia and blood loss (injury), cardiovascular disease, and surgical blood supplementation.

The company’s lead product, PAZ320, is a non-systemic, non-toxic, chewable drug candidate that inhibits the enzymes that release glucose from complex carbohydrate in foods during digestion. Boston Therapeutics has developed the PAZ320 drug compound for people with pre-diabetes and diabetes in their daily management of blood glucose levels.

Ipoxyn™ is an injectable prescription drug developed to prevent necrosis and treatment of ischemic conditions which may lead to necrosis, a form of cell injury resulting in the death of cells in living tissue, such as with gangrene. The gloco-protein-based therapeutic agent is applicable to both human and animal tissues and organ systems deprived of oxygen and in need of metabolic support.

OxyFex™ is the company’s veterinary facsimile to Ipoxyn™, designed for the veterinary market as blood replacement and oxygen delivery to damaged or ischemic tissue due to trauma, surgery anemia, and other disease conditions.

Boston Therapeutics’ strategy is to develop PAZ320 and Ipoxyn™ by using the U.S. Food and Drug Administration’s Prescription Drug User Fee Act (PDUFA), which provides an expedited means of drug development.

Moving forward, the company continues to build on its momentum from positive results for PAZ320’s phase 2a safety and efficacy trial, and recently raised $5.3 million to fund ongoing clinical trials for PAZ320. Boston Therapeutics in early November began enrolling patients in a phase IIb clinical study on PAZ320.

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Boston Therapeutics, Inc. (BTHE) Presenting at Elsevier Therapeutic Area Partnerships 2013 Conference

November 18, 2013

Boston Therapeutics, a company focusing on the development of diabetes treatments using complex carbohydrate chemistry, continues to make progress in raising public awareness of its diabetes drug’s potential. The company announced in a news release today it will be presenting at the Elsevier Therapeutic Area Partnerships 2013 Conference, where it was selected as one of 10 “Top Projects to Watch” within the category of cardiovascular/metabolic diseases. Mr. Kenneth A. Tassey, Jr., President of Boston Therapeutics, will be presenting information about the diabetes drug PAZ320 at the conference.

From 2:15 to 3:05 PM on Tuesday, November 19, 2013, at the Hyatt Regency in Boston, Mr. Tassey will discuss how PAZ320 was recently found to exhibit Type 2 diabetes management efficacy in 45% of patients in an FDA Phase 2a clinical trial. PAZ320 is a non-systemic chewable tablet that lets patients manage their post-meal blood sugar levels, by targeting enzymes that digest sugar during digestion.

Mr. Tassey said, “TAP 2013 promises to be one of the key meetings of the year within the cardiovascular/metabolic disease area. We are pleased with this opportunity to educate attendees about the potential benefits of PAZ320, and are honored to be named a ‘Top Project to Watch’ by the independent panel.”

Since it was first started almost a decade ago, the conference has come to be one of the premier events in biopharmaceutical partnering. The event gathers the leading industry entrepreneurs and thought leaders to hear of the latest developments in biopharmaceuticals as well as provide quality networking opportunities. The “Top Projects to Watch” picks are determined by a panel of independent experts who screen hundreds of compounds and select the ones with the most potential as future products. Their criteria include: large market, large unmet need, with increasing opportunity; history of the molecule and drug; strong science; strong company; diversity of indications; potential for new opportunities beyond the initial indications; and multilevel partnering opportunities.

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Boston Therapeutics, Inc. (BTHE) Exhibiting PAZ320 at Inaugural Obesity Week 2013 Conference

November 14, 2013

Boston Therapeutics, a company focusing on the development of drugs using complex carbohydrate chemistry to address diabetes, reported in a news release today it is an exhibitor at the inaugural Obesity Week 2013 Conference in Atlanta, Georgia. The conference, taking place November 13-15, is billed as the world’s largest event on preventing and treating obesity, gathering the world’s leading scientists, clinicians, and surgeons for collaboration, data presentation, and networking.

At the conference, Boston Therapeutics will be in Booth #127, presenting information about its PAZ320, a non-systemic chewable tablet drug which targets enzymes that digest sugar during digestion. The drug therefore reduces the amount of glucose available for absorption by the intestine. Recently PAZ320 was found to help patients with type 2 diabetes manage their post-meal blood sugar levels in a successful FDA Phase 2a clinical trial.

Edward Shea, Vice President of Business Development, Boston Therapeutics, Inc., commented, “Our participation in Obesity Week 2013 — the world’s largest event on obesity treatment and prevention — will further demonstrate Boston Therapeutics’ commitment to those patients suffering from obesity and one of its devastating complications: diabetes.”

According to the American Diabetes Association, over 25 million children and adults in the U.S. have diabetes. Over 25% of that population remains undiagnosed, and 79 million are estimated to be pre-diabetic. In one study-illustration of diabetes’ economic impact, researchers found that people with diagnosed diabetes spend 2.3 times more on medical expenses than people without the condition, after adjusting for population and sex differences.

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Boston Therapeutics, Inc. (BTHE) Begins Enrolling Patients in Phase 2b Trial for PAZ320

November 12, 2013

Boston Therapeutics announced it has begun enrolling patients in a Phase 2b Trial for its PAZ320 drug today. A total of 24 patients with type 2 diabetes currently being treated with metformin will be administered PAZ320 under double-blind, placebo-controlled conditions. The study is taking place at Centre Hospitalier Robert Bisson, Lisieux, France.

Study performers will monitor the patients’ blood glucose using continuous glucose monitors, and their after-meal blood glucose levels measured using following a test meal. The primary endgoal of the trial is to evaluate the effect of PAZ320 compared to placebo the area under the curve (AUC) of glucose and on insulin levels in the blood for four hours following intake of the meal. Metformin is the most widely prescribed drug for diabetes, as well as the first drug often prescribed to new patients diagnosed with diabetes.

David Platt, Ph.D., Chief Executive Officer, BTHE, said, “This trial is designed to build upon the positive results from our Dartmouth Medical Center Phase 2a trial for PAZ320, recently published in the peer-reviewed journal, Endocrine Practice. In the Phase 2a study, PAZ320 was well tolerated in patients taking various anti-diabetic agents, including metformin. The Phase 2b trial, which focuses on patients taking only metformin, is the next step in the investigation of this compound as a potential adjunct to metformin in patients living with Type 2 diabetes. We believe it is important to better control glucose levels throughout the day, given the many complications that stem from uncontrolled diabetes.”

PAZ320 is a non-systemic, non-toxic, chewable drug for prevention of diabetes and its complications. It targets enzymes that digest sugar during digestion, thereby reducing the amount of available glucose for the intestine to absorb. According to the American Diabetes Association, 25.8 million children and adults in the United States have diabetes, of which 27% of that population remains undiagnosed.

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Boston Therapeutics, Inc. (BTHE) – Could the Move Away from Fats be Contributing to Obesity?

November 5, 2013

Although the idea of low-fat diets has a long history, it really took off in the 1980s when major American medical studies came down hard on cholesterol and animal fats, causing a revolution in the marketing of food. Suddenly meat and eggs and butter and cheese were thrown under a huge cloud of suspicion in the mind of consumers as possible contributors to heart attacks and stroke, and an unprecedented shift in eating habits started to take shape across the country. It was a painful move for many, but the medical and media pressure continued, and millions began to look for non-animal food products to satisfy their appetites.

It’s not surprising that, instead of turning to green beans and spinach, people began devouring carbs, and often carbs of the highly processed kind. People could happily munch on potatoes, rice, bananas, or other high glycemic index foods, without feeling concerns about health. You could have all the bread you wanted, just don’t put any butter on it. The most highly refined carbohydrate of all, sugar, was not a big part of meats, but could easily be integrated with cereals, breads, and, of course, deserts, so everything tasted sweet and good.

In the 1990s, the risks of a high-carb diet finally began to find their way back into the public’s attention, most prominently with the publication of books by cardiologist Robert Atkins, who based much of his thinking on the previous works of Dr. Alfred Pennington. Pennington had become convinced that weight loss was inversely related to the amount of glycogenic foods a person ate, and urged a diet higher in fat and lower in carbs.

Today, although there is still much controversy about the role of fats and cholesterol in the diet, there is increasing support for a move away from highly processed carbohydrates. Part of this conviction is the fact that such processed foods are foreign to human evolutionary development. People have long eaten meat, have long eaten vegetables and raw fruits, and have long eaten legumes. Later they learned to produce and consume whole grains. But the highly processed carb based foods that have become such a big part of the modern diet are essentially new.

Another major contributor to the move away from carbs is the catastrophic increase in obesity and diabetes, especially in the U.S., that has taken place in the last few decades. It’s clear now that highly processed carbohydrates, coupled with a sedentary lifestyle, can produce deadly results. The number of people with diabetes has skyrocketed in the past 10 years, and is expected to climb to over ½ billion by 2030. These are numbers that are having a major effect on biotech company Boston Therapeutics.

Boston Therapeutics is being catapulted to prominence by the results seen with the company’s lead drug candidate, PAZ320, the first diabetes drug to be based upon an important new technology, carbohydrate hydrolyzing enzyme inhibiting (CHEI). Unlike traditional diabetes drugs, PAZ320 doesn’t require insulin injections, and doesn’t involve interaction with important internal organs, such as the pancreas, kidneys, or liver. Instead, it is a simple chewable that operates in the gastrointestinal track, and has already been shown to be dramatically effective at stopping sugar before it even gets into the blood stream.

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Boston Therapeutics, Inc. (BTHE) Pioneering Treatment of Diabetes, Directed by Experienced Leader

October 29, 2013

According to the American Diabetes Association, 25.8 million children and adults in the United States have diabetes. Around 27% of that population remains undiagnosed (7 million people), and 79 million people are estimated to be classified as pre-diabetic. In 2007 alone, diabetes was either listed as an underlying cause or contributing factor to over 231,000 deaths, a stark indicator of the life-threatening risk of this condition.

Other figures show the economic impact of diabetes. According to figures supplemented in March 2013, the total costs of diabetes in the United States in 2012 was $245 billion, of which $176 billion was classified as direct medical costs and $69 billion classified as costs arising from diabetics’ reduced quality of life. After they made adjustments for population and sex differences, researchers found that people with diagnosed diabetes spent 2.3 times more on medical expenditures than those without diabetes.

In other words, it’s clear that diabetes is a well-entrenched health risk in just America alone. With leading diabetes complications such as heart disease and high blood pressure on the rise, the need for effective therapeutic treatment as well preventive measures is becoming increasingly more mainstream and compelling.

Boston Therapeutics, billing itself as “a pharmaceutical company focused on the development, manufacturing and commercialization of novel compounds based on complex carbohydrate chemistry to address unmet medical needs in diabetes,” is working to develop a solution that exhibits potential in being a pioneering solution to the ever-growing diabetes outbreak. That solution is namely the company’s PAZ320, a non-systemic, non-toxic, chewable drug for prevention of diabetes and its complications. This polysaccharide targets enzymes that digest sugar during digestion, thereby reducing the amount of available glucose for the intestine to absorb. This capability positions the PAZ320 as a prospective solution for slowing the onset of Type 2 diabetes and/or the development of diabetes complications (e.g., heart disease, stroke, kidney damage, retinopathy, and Diabetic Foot).

In addition to exhibiting strong potential in its R & D efforts, Boston Therapeutics is also led by a highly experienced and successful management and scientific advisory team with lengthy expertise in complex carbohydrate chemistry, regulatory, and clinical development. The team’s members have had numerous marked successes in submitting and obtaining approval for multiple drug candidates to the U.S. Food and Drug Administration. Collectively Boston Therapeutics’ executive management team has more than 100 years of combined experience of c-level executive leadership, corporate finance and company operations finessing, bio-medical product innovation, and corporate consulting, among other field focuses.

To illustrate Boston Therapeutics’ leadership expertise, consider Dr. David Platt, chairman, CEO, CFO and company director. He is a world-renowned expert in carbohydrate chemistry and has founded three publicly held companies, generating almost $1 billion for shareholders in those enterprises. He has also led two drug candidates from concept to human clinical trials.

With a strongly experienced management and medical science advisory board behind its efforts, and the strong potential that its PAZ320 might hold for treating diabetes, Boston Therapeutics is positioned at the threshold of delivering one of the most far-reaching innovations in bio-medical solutions in decades, and enjoying the strong profitability that would come with such an accomplishment.

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Boston Therapeutics, Inc. (BTHE) and America’s Sugar Monster

October 25, 2013

The formal description for Boston Therapeutics is of a pharmaceutical company focused on the development of novel compounds based on complex carbohydrate chemistry to address unmet medical needs in diabetes. But the company’s potential, as an investment and in terms of its possible effect on the tens of millions of people with Type 2 diabetes, is far more dramatic. CEO David Platt is blunt about it, saying in a recent interview with the New Hampshire Union Leader that “We believe that what we have in our hands is an absolute blockbuster.

The blockbuster in question is the company’s one-of-a-kind proprietary polysaccharide, PAZ320, that represents a totally new way of treating Type 2 diabetes, currently afflicting over 25 million people in the U.S. alone. PAZ320 is a chewable, locally acting complex carbohydrate-based compound that works in the gastrointestinal tract to directly block the enzymes that digest sugar. The demonstrated result is a dramatic reduction in the amount of glucose in the blood stream from carbohydrate rich meals. A phase II study of PAZ320 showed a 40 percent reduction of post-meal glucose in the blood of 45 percent of patients treated with PAZ320. There’s never been anything like it.

In spite of the enormous possibilities for Boston Therapeutics, Platt seems even more enthused about the development’s potential benefit for public health. With obesity becoming the country’s number one health issue, and even young people being faced with type 2 diabetes at levels never before experienced, Platt has an almost missionary zeal for taming the nation’s sugar monster. In the same newspaper interview, he emphasized the deadly and critical nature of the challenge, saying “It’s very simple. Sugar kills. End of story.

For additional information, visit the company’s website at www.BostonTI.com

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Boston Therapeutics, Inc. (BTHE) to Present at Livingston Securities Advanced and Nano Life Sciences Summit

October 16, 2013

Boston Therapeutics today announces it will be making a presentation on a corporate update at the Livingston Securities Advanced and Nano Life Sciences Summit. The presentation is to be given by the President of Boston Therapeutics, Kenneth A. Tassey, Jr., on October 17, 2013, in New York City.

Mr. Tassey, Jr. will cover Boston Therapeutics’ product pipeline, including PAZ320. Other topics of discussion to be covered during the presentation include the company’s product to reduce post-meal glucose elevation as well as other corporate developments. The presentation will be available on Boston Therapeutics’ website: http://ir.stockpr.com/bostonti/overview.

Headquartered in Manchester, NH, Boston Therapeutics develops drugs that address diabetes using complex carbohydrate chemistry. Specifically the company is focused on development and commercialization of therapeutic molecules that address Type 2 diabetes. The company’s initial product pipeline consists of:

• PAZ320, a non-systemic, non-toxic, chewable drug candidate for prevention of diabetes and its complications. PAZ320 inhibits the enzymes that release glucose from complex carbohydrates in foods during digestion, reducing the amount of available glucose absorbed through the intestine.
• IPOXYN™, a glyco-protein based therapeutic agent using proprietary processes and patented technology. IPOXYN™ is an anti-necrosis drug that consists of a stabilized glycoprotein composition containing oxygen-rechargeable iron, targeting both human and animal tissues and organ systems deprived of oxygen and in need of metabolic support.
• OXYFEX™, a product that can serve as the only available oxygen delivery mechanism for animals suffering ischemia or traumatic and surgical blood loss events.

The company is backed by a highly experienced and insightful management and scientific advisory team that has extensive expertise in complex carbohydrate chemistry, regulatory, and clinical development, with multiple submissions and approvals to U.S. Food and Drug Administration. Its executive management team has more than 100 years of combined experience.

For more information, visit www.bostonti.com

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Boston Therapeutics, Inc. (BTHE) Begins Research Study on PAZ320 at University of Minnesota

October 15, 2013

Boston Therapeutics today announces it has initiated a research study with the University of Minnesota on PAZ320, a complex carbohydrate-based drug designed to reduce the elevation of post-meal blood glucose by blocking the action of carbohydrate-hydrolyzing enzymes. Entitled “NMR studies of PAZ320 with sugar hydrolyzing enzymes”, the study will be conducted by Kevin H. Mayo, Ph.D., a professor in the Department of Biochemistry, Molecular Biology, and Biophysics at the University of Minnesota, Minneapolis.

Dr. Mayo commented, “PAZ320 appears to be a promising compound in the treatment of diabetes and deserves closer evaluation by the scientific community. This Boston Therapeutics-supported investigation is designed to assess biomolecular interactions between PAZ320 and various sugar hydrolyzing enzymes, and should contribute to understanding PAZ320’s mechanism of action on the molecular level.”

David Platt, Ph.D., Chief Executive Officer, Boston Therapeutics, said, “We are greatly encouraged by the results obtained to date regarding the ability of PAZ320 to reduce the elevation of post-meal blood glucose. We expect this new study at the University of Minnesota will deepen our understanding of this compound on a molecular level, and strengthen our knowledge of its potential as a drug for diabetes patients.”

The study’s purpose is to provide molecular-level information on PAZ320 and its mechanism of action. More particularly, the study is intended to better characterize PAZ320 galactomannan, and assess interactions of PAZ320 with various sugar-hydrolyzing enzymes (e.g., glucosidase and maltase). Furthermore, it may produce insights into the allosteric properties of PAZ320 with enzymes, gauge the effect of PAZ320 on enzyme-mediated sugar hydrolysis, and compare PAZ320 with other diabetes drugs.

Boston Therapeutics is a developer of drugs based on complex carbohydrate chemistry to treat diabetes. It is primarily focused currently on developing and commercializing therapeutic molecules for Type 2 diabetes, of which PAZ320 is one.

For additional information, visit www.BostonTI.com

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Article Highlights Major Investment Points for Boston Therapeutics, Inc. (BTHE)

October 11, 2013

A recent BiotechStockTrader.com article (http://dtg.fm/SyR6), highlighting the unique and positive position that Boston Therapeutics now holds with regard to the multi-billion dollar diabetes drug industry, laid out the reasons why investors are starting to jump on board the still small biotech company.

The company’s lead drug candidate, PAZ320, is the first diabetes drug to be based upon an important new technology, carbohydrate hydrolyzing enzyme inhibiting (CHEI). Unlike traditional diabetes drugs, PAZ320 doesn’t require insulin injections, and doesn’t involve interaction with important internal organs, such as the pancreas, kidneys, or liver. Instead, it is a simple chewable that operates in the gastrointestinal track, and has already been shown to be dramatically effective at stopping sugar before it even gets into the blood stream.

The article pointed out a number of reasons that Boston Therapeutics could be the next hot drug stock:

• Diabetes drugs are huge money makers, with the top 10 diabetes drugs generating well over $1 billion in annual sales, in some cases over $6 billion.

• The overall diabetes drug market is expected to grow to $58 billion by 2018.

• The number of people with diabetes has exploded over the past 10 years, and is expected to climb to over ½ billion by 2030.

• Type 2 diabetes, that targeted by Boston Therapeutics, represents approximately 95% of all diabetes cases.

• Being the first CHEI diabetes drug, Boston Therapeutics’ PAZ320 is clearly differentiated.

• In a Phase II clinical trial of PAZ320 at Dartmouth, 45% of the Type 2 diabetes patients showed a whopping 40% reduction in post-meal glucose.

• PAZ320 is easier to administer, being a simple chewable, and could avoid serious side effects sometimes found in standard drugs that that must interact with vital organs.

• PAZ320 has been shown to be effective regardless of other medications being used by the patient.

For additional information, visit www.BostonTI.com

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Boston Therapeutics, Inc. (BTHE) is “One to Watch”

October 4, 2013

Boston Therapeutics is a pharmaceutical company focused on the development and commercialization of novel compounds based on complex carbohydrate chemistry to address unmet medical needs. An IP portfolio solidifies the company’s position in the pharmaceutical industry. Boston Therapeutics’ current product pipeline, PAZ320 and IPOXYNT, is comprised of therapies developed to treat patient populations with Type 2 diabetes.

PAZ320 is a non-systemic, non-toxic, chewable drug candidate for prevention of diabetes and its complications. PAZ320 inhibits the enzymes that release glucose from complex carbohydrate in foods during digestion. Boston Therapeutics believes PAZ320 is a safe and effective drug compound for people with pre-diabetes and diabetes in their daily management of blood glucose levels, fulfilling an unmet medical need. PAZ320 has completed a Phase ll clinical trial at Dartmouth Medical Center. 45% of the patients responded with a 40% reduction in the elevation of post meal blood sugar compared to baseline with no serious adverse events.

IPOXYNT, a universal oxygen carrier, is an injectable Rx for prevention of necrosis and treatment of ischemic conditions which may lead to necrosis. This compound is not a biologic, but a second generation New Chemical Entity HBOC (hemoglobin based oxygen carrier). The potential for this product goes well beyond Lower Limb Ischemia into a range of areas from anemia and blood loss (injury), to cardiovascular disease and surgical blood supplementation.

The Boston Therapeutics management and advisory team has extensive expertise in complex carbohydrate chemistry, regulatory affairs, and clinical development, with multiple submissions and approvals to U.S. Food and Drug Administration. Backed by a team with more than five decades of expertise in public and private business management, the company is well positioned to advance its status as a premier developer of complex carbohydrate-based new chemical entities.

Let us hear your thoughts: Boston Therapeutics, Inc. Message Board

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