Category Archives: International Stem Cell Corp. ISCO

International Stem Cell Corp. (ISCO) Injection of Ethically-Derived Neural Stem Cells for the Treatment of Parkinson’s to Be Tested in Australia

November 23, 2015

The true forefront in medicine today is a broad offensive where medical and research professionals are now pulling out all the stops in a never-ending war against broad-spectrum degenerative diseases like cancer or degenerative diseases of specific tissues, such as Parkinson’s and Alzheimer’s, which severely cripple a patient’s central nervous system (CNS). Unfortunately, there is very little in the way of truly therapeutic options for patients with degenerative CNS diseases.

In the case of Parkinson’s, dopamine-generating neurons in the midbrain (substantia nigra) progressively die off, resulting in a variety of motor control issues (dyskinesia) at first, with dementia, insomnia, and severe depression or emotional problems typically following in later stages. There is no currently known cure for Parkinson’s and the standard of care consists primarily of medications designed to manage and/or provide relief from the symptoms.

The main family of drugs used to offset Parkinson’s symptoms is Levodopa (L DOPA, which metabolizes into dopamine), but MAOIs (monoamine oxidase inhibitors) and dopamine agonists have seen a significant increase of use in recent years as a first choice, in order to prolong the start of L DOPA treatment. For you see, prolonged use of L DOPA typically results in dyskinesia that is equivalent to the long-term effects of Parkinson’s itself.

Because less than 10 percent of L-DOPA actually makes it through the blood-brain barrier, the vast majority of it is metabolized elsewhere in the body, resulting in numerous side effects like nausea and joint stiffness, in addition to the aforementioned Parkinson’s-like motor control problems. MAOIs, historically already in wide usage as a treatment for atypical depression, are pretty effective at delimiting the primary monoamine oxidase that degrades dopamine, MAO-B, and thus are able to somewhat offset the lack of dopamine that is being caused by neuronal loss.

As you can see, the only solutions for Parkinson’s patients which are currently available aren’t really solutions at all, and carry with them the looming inevitability of a lost battle against this degenerative disease. A truly disheartening reality for patients and their families. Long-term options for Parkinson’s patients and their families are severely limited as well and include invasive surgery, or palliative care designed merely to improve quality for end of life patients. Reasonable extrapolations from official Parkinson’s Disease Foundation data indicates that the number of people on earth currently suffering from the disease is likely close to, or over 10 million. Some 60,000 or more people in the U.S. alone are diagnosed with Parkinson’s each year, meaning the real number is likely much higher, after factoring in all the cases that go undiagnosed, and unreported.

Hence the undisputable potential value of the proprietary, scalable and ethical human parthenogenetic (asexual reproduction from unfertilized egg) stem cell (hpSC) technology currently being developed by International Stem Cell Corp. (OTCQB: ISCO). Because hpSCs are self-renewing multipotent cells, they represent an as-yet essentially untapped goldmine of therapeutic developments which could provide solutions for countless degenerative diseases, and do so across multiple tissue types. The company’s hpSC platform for chemically stimulating eggs to reproduce, which uses a series of different activation techniques in order to create sizeable batches of healthy adult cells that are HLA/immune-matched (human leukocyte antigen) either to the individual or to the general population, has led to an exciting novel therapeutic cellular product consisting of human parthenogenetic neural stem cells (hPNSCs).

Because hPNSCs have been shown to be able to actually differentiate into dopaminergic neurons, therapy using these injected cells represents a wholly-new approach to the problem of Parkinson’s, wherein the root cause of the disease is addressed directly. Moreover, transplanted hPNSCs have been shown to express powerful brain-protecting neurotrophic factors in pre-clinical animal model studies, meaning that not only does this product hold the potential to simply grow new dopamine-producing cells, it can also help shield the remaining healthy cells from degeneration and/or death. ISCO’s recent announcement that the company is now moving full steam ahead towards phase I/IIa human clinical trials in Australia, subsequent to a meeting with the Australian Therapeutics Goods Administration and signage of an LOI with the conducting facility, Royal Melbourne Hospital, is a major milestone for the company. A milestone that puts ISCO squarely in the pole position for developing the first true Parkinson’s therapy.

TGA approval for the phase I/IIa clinical trials is expected sometime this month, with enrollment commencing shortly after, and ISCO could have a real winner on its hands depending on whether the results jog with those generated by the preceding nine-month safety GLP study of 300 rodents, which showed zero tumor growth in any of the subjects receiving transplanted cells. ISCO seems to have overcome the two major stumbling blocks that have hindered other developers in this field: immune-related tissue rejection and tumor formation.

The chemically close-to-nature methodology whereby the company generates its hpSCs is likely a main reason its therapies have had such preclinical successes, and one need look no further than the results for the other candidates (such as those for metabolic liver and degenerative eye diseases) in ISCO’s therapeutic pipeline in order to get a good idea of where the Parkinson’s therapy is headed. A savvy observer will note that the probability of success for ISCO with its hPNSC phase I/IIa clinical trials is telegraphed readily by the demonstrated versatility of the platform in allowing for a robust pipeline of several promising indications. The hpSC platform looks solid and ISCO could have one or two disruptive commercial breakthroughs on its hands in the near future.

Unlike many preclinical biopharma developers, ISCO has a cash pipeline already in place to help fund the expensive work of drug trials, with two wholly-owned subsidiaries that benefit from the company’s hpSC platform: Lifeline Cell Technology and Lifeline Skin Care. Respectively engaged in the sale of human cell culture products/reagents, as well as cosmeceuticals based on a proprietary extract derived from hpSCs, these two profitable subsidiaries not only help feed the R&D machine that is ISCO, they represent promising long-term opportunities in and of themselves. Quarterly financial data out as of November 16 from ISCO shows that Lifeline Cell Technology sales were up handsomely in Q3 (ended September 30), climbing 22 percent compared to the same quarter last year, alongside a nine percent jump in the company’s total consolidated revenue over the same period. Having wound down its multiple preclinical studies during the first six months of 2015, ISCO has managed to slash its cash burn rate and the company is now eager to see the fruits of its labor emerge from human clinical trials of hPNSCs in Parkinson’s.

The ability to grow functional, immune-matched adult human stem cells without the need to fertilize an egg is as ground-breaking a revolution in medicine as it sounds. And ISCO is basically the tip of the spear here too, alongside a tiny handful of other companies, many of whom lack the crucial IP and pre-clinical success story to deliver on a platform solution that could eventually hit hard and fast across the gamut of degenerative and similar diseases.

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International Stem Cell Corp. (ISCO) Posts Key Business Highlights, Opens its Books for Q3, YtD 2015

November 16, 2015

International Stem Cell Corp. this morning posted a business update along with operating results for the three- and nine-month periods ended September 30, 2105. Among other results, the California-based biotech company reported an increase in quarterly revenues, along with significantly narrowed third-quarter and nine-month losses.

“Overall I am satisfied with the company’s progress in Q3. We are maintaining our position as a leader in regenerative medicine field and the overall operating income of our biomedical businesses continues to grow,” Andrey Semechkin, Ph.D., CEO and co-chairman of ISCO, stated in the news release. “We really look forward to beginning the enrolment of patients in our pending Parkinson’s disease clinical trial before the end of 2015.”

Q3 Business Highlights

Among several quarterly business highlights, ISCO in the third quarter of 2015 developed an innovative technology designed to generate functional articular cartilage from the patient’s own skin or adipose tissue with the potential to treat osteoarthritis. The company also moved into the second phase of its existing research agreement with global Japanese pharmaceutical company Rohto Pharmaceutical Co., Ltd.; appointed a new chief executive officer; and presented comprehensive findings from Parkinson’s disease program at the Society for Neuroscience Annual Meeting, Neuroscience 2015.

In regards to its wholly owned subsidiary, ISCO in the third quarter completed clinical testing of a new compound, which the company intends to utilize in substantially new skin care products to be marketed by its subsidiary Lifeline Skin Care, Inc., starting December 2015. Lifeline Skin Care launched its ProPlus+ professional line of products that will be available exclusively through Lifeline’s network of dermatologists, aestheticians and med spas.

Q3, YtD Financial Results

For the quarter ended in September 2015, ISCO reported revenues of $2.14 million, an increase of 9% over revenue of $173,000 posted in the third quarter of 2014. The company’s Lifeline Cell Technology sales increased by 22%, or $220,000, while Lifeline Skin Care sales decreased by 5%, or $47,000; both wholly owned subsidiaries remain profitable. ISCO’s consolidated net loss for the quarter was $539,000 compared to consolidated net loss of $2.0 million for the third quarter last year.

Total consolidated revenue for the nine months ended September 30, 2015, was $5.57 million, an increase of 7%, or $373,000, vs $5.20 million in revenue reported for the comparable period of 2014. Lifeline Cell Technology sales increased by 9%, or $244,000, while Lifeline Skin Care sales decreased by 5%, or $129,000. ISCO’s consolidated net loss for the nine months ended September 30, 2015, was $1.1 million vs a consolidated net loss of $7.9 million for the comparable nine months of last year, which the company partially attributes to the completion of multiple preclinical studies during the first six months of 2015.

ISCO ended the third quarter of 2015 with cash balance of $599,000. As of September 30, 2015, stockholders’ equity totaled $834,000.

Using its core technology, which results in the creation of pluripotent human stem cells from unfertilized oocytes (eggs), ISCO is focused on the therapeutic applications of human parthenogenetic stem cells (hpSCs) and the development and commercialization of cell-based research and cosmetic products. ISCO scientists have created the first parthenogenetic, homozygous stem cell line that can be a source of therapeutic cells for hundreds of millions of individuals of differing genders, ages and racial background with minimal immune rejection after transplantation. hpSCs offer the potential to create the first true stem cell bank, UniStemCell™. ISCO also produces and markets specialized cells and growth media for therapeutic research worldwide through its subsidiary Lifeline Cell Technology (, and stem cell-based skin care products through its subsidiary Lifeline Skin Care (

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International Stem Cell Corp. (ISCO) Bypasses Embryonic Ethical Debates by using Non-Embryonic Stem Cells for Research

November 9, 2015

The ethical controversy surrounding stem cell research does not reach the International Stem Cell Corp. as it employs non-embryonic cells (unfertilized) for exploring and attempting to treat different diseases. The company has developed the first collection of non-embryonic human stem cells that are stored in the UniStemCell Bank. When properly stimulated, the unfertilized eggs begin dividing into usable cells called human parthenogenetic stem cells (hpSC). The process, called parthenogenesis, creates stem cells that are self-renewing and have high potential for being compatible with a large portion of the population. A single cell line can treat millions of people with a low risk of immune rejection, a common issue in stem cell therapies. The company intends to use this system on eye, nervous system, and liver diseases with high expectations for successful results.

The controversy surrounding embryonic stem cell research begins with the view that life starts at conception with the embryo. The formation of a human stem cell line means the destruction of a human embryo. Therefore, the rights and status of an embryo are called into question.

Fortunately, the International Stem Cell Corp. side steps this controversy by using unfertilized embryos in its research. Stem cells have the capability of becoming any and all types of cells in the body, making them invaluable when combating degenerative diseases. However, the use of non-embryonic adult stem cells produces the possibility of immune rejection while embryonic cells lessen that chance. The company’s production of human leukocyte antigen genes (HLA) from parthenogenesis greatly diminishes this risk while keeping an ethical advantage.

The rapid division of these cells into usable regenerative ones means potentially effective cellular replacement therapies. The company has developed treatments for liver and retinal diseases that replace aged or damaged cells with newer ones. The company also recently announced its progression with clinical trials in treating Parkinson’s disease in Australia.

The International Stem Cell Corp. continues its goal of developing innovative restorative stem cell treatments for diseases that cause deterioration.

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International Stem Cell Corp. (ISCO) Advances Parkinson’s Disease Clinical Trials in Australia

November 3, 2015

California-based International Stem Cell Corporation this morning announced that its wholly owned subsidiary, Cyto Therapeutics, has signed a Letter of Intent (LOI) with Royal Melbourne Hospital in Australia to conduct phase I/IIa clinical trials of ISCO’s proprietary human parthenogenetic neural stem cells (hPNSCs) for the treatment of Parkinson’s Disease.

The LOI follows a recent meeting with Australian Therapeutics Goods Administration (TGA), and precedes a full agreement expected to be signed after TGA and the HREC approve the clinical protocol for the trials.

“We had a productive meeting with TGA where we discussed the clinical protocol and potentially came to an agreement on all remaining items. We look forward to receiving TGA approval for clinical trials in November and enrolling patients soon thereafter,” Russell A. Kern, Ph.D., chief scientific officer of ISCO, stated in the news release.

ISCO’s Parkinson’s disease program uses hPNSCs, a novel therapeutic cellular product derived from the company’s proprietary human pluripotent stem cells. hPNSC are self-renewing multipotent cells that are precursors for the major cells of the central nervous system. The cells’ ability to differentiate into dopaminergic neurons and express neurotrophic factors to protect the nigrostriatal system creates a potential new opportunity for the treatment of Parkinson’s disease.

Additionally, hpSCs offer the potential to create the first true stem cell bank, UniStemCell™. ISCO also produces and markets specialized cells and growth media for therapeutic research worldwide through its subsidiary Lifeline Cell Technology (, and stem cell-based skin care products through its subsidiary Lifeline Skin Care (

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International Stem Cell Corp. (ISCO) Also Develops Advanced Stem Cell Technology for Skin-Deep Results

October 27, 2015

A leader in regenerative medicine, International Stem Cell Corp. uses its parthenogenesis stem cell technology to address immune rejection and self-renewing cells. This technology uses unfertilized eggs that have cells with a duplicate set of human leukocyte antigen genes (HLA) that lessen the chance of a body rejecting cells. From this, scientists created self-renewing human parthenogenetic neural stem cells (hpNSC).

These cells have the capacity to replace dead and dying neurons while protecting existing ones in patients with Parkinson’s disease. In fact, the company recently presented its preclinical results for the treatment of the disease at Neuroscience in Chicago. Furthermore, scientists with the company are currently developing cell technology to treat liver and retinal diseases.

The International Stem Cell Corp. also has a hand in anti-aging skin care products that uses its stem cell technology through its subsidiary Lifeline Skin Care. This technology is based on the communication between human cells. Protein molecules can carry messages that tell the surrounding cells to create new cells for tissue repair. The company removes those proteins from the parthenogenetic stem cells then creates microscopic bubbles called nanospheres to protect them from exposure. These tiny bubbles are then infused with vitamins, minerals, moisturizers, and antioxidants to create a finished serum.

Lifeline Skin Care has a range of products that include overnight, daily, neck and eye firming, and cleanser creams that can improve the look and feel of skin.

The innovative stem cell based technology of the company is not limited to degenerative diseases of the body. Skin can also benefit from parthenogenesis through the addition of healthy cells that prevent the look of aging though rejuvenation. Proceeds from the skin care line help support research for Parkinson’s, liver, and blindness diseases.

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International Stem Cell Corp. (ISCO) Stays the Course in BioTech’s Regenerative Medicine Space

October 20, 2015

International Stem Cell Corp. continues its pursuit of advancing regenerative medicine through its use and research of stem cells in the white hot biotechnology space. ISCO uses parthenogenesis, a stem cell technology that makes use of unfertilized eggs to address immune system rejection. The eggs being used have mirroring sets of human leukocyte antigen genes (HLA) that reduce the chance of immune system rejection. Not to be overlooked, it’s worth noting that one line of these cells can treat multiple millions of people. The company can draw human parthenogenetic neural stem cells (hpNSC) from the unfertilized eggs for self-renewing processes that are integral to the degeneration process.

Following continuous successful testing, International Stem Cell Corp. suggests that their human parthenogenetic neural stem cells can take the place of dead and dying neurons while also protecting existing ones when transplanted into the brain of someone with Parkinson’s disease. Further, company researchers and scientists are progressing toward developing human retinal epithelium (RPE) cells that are used in the treatment of eye diseases like age-related macular degeneration. Along with that research, the company is one of the world’s select few to develop a method for creating corneal tissue and cells to treat blindness.

International Stem Cell has recently announced its development of technology that creates functional cartilage from a person’s skin to treat a joint disease that erodes cartilage infamously known as osteoarthritis. The company is also making strides aside from therapeutic systems that, according to Chief Scientific Officer, Ruslan Semechkin, PhD, “can potentially be treated with the patient’s own cells.”

Running concurrent with its work in the area of regenerative techniques, International Stem Cell Corp. runs a cosmeceutical line called Lifeline Skin Care Inc. This business makes cosmetic skin care products all over the globe. The company’s research and development in this area uses parthenogenetic stem cells, vitamins and minerals to create a rejuvenating serum leading to healthier skin.

International Stem Cell Corp. works on therapeutic applications of human parthenogenetic stem cells and the development and commercialization of cell-based research and cosmetic products. The company’s primary technology of parthenogenesis nets the creation of pluripotent human stem cells from unfertilized oocytes. Company scientists have created the first parthenogenetic, homozygous stem cell line that is considered by many to be a source of therapeutic cells for hundreds of millions of individuals of differing genders, racial background and ages.

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International Stem Cell Corp. (ISCO) to Present Comprehensive Findings for Parkinson’s Disease Program Preclinical Studies at Society for Neuroscience Annual Meeting

October 14, 2015

International Stem Cell Corp., a California-based biotech company developing novel stem cell-based therapies and biomedical products, this morning said it will make an oral presentation on the comprehensive results of its preclinical development of human parthenogenetic neural stem cells (hPNSCs) for the treatment of Parkinson’s Disease at the upcoming Neuroscience 2015 in Chicago.

The session, entitled, “Therapeutics of Parkinson’s Disease: Preclinical Studies,” will take place October 20 from 8 a.m.-10:15 a.m. ET.

“The comprehensive data collected from our extensive GLP studies serve as proof of safety and efficacy for our planned clinical trial for the treatment of Parkinson’s Disease in Australia. We look forward to providing an update on the status of our regulatory submission to the Australian government in the near future,” Russell A. Kern, Ph.D. chief scientific officer of ISCO, stated in the news release.

ISCO’s Parkinson’s disease program uses human parthenogenetic neural stem cells (hPNSC), which are a novel therapeutic cellular product derived from ISCO’s proprietary human pluripotent stem cells. hPNSC are self-renewing multipotent cells that are precursors for the major cells of the central nervous system. The ability of hPNSC to differentiate into dopaminergic neurons and express neurotrophic factors to protect the nigrostriatal system offers a new opportunity for the treatment of Parkinson’s disease.

ISCO also produces and markets specialized cells and growth media for therapeutic research worldwide through its subsidiary Lifeline Cell Technology (, and stem cell-based skin care products through its subsidiary Lifeline Skin Care (

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International Stem Cell Corp. (ISCO) Continues Stem Cell Based Research and Development to Promote Rejuvenation of Dying Cells

October 6, 2015

The International Stem Cell Corporation, a biotechnology company, continues its developmental research of using stem cells to advance regenerative medicine. The company uses stem cell technology called parthenogenesis that uses unfertilized eggs to address immune system rejection. These eggs have duplicate sets of human leukocyte antigen genes (HLA) that lessen the chance of immune rejection. A single line of these cells can treat millions of people. Furthermore, ISCO can draw hpNSC (human parthenogenetic neural stem cells) from the unfertilized eggs for self-renewing processes related to degeneration.

For example, after continuous successful testing, ISCO believes that their hpNSC can replace dead and dying neurons while also protecting existing ones when transplanted into the brain of someone with Parkinson’s disease. Likewise, ISCO scientists have taken steps to develop human retinal epithelium (RPE) cells that can treat many eye diseases like age-related macular degeneration. Along with that research, the company is among the first in the world to develop a method (CytoCor) for creating corneal tissue and cells to treat blindness.

ISCO recently announced its development of technology that creates functional cartilage from a person’s skin to treat osteoarthritis, a joint disease that erodes cartilage. The company is also pursuing other therapeutic systems that “can potentially be treated with the patient’s own cells,” said its chief scientific officer, Ruslan Semechkin, PhD.

While continuing to develop new regenerative techniques, ISCO also maintains a cosmeceutical line called Lifeline Skin Care Inc. This business manufactures cosmetic skin care products around the world. It uses parthenogenetic stem cells along with vitamins and minerals to create a rejuvenating serum that promotes healthy skin.

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International Stem Cell Corp. (ISCO) Develops Breakthrough Technology to Treat Osteoarthritis

September 30, 2015

International Stem Cell Corp., a biotechnology company developing novel stem cell-based therapies, announced that its scientific team has developed a robust innovative technology to generate functional articular cartilage from the patient’s own skin or adipose tissue to treat osteoarthritis. ISCO believes this technology may allow the company to provide relief to patients suffering from osteoarthritic knee joints, as well as to those with shoulder joints and intervertebral spinal disk osteoarthritis.

Ruslan Semechkin, ISCO’s chief scientific officer, stated, “While we are working on obtaining regulatory approval for the Parkinson’s disease treatment in Australia, as well as in the US, we are also pursuing a number of other therapeutic indications including osteoarthritis, which can potentially be treated with the patient’s own cells.”

Even though osteoarthritis is prevalent in our society, there is a lack of an effective treatment for this disease. Developing and successfully testing a scalable system that permits the generation of functional human cartilage tissue with superior mechanical properties is a significant accomplishment. The capacity to provide greater stability than other tissue that is currently available for the treatment of osteoarthritis is even more impressive.

Osteoarthritis is a degenerative joint disease characterized by progressive erosion of the articular cartilage. Although osteoarthritis can damage any joint in the body, the disorder most commonly affects joints in the hands, knees, hips and spine. The erosion of articular cartilage leads to joint pain, stiffness, and impaired mobility. According to the Arthritis foundation osteoarthritis affects over 27 million Americans with an estimated medical costs of as much as $65 billion.

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International Stem Cell Corp. (ISCO) Stem Cell Therapy Commercialization Progress on the Verge of Major Milestones

September 28, 2015

Stem cell technology’s real untilled and still extremely fertile soil is the therapeutics market, where injected cells could help repair damaged tissue systems and thus effectively treat many conditions, including degenerative ones, for which the current standard of care is often palliative at best. Dealing with the underlying cause of a given condition, through the gradual replacement and/or reinforcement of an impaired tissue system or organ using injected stem cells, represents a true paradigm shift in how we think about treating many of today’s most debilitating diseases. However, to tap into the rich spoils of this as yet largely undiscovered country, requires a mix of technologies and logistical capabilities, of which tragically few companies today can seriously boast.

One company that doesn’t need to boast, as it has clearly achieved both the capacity to proprietarily differentiate adult human cells by chemically stimulating unfertilized donor eggs, as well as provide long-term, storable, high-quality stem cell product for real-world, commercial-scale therapeutic applications, is International Stem Cell Corp. At the core of the company’s pipeline of rapidly emerging therapeutics is its parthenogenesis technology, whereby the company can create large batches of pluripotent (able to develop into any type of cell), human parthenogenetic stem cells (hpSCs), and do so in a completely ethical fashion. The company’s proprietary stimulation and differentiation technology also helps resolve the one major stumbling block facing stem cell therapies, immune rejection by the host. The company’s ability to make large batches of adult human cells from stem cells that are either specifically immune-matched to the donor, or immune-matched to the general population, gives ISCO an open road to therapy development, and the company has the testing to back up its technology too.

ISCO’s nine-month, 300 subject rodent model safety study, testing the tumorigenicity (propensity to promote tumor formation/growth) of its human neural stem cells (hpNSCs), which have been developed for the treatment of Parkinson’s disease (PD), was submitted back in July as part of the build up to phase 1/2a human clinical trials in Australia. This study followed up on earlier results by ISCO with its hpNSCs, showing no tumors in any of the animals receiving neural stem cell transplants. The demonstrated ability of injected hpNSCs to create new neurons that produce the primary neurotransmitter, dopamine (with whose falloff PD is causally associated), as well as exhibit a neuroprotectant effect on surviving neurons makes this technology a potential gold mine if human clinical trials yield good results.

Given that PD is a progressive, degenerative disorder, and that the current standard of care, oral levodopa (L-dopa), is associated with progressively worse periods where symptoms manifest themselves fully, called “off” periods, there hasn’t really been a good long-term solution for addressing the unmet needs of a majority of PD patients. This majority of PD patients, for whom the current standard of care so often feels like they are just postponing the inevitable succumbing to the disease’s impairments, are plagued by the frequency and intensity of relapse periods increasing as the disease progresses using L-dopa. ISCO isn’t trying to mask the problem chemically with synthetic dopamine, the company has developed injectable replacement neurons to treat the underlying brain tissue degeneration, and hopefully actually restore full functionality to the patient.

According to a new study out by research and consulting firm, GlobalData, the PD treatment market for just the U.S., Brazil, Japan, and the major EU member states is on track to hit upwards of $4.7 billion by 2022. However, newly FDA-approved market entrants, such as Xadago (safinamide) – a drug which blocks the primary enzyme which break down dopamine, from Zambon and its SIX Swiss Exchange-traded partner Newron Pharmaceuticals (SWX: NWRN) – or Impax Laboratories’ (NASDAQ: IPXL) RYTARY, an extended-release oral capsule formulation of carbidopa-levodopa – still do not address the underlying causes of the disease. It is up to a company like ISCO to bring forth a real therapeutic treatment option here, with ethical stem cell technology that can actually regenerate the damaged tissue system(s). With PD, given its progressive nature, it is not unthinkable that periodic injections, or simply a thorough course of therapeutic treatments with hpNSCs, could restore the patient to full functionality.

A good indicator of this potential is ISCO’s parallel hpNSC therapy pipeline for stroke, where preclinical data indicates that injections administered even several weeks after the stroke could actually reverse the typically associated functional deficits completely. The alternative to such a therapy in the case of a stroke is often grueling physical therapy, required in order to get back or re-learn lost motor function. But with ISCO’s treatment option on the table, stroke could be handled in the future with a simple injection regimen, even well after the initial stroke hospitalization. The tremendous potential of hpNSC therapy in strokes speaks volumes about what that same therapy can do for PD patients, given that both are maladies of the CNS, and that the therapy functions by replacing damaged neurological tissue.

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International Stem Cell Corp. (ISCO) Appoints Ms. Ebrahimi as CFO

September 22, 2015

Today before the opening bell, International Stem Cell Corp. announced that Mahnaz Ebrahimi will be taking over as the new Chief Financial Officer, effective September 14, 2015. The prior CFO, Jay Novak, ended his employment in May.

Ms. Ebrahimi is a Certified Public Accountant, a Certified Equity Professional and a Certified Cash Manager. She has more than 25 years of experience in financial management and accounting of growing research-driven companies in the life sciences, biotechnology, and pharmaceutical sectors. Most recently, she has been assisting several biotechnology and technology companies on accounting and SEC related matters in an expert consultancy capacity, including Flux Power Holdings, Polaris Pharmaceuticals and Ocera Therapeutics.

From 2010 until an acquisition took place in 2012, Ms. Ebrahimi served as Director of Finance and Planning, as well as Treasury, of eBioscience. She also served as Vice President of Finance and Administration and Chief Financial Officer of Profil Institute for Clinical Research from 2003 to 2005. From 1989 to 2000, she served as Director of Finance & Treasury and Assistant Controller of Agouron Pharmaceuticals, which became a subsidiary of Pfizer in 2000.

For those unfamiliar with International Stem Cell Corp., it is a California-based biotechnology company focused on the therapeutic applications of human parthenogenetic stem cells (hpSCs) and the development and commercialization of cell-based research and cosmetic products. ISCO’s core technology, parthenogenesis, results in the creation of pluripotent human stem cells from unfertilized oocytes (eggs). ISCO also produces and markets specialized cells and growth media for therapeutic research worldwide through its subsidiary Lifeline Cell Technology, and stem cell-based skin care products through its subsidiary Lifeline Skin Care.

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International Stem Cell Corp. (ISCO) Immense Therapeutic Potential of Scalable, Ethically-Derived Stem Cell Tech on Display at Rodman & Renshaw

September 17, 2015

The promise of stem cell tissue transplantation is particularly exciting for conditions such as Parkinson’s disease, an incurable and progressive disorder of the nervous system characterized by a gradual at first, and then increasingly severe impairment of various motor control faculties. Parkinson’s disease makes a good poster child for the enormous potential of stem cell therapy in other diseases/conditions, because it is materially defined by a localized degeneration of neurons, making targeted replacement therapy via injected cells extremely appealing.

International Stem Cell Corporation (OTCQB: ISCO) is at the forefront of developing such therapies via its capacity to produce pluripotent (having the ability to develop into essentially any cell in the human body), non-embryonic, human parthenogenetic stem cells (hpSCs), such as its lead product candidate, human neural stem cells (hpNSCs). And because hpNSCs have produced abundant evidence thus far that they can not only differentiate into neurons that help produce the primary neurotransmitter whose falloff is associated with Parkinson’s disease, dopamine, but can also directly express neuroprotectant capabilities, the potential for treating other incurable CNS diseases like multiple sclerosis, muscular dystrophy, or Lou Gehrig’s disease, is effectively on the table.

Moreover, because the company’s proprietary technology for creating pluripotent hpSCs utilizes unfertilized eggs, which are chemically stimulated to begin the process of division before being differentiated into either patient specific human leukocyte antigen-matched and histocompatible (heterozygous) hpSCs or HLA homozygous hpSCs that are immune-matched for compatibility with the vast majority of the population, ISCO’s technology constitutes an end run on the ethical controversy that has plagued stem cell research. At the same time, because a relatively small series of human leukocyte antigen (HLA) homozygous cell lines could effectively present treatment options which are suitable for huge swathes of the human population, ISCO has at its disposal a methodology for creating commercial scale volumes of cells (for therapeutic or research purposes) that resolves the stem cell industry’s primary procedural stumbling block, immune system rejection.

This is a significant advantage when it comes to research purposes and ISCO has already taken up the lead in the sector, creating the world’s first true human stem cell bank, UniStemCell™, a growing collection of non-embryonic histocompatible stem cells. The ability to go to an “off-the-shelf” cell line from the bank that is immune-matched to millions of individuals is also key when it comes to developing frontline stem cell therapies. Hence the buzz about the company’s rapidly developing therapeutic pipeline that covers several unmet needs, like neural stem cells for treating CNS maladies such as Parkinson’s disease and stroke, liver cells for treating even severe metabolic liver diseases such as Crigler-Najjar syndrome, and corneal/retinal cells for treating corneal blindness, as well as macular degeneration.

ISCO’s ongoing development of a powerful hpNSC based therapeutic solution for Parkinson’s disease will soon see a critical milestone in the phase I/IIa clinical trial set to take place in Australia, and the company’s recently submitted animal model study, showing that no tumors were observed in a battery of 300 rodents, gives investors a really good idea about how safe and effective such injected stem cell therapy could be for humans. Already commercially successful via its Lifeline Skin Care subsidiary, which saw an 18 percent Q2 jump in YOY revenue to $1.82 million, on the strength of sustained growth for revitalizing skin care products, International Stem Cell Corporation is also dedicated to helping the life sciences industry meet its own clinical research needs by providing a vast array of specialized cells and growth media through its Lifeline Cell Technology subsidiary.

ISCO’s CSO and board member, Ruslan Semechkin, PhD, offered attendees at the Rodman & Renshaw 17th Annual Global Investment Conference a general overview of such astounding capabilities, as well as a closer look at the company’s ongoing clinical and research programs. Investors who were unable to attend the conference can still get a good front seat look at the company’s therapeutic pipeline and ongoing programs, simply by visiting the company’s website at

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International Stem Cell Corp. (ISCO) Begins Next Phase of Research Collaboration with Rohto Pharmaceutical Co., Ltd. of Japan

September 8, 2015

Today before the opening bell, International Stem Cell Corp. announced that it has entered into the second phase of the existing Research Agreement with Rohto Pharmaceutical Co., Ltd. (“Rohto”), a global Japanese pharmaceutical company recognized as the second-largest consumer health company in Japan.

Rohto acknowledged that ISCO’s human parthenogenetic neural stem cells (hpNSCs) demonstrate consistent high quality and are suitable for further use in Rohto’s research. This was determined after successfully completing preliminary studies of ISCO’s proprietary cells. If Rohto successfully validates hpNSCs’ efficacy in rodent models, which could lead to a possible treatment of a variety of degenerative eye disorders, Rohto plans to enter into negotiations of a definitive license agreement with ISCO in order to license the company’s proprietary technology for therapeutic and commercial use.

“Based on hpNSCs known performance in various animal models we expect that in the next four months Rohto will be able to demonstrate the efficacy of these stem cells in treating retinal degenerative disorders,” stated Ruslan Semechkin, Ph.D., Chief Scientific Officer of ISCO.

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International Stem Cell Corp. (ISCO): A Double Threat with Cutting-Edge, Ethically Derived Stem Cell Therapies & Commercial-Scale Biobanking

August 27, 2015

On the cusp of milestone TGA (Therapeutic Goods Administration) authorization in Australia to start clinical trials in its breakthrough Parkinson’s disease (PD) treatment using human parthenogenetic neural stem cells (hpNSCs), International Stem Cell Corp. (OTCQB: ISCO) was proud to show markets recently that the company has achieved a point of maturity where it is also driving home steadily increasing revenues. The release of the company’s Q2 2015 data also showed record net income for the quarter, with outlays decreasing due to having successfully wrapped on a number of important preclinical studies, even as revenues increased 14 percent year over year, and profit margins held steady at around 72 percent.

The company’s increasingly lucrative biomedical business and consistently profitable regenerative skin care offerings, administrated respectively via ISCO’s wholly-owned Lifeline Cell Technology and Lifeline Skin Care subsidiaries, continue to materially backstop the ongoing development of an exciting therapeutic pipeline based on proprietary human parthenogenetic stem cell (hpSC) technology which is efficient, perfect for commercial scale volumes, and also completely ethical. ISCO’s parthenogenesis technology employs a unique chemical stimulation technique for triggering unfertilized donor human eggs to create pluripotent cells that can then be differentiated through proprietary activation into numerous types of cells. From the aforementioned hpNSCs, which are increasingly seen via the company’s trial work as a paradigm shift approach when it comes to treating neurological system conditions like PD and even ischemic stroke. To liver and eye cells that can be used to effectively treat degenerative diseases affecting those tissue systems, such as metabolic liver disease and macular degeneration.

Just looking at the company’s application of hpNSCs in PD, we see a fundamentally new approach to therapy using transplanted stem cells, which could actually solve the underlying problems that give rise to such conditions, rather than just attempting to ameliorate the condition as with many other therapies, including the current standards of care. In PD, where injected hpNSCs actively differentiate into both dopaminergic neurons, as well as express brain-protecting neurotrophic factors, and thus directly address the two primary causes of debilitation, this approach shows its monumental superiority to other approaches by simultaneously replacing dead neurons and protecting any survivors. This kind of therapeutic solution constitutes an end-run on PD, and potentially many other diseases/disorders via a completely ethical, high-volume stem cell production technology, and it could make ISCO into one of the now $27 billion plus global stem cell market’s heaviest hitters.

Recent projections by Transparency Market Research indicate that the global stem cell market is just getting warmed up too. With around 24 percent CAGR seen occurring through 2018 and valuations the following year of as much as $119 billion or more, this highly fragmented market is primed for explosive growth. Something which is especially true for real innovators like ISCO, given that pluripotent stem cells are also seen as rapidly eclipsing the core adult stem cell type that currently has around 80 percent of the market share.

Perhaps even more importantly, the company’s UniStemCell bank, which is effectively the life science industry’s first commercial-scale aggregation of histocompatible, non-embryonic human stem cells, is ideally positioned to benefit from the continued upswing in the sector. Providing a growing logistical footprint of high-quality material for research purposes, as well as commercial applications. Moreover, ISCO has established a solid presence already here in the U.S., which is the epicenter of global activity for the stem cell industry due to federal government support for the sector. As the biobanking market expands further into Europe and other global markets, the company will benefit from first-mover advantages.

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International Stem Cell Corp. (ISCOD) Leading the Way in Emerging Field of Regenerative Medicine with Parthenogenetic Stem Cell Technology

August 20, 2015

International Stem Cell Corporation is a biotechnology company utilizing a proprietary new stem cell technology known as parthenogenesis to significantly advance the field of regenerative medicine. The company’s innovative technology uses unfertilized human eggs to create human pluripotent stem cells (hpSC) that can be immune-matched to millions of people around the globe. These stem cells are unique in that they provide the best characteristics of each of the remaining classes of cells without the need for the creation or destruction of a viable embryo.

The company’s business strategy features three unique channels for revenue generation within the biotechnology industry – including its core stem cell technology and related intellectual property, which encompasses 220 patents, applications and licenses associated with the development and manufacture of pluripotent cells, as well as its therapeutic research projects and promising development pipeline.

Lifeline Skin Care, the company’s wholly-owned subsidiary, is an industry leader in effective anti-aging stem cell skin care. Since being established in 2010, Lifeline has served as a growing source of vital financial support to fund ISCO’s ongoing medical research. In 2014, Lifeline accounted for more than $7 million in total revenue, which was primarily allocated to the advancement of the company’s promising development pipeline.

UniStemCell is the life science industry’s first collection of non-embryonic histocompatible human stem cells available for research and commercial use. This cell bank gives the company a nearly inexhaustible source of stem cells that can be used to generate revenue in the medium term. As the company’s hpSC lines gain additional validation, they are expected to provide the company with royalty from sales of each successful hpSC-derived cellular therapeutic in the future.

In addition to the sale of its stem cells, ISCO is making noteworthy progress toward the continued advancement of its development pipeline. The company is currently engaged in pre-clinical development addressing a host of unmet medical needs. Parkinson’s disease, which affects an estimated one million people in the United States, represents ISCO’s leading development indication, with phase I/II clinical trials expected to begin in the coming months. Following the completion of initial studies, the company will seek out a suitable partner to assist with late-stage clinical development.

With its groundbreaking stem cell technology, ISCO is developing a significant presence within the expansive field of regenerative medicine. By successfully mitigating many of the limiting factors commonly associated with stem cell research – including auto-immune rejection and ethical debate surrounding the use of embryonic cells – the company is leveraging the marketability of its technology as a catalyst for continued growth.

Research indicates that the global regenerative medicine market is expected to grow at a CAGR of 12.2 percent through 2017, climbing to an estimated $24.7 billion by the end of the period. ISCO will look to capitalize on this market performance under the guidance of an executive management team with decades of experience in a collection of related scientific sectors.

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International Stem Cell Corp. (ISCO) Posts Record Financial Results in the Second Quarter of 2015

August 18, 2015

International Stem Cell Corp. is expanding its presence in the emerging field of regenerative medicine through the development of its novel stem cell-based therapies and biomedical products. In recent months, this progress has translated into record-setting financial results, as the company has continued to position itself as a major player in the biotechnology industry.

“Stable increase in revenues from our biomedical businesses, ability to generate net income as a parent company and progress in demonstrating the safety and efficacy of our stem cells for the treatment of Parkinson’s disease and stroke position us as a leader in [the] regenerative medicine field,” Dr. Andrey Semechkin, chief executive officer and co-chairman of ISCO, stated in a news release.

In the second quarter of 2015, ISCO realized a 14 percent year-over-year increase in total revenue, recording $1.82 million. This growth was primarily fueled by the performance of the company’s subsidiary, Lifeline Skin Care, which recorded an 18 percent year-over-year increase in revenue for the period. In addition to expanding upon the customer base of its existing product lines, ISCO also completed the development and testing of two new products to be sold under the trusted Lifeline Skin Care brand moving forward. Lifeline Cell Technology, ISCO’s human cell manufacturing subsidiary, posted similar financial growth for the quarter, recording an 11 percent year-over-year increase in sales.

The company’s strong financial performance through its subsidiaries helped fund its considerable progress toward the development of its proprietary human parthenogenetic neural stem cells (hpNSCs). In preclinical testing, ISCO demonstrated the capability of its cells to significantly reduce neurological dysfunction following a stroke in animal models. Following the publication of two proof of concept studies that demonstrate the safety and efficacy of the company’s stem cell treatment techniques in both non-human primate and rodent animal models, ISCO expects to begin its Parkinson’s disease trials in the Australian market before the end of this year.

“We look forward to receiving Australian TGA authorization to start clinical trials,” continued Semechkin. “We expect to dose the first Parkinson’s disease patients in this trial in Q4 2015.”

For prospective shareholders, ISCO’s ability to generate revenue and maintain a strong cash position during clinical development programs is a promising indication of the company’s long-term viability. Look for ISCO to continue leaning on the established market presence of its subsidiaries in order to fund the ongoing clinical development of its promising Parkinson’s disease treatment program while simultaneously promoting sustainable returns.

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International Stem Cell Corp. (ISCOD) Preparing to Initiate Clinical Development for the Treatment of Parkinson’s Disease in Australia

August 11, 2015

International Stem Cell Corp. recently took a significant step toward expanding its clinical pipeline when it submitted preclinical data to the Australian Therapeutic Goods Administration (TGA) regarding its impending phase I/IIa clinical trial for the treatment of Parkinson’s disease. According to the submitted data, the company’s nine month study of 300 rodents resulted in no tumors being observed in any of the animal subjects, demonstrating the safety and efficacy of its human neural stem cells (hpNSCs), which were derived using ISCO’s proprietary parthenogenetic stem cell platform. The company predicts that this will be the final submittal required prior to the initiation of clinical studies.

“We expect that this study report will address the remaining safety elements necessary for regulatory approval,” Dr. Ruslan Semechkin, chief science officer of ISCO, stated in a news release. “Having provided this final submission we now look forward to receiving TGA authorization to begin our phase I/IIa clinical trial in Australia.”

If approved to begin clinical trials, ISCO will be in a strong strategic position to enter the Australian Parkinson’s disease treatment market in the future, which could provide the company with a substantial opportunity to achieve sustainable international growth. According to a report by Parkinson’s Queensland, approximately one in 350 Australians live with Parkinson’s disease, making it the country’s second most common neurodegenerative disorder. In 2011, the debilitating disease accounted for an estimated $480 million in national health system costs, further demonstrating the market potential of ISCO’s groundbreaking treatment option following regulatory approval.

ISCO’s proprietary approach to stem cell research, parthenogenesis, directly addresses many of the limiting factors typically associated with regenerative medicine. In particular, the company’s parthenogenetic homozygous stem cell line can be a source of therapeutic cells for hundreds of millions of individuals with minimal risk of immune rejection following transplantation. Additionally, since its cells are derived from unfertilized eggs, ISCO avoids many of the ethical issues associated with embryonic stem cells without sacrificing their transformative pluripotent qualities.

For prospective shareholders, the company’s strong progress toward expanding its market share in the global regenerative medicine industry could foreshadow an opportunity for sustainable returns in the months to come. Look for ISCO to build on this progress moving forward as it eagerly awaits TGA authorization to begin its pivotal clinical development program in the Australian market.

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International Stem Cell Corp. (ISCOD) Reports Completion of New Compound’s Clinical Testing

August 7, 2015

Yesterday, International Stem Cell Corp., a California-based biotechnology company developing novel stem cell based therapies and biomedical products, announced the completion of a recently discovered compound’s clinical testing. This compound is expected to be utilized in skin care products marketed by the company’s wholly-owned subsidiary Lifeline Skin Care, Inc.

Topical treatment with the compound showed significant (p<0.01) improvement in skin elasticity and decrease in skin roughness in all subjects 4 and 8 weeks after the start of the study. In addition, the compound-treated group outperformed not only the baseline, but also the Retinol treated group. There were no adverse events reported in the compound-treated group, such as skin irritation, which has been reported as a common side effect of Retinol treatment.

Prior to the clinical study, the compound was tested on different in vitro models: normal human keratinocytes, fibroblasts and 3D model of human skin. In all these models, the recently discovered compound induced up to twice the production of elastin and collagen compared to Retinoic Acid (the active form of Retinol) with none of its toxic characteristics.

The launch of the compound-based products is expected this year. Currently Lifeline markets its stem cell-based skin care in the US and Asia via professional and on-line retail channels ( The company believes that these new compound-based products will not only allow it to increase sales and profit margins in its existing markets, but also will allow it to enter the European “high-tech” skin care market.

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International Stem Cell Corp. (ISCOD) Prepares To Up-List, Tightens Share Structure Ahead of Landmark Parkinson’s Clinical Trial

August 5, 2015

With the success of its nine-month GLP safety (tumorigenicity) and biodistribution animal model study in Parkinson’s Disease (PD) showing a completely clean record, as zero tumor growth was observed across a batch of 300 rodents injected with the company’s ethically and proprietarily-derived human neural stem cells (hpNSCs), International Stem Cell Corp. has subsequently taken a major step to increase the company’s market presence and up-list to a major exchange, announcing a reverse stock split in order to tighten the overall share structure. Since the July 29 split announcement, the company’s ticker has been ISCOD, and it will remain so until the typical period of approximately 20 days has elapsed.

The recently completed nine month GLP safety study, which capitalizes on a long track record of successfully demonstrated results stretching back to such examples as the 2013 work with Duke University’s Clinical Research Institute, was the last step needed for International Stem Cell to secure the previously announced landmark phase 1/2a clinical trial in PD with the Australian Therapeutic Goods Administration via the company’s recently-formed Australian subsidiary, Cyto Therapeutics Pty Ltd. The company has quite a preclinical dataset to back up its novel approach to treating PD with injected hpNSCs, which are self-renewing multipotent precursor cells to the main types of cells that make up the CNS (central nervous system), created using the company’s proprietary parthenogenetic technology, which chemically differentiates unfertilized human eggs (oocytes) into pluripotent stem cells (capable of giving rise to many different cell types).

This extensive preclinical dataset the company has thus far amassed, showing zero evidence of tumor formation at even high dosages (including proof-of-principle PD cohort studies and additional studies focused on safety), combined with direct evidence that injected hpNSCs exhibit a neuroprotectant capacity, as well as an ability to actively recover neurons and address the core motor function symptomatology of PD characterized by dopamine deficiency, is an extremely positive forward indicator to investors. International Stem Cell Corporation has been steamrollering forward with incredible momentum in 2015, ever since the announcement in December of last year that the EU’s Court of Justice ruled in favor of the company’s core technology patent applications, declaring them to be effectively outside the scope of prohibitions on patenting embryonic stem cells, due to a laser-like focus on only ethical derivation of non-embryonic stem cells from unfertilized eggs. Ethically-derived sourcing is a key advantage for International Stem Cell Corporation, especially in the current environment, where a political and ethical debate about stem cell technology is heating up.

Highlights for the company so far this year include solid Q1 results reported in March, showing a 74 percent uptick in gross margins on the strength of a 76 percent increase in operating income from the company’s cosmeceutical and biomedical commercialization. Income growth to $1.62 million in revenue was led by a 5 percent sales jump at the company’s Lifeline Skin Care subsidiary, which specializes in providing rejuvenating skin care products based on nanosphere-enscapsulated proteins extracted from parthenogenetic stem cells. Additionally, the company made waves in the regenerative therapy industry with a talk given in May at the International Society for Cellular Therapy’s (ISCT) annual meeting by the company’s CSO, Ruslan Semechkin, Ph.D., highlighting the potential of hpNSCs for treating PD. The ISCT is the leading global association focused on innovative preclinical and translational cell therapy product development, and Dr. Semechkin’s talk on hpNSC therapy left a lasting impression on key industry participants who attended the Regeneration and Nervous System Repair session at the organization’s 21st annual meeting in Las Vegas.

This move to reverse split the common stock and up-list to a major exchange comes at an auspicious time for International Stem Cell Corporation as the company rockets towards commercialization of a potentially genuine treatment option for PD sufferers and their families. With GlobalData estimates on the PD treatment market running into the $5.3 billion range within the next seven years alone, growing at a compound annual rate of over four percent, International Stem Cell Corporation is poised to become one of the big names in PD treatment, especially considering the company’s ample IP position. The company has made a herculean effort thus far to globally secure its core technology, as well as specific pluripotent human parthenogenetic stem cell (hpSC) lines, with 16 issued patents and 91 pending applications spanning 15 patent families, as well as eight more pending applications across four other patent families related specifically to skin care products. International Stem Cell Corporation has even licensed an additional portfolio of 11 issued and 14 pending patents/applications covering eight patent families in order to further secure its broad-spectrum and rapidly developing hpSC treatment pipeline.

This pipeline includes developing the same hpNSCs used to treat PD, in order to provide stroke patients with the first real solution to this leading cause of adult disability, and the company already has robust preclinical evidence that injection of these highly-pure hpNSCs can be used to actually reverse functional deficits when applied even several weeks after the initial event. This one development would be a major commercial victory for the company and it would also largely establish the concrete viability of its parthenogenetic technology for creating commercial-scale, implant-ready cell banks for the ischemic (roughly 87 percent of cases) stroke treatment and other markets. Not to mention being a game-changer for the roughly 691,650 people every year in the U.S. who suffer from ischemic strokes. People whose only current option is costly, laborious, logistically difficult to implement, and often ineffective cognitive/functional rehabilitation. Commercial success in either PD or ischemic stroke would roundly validate the company’s underlying therapeutic approach for treating other diseases and disorders as well, potentially opening a floodgate for the company and allowing them the kind of financial muscle and industry clout needed to knock down additional targets with hpSC-based therapies.

The company’s hpSC technology is currently being developed for areas such as age-related macular degeneration via parthenogenetically-derived human retinal epithelium (RPE) cell therapy, as well as for corneal blindness and many other eye diseases/disorders via the production of corneal cells and whole corneal tissue. This same technology also shows great promise for treating metabolic (and other types of) liver diseases, such as Crigler-Najjar syndrome (inherited), and the company has already successfully created and characterized stem cell-derived liver cells under its CytoHep program, whose transplantation has been shown to effectively delimit the brain and nerve damage associated with Crigler-Najjar syndrome in preclinical animal models.

If one observes all of these emerging hpSC treatment vectors from a wide angle, it becomes strikingly apparent that we could potentially be treating a whole host of degenerative and other diseases/disorders with 100 percent ethically derived stem cell technology. International Stem Cell Corporation is at the forefront of this industry and the shoring-up of its share structure in anticipation of up-listing to a major exchange, in conjunction with the upcoming landmark clinical trials in PD, for which the company has already comfortably sustained the cost on and manufactured a cell bank of over 2.6 billion high-purity hpNSCs (enough to satisfy all foreseeable clinical trial needs), is an extremely bullish indicator to the investment community about where the company is heading.

Continued success of the company’s already commercialized cosmeceutical and biomedical product operations forms a key backdrop for International Stem Cell Corporation when it comes to funding ongoing clinical and preclinical efforts, further differentiating the company (alongside its strong IP position) from competitors.

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International Stem Cell Corp. (ISCO) Parkinson’s Treatment Just the Tip of the Iceberg for Stem Cell Technology Platform

August 3, 2015

The fact that novel stem cell therapy developer, International Stem Cell (OTCQB: ISCO), is now rapidly advancing from highly successful preclinical studies in Parkinson’s Disease (PD) using human parthenogenetic neural stem cells (hpNSC) derived from its proprietary stem cell technology platform toward a landmark phase 1/2a clinical study clinical study in Australia, has sparked renewed interest in the investment community regarding the company’s technology. After the publication of data on two proof of concept PD studies, demonstrating the safety and functional efficacy of the company’s human parthenogenetic stem cells (hpSCs) – an entirely new class of stem cells created using unfertilized eggs which substantially addresses the problem of cell transplant immune-rejection – the fundamental viability of ISCO’s hpSC approach and the potential for the upcoming clinical trial in PD have caused many in the investment community to dig deeper into ISCO’s dynamic platform.

Given the recent projection by research and consulting firm GlobalData that the PD treatment market alone will continue to grow alongside an ageing global population, running a CAGR of around four percent over the next several years, before hitting around $5.3 billion in 2022, the development of a viable treatment option by ISCO could be a major victory for the company and for patients; a victory which would also broadly legitimize the company’s existing clinical pipeline, while adding fuel to the fire of its existing commercialization. It is important to note that when it comes to PD, leading dopamine agonists like pramipexole and ropinirole, or Neupro/Leganto (rotigotine), work by merely imitating dopamine, stimulating the brain in a similar fashion and thus making up for the dopamine-producing cells that have died due to the onset of PD.

Dopamine agonist regimens do not represent a real treatment and merely mask the underlying disease. While such PD regimens return some percentage of motor and cognitive control to the patient, they are a far cry from the demonstrated ability of ISCO’s transplanted hpNSCs to both actively differentiate into new dopamine-producing neurons and simultaneously act as a neuroprotectant, addressing both the patient’s current symptoms and helping to stop further deterioration. ISCO’s approach is closer to that of regenerative medicine company Neuralstem, Inc. (NYSE: CUR), whose initial therapeutic product, derived from spinal cord neural stem cell lines, has received FDA orphan status for application in ALS, more commonly known as Lou Gehrig’s disease.

In ISCO’s case, the derivation and implementation methodologies are of particular interest, especially given the immune-matching aspects of the technology and its scalability potential, both in terms of producing large quantities of stem cells for transplant and with regards to addressing therapeutic avenues beyond the scope of the company’s current clinical pipeline. As the company moves out of the preclinical stage in its work on PD using hpNSCs, which have also shown significant promise as a legitimate treatment option for actually reversing the functional deficits associated with a stroke, when administered even weeks after the actual event, it makes sense to take a look at ISCO’s already functional commercial operations based on its stem cell platform technology. This is especially true given the company’s ongoing work with hpSC-derived human retinal epithelium (RPE) cells for treating retinal and corneal blindness, as well as its stem cell-derived liver cell (CytoHep) program, which is focused on developing metabolic liver disease therapies.

A solid five percent sales uptick for Q1 this year compared to 2014 reported by the company’s Lifeline Skin Care subsidiary – which leverages the same ethically-derived stem cell platform technology to create an extract for use in skin care products that have demonstrably shown an ability to improve elasticity, firmness, tone and other sought-after qualities – is a solid indicator of the company’s existing ability to generate revenue from its technology, even before commercialization of the clinical pipeline has been realized. With the global facial skin care market on track to hit somewhere in the neighborhood of $40 billion by 2019 (Transparency Market Research), driven in part by the fact that more and more men are beginning to show an increased awareness of and concern for their skin’s health, ISCO’s capacity to bring revolutionary products to market based on far more potent non-embryonic stem cells than the adult stem cells used by many other entrants to this burgeoning segment of the skin care market, has already placed the company in a class all its own.

A full lineup of facial skin care products, including an antioxidant polisher, brightening cleanser and exfoliating preparation, roundly back up Lifeline Skin Care’s eye firming complex and revitalizing moisture serum products, which are made possible by a nanotech encapsulation of the stem cell extract’s key proteins. This unique encapsulation of the proteins in an oily two-layer sphere, allows Lifeline products to penetrate deep into the middle layer of the skin, the dermis, where collagen and elastin (the main structural and elastic peptides that give the skin its youthful qualities) are produced.

Lifeline Skin Care customers rave about the results, expressing most often how much lighter and brighter their skin looks and feels. Given the continued success of the company’s clinical pipeline and the demonstrable efficacy of hpSCs in treating notoriously difficult CNS conditions like PD, it is not hard to understand why Lifeline Skin Care products have become so beloved by consumers. The idea of actually replacing skin proteins with high-potency, nanotech encapsulated, small-molecule and therefore readily absorbed proteins is a significant technological leap beyond what other stem cell-based skin care companies have been doing. Clinical laboratory studies showing a 46 percent increase in elastin, and a 48.5 percent on average increase for the two primary types of collagen when using Lifeline stem cell products, adds readily quantifiable weight to the documented expressions by consumers about how their skin feels brighter, more luminous, and healthier after using the products.

Operating income for ISCO from both aforementioned cosmeceutical commercialization and the company’s ongoing biomedical commercialization, which is executed under the company’s Lifeline Cell Technology subsidiary, was up some 76 percent in Q1 this year compared to 2014. Lifeline Cell Technology has quickly become an industry leader in supplying purified primary human cells and optimized cell culture reagents, and while this market is not as immediately lucrative as skin care, the long-term revenue generation potential as the stem cell industry evolves is considerable in its own right. With the best Q1 financial performance owing to the company’s cosmeceutical division, investors should take note of ISCO’s ability to generate revenues well before its clinical pipeline achieves commercialization, a feat which very few young biotechs can boast of.

Cancer is another huge area where we could see such technology revolutionize the way therapy is handled. Stem-cell transplantation following high-dose chemotherapy for instance, has emerged as an established treatment modality for a variety of hematologic malignancies, such as leukemia, lymphoma, and multiple myeloma. The company’s capacity to produce large volumes of immune-matched stem cells using its proprietary parthenogenetic derivation technology, at its GMP facility in Oceanside, California, is a key strategic and logistical advantage here as well. Even such innovators like clinical-stage biopharma BioLineRx (NASDAQ: BLRX) – which recently announced robust stem-cell mobilization capability with its lead oncology candidate, allowing for harvesting of enough cells needed to transplant from healthy volunteers into patients with hematological malignancies – are notably handicapped by comparison when it comes to cell source logistics.

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International Stem Cell Corp. (ISCO) Prepares to Begin Clinical Study of Novel Parkinson’s Disease Treatment Option

June 29, 2015

Imagine a world where there is no donor organ shortage, victims of spinal cord injuries can walk and weakened hearts are successfully replaced; this is the future of regenerative medicine, as outlined by the National Institute of Health. To obtain the massive promises of this revolutionary treatment option, however, it is necessary to successfully overcome the barriers associated with immune response, which have, to this point, severely hampered the advancement of cell replacement therapies. International Stem Cell Corporation (OTCQB: ISCO), through the continued development of its groundbreaking parthenogenesis stem cell technology, is addressing this limitation, potentially unlocking the door to significant advances in the field of regenerative medicine.

Parthenogenesis utilizes unfertilized human eggs to create pluripotent parthogenetic stem cells (hpSC) that can be immune-matched to millions of people. According to the company’s data, a relatively small number of hpSC lines could provide sufficient immune-matched cells to cover a large percentage of the world’s population, effectively minimizing the effects of autoimmune rejection and allowing for continued research into the massive potential upside of stem cell therapy. Unlike embryonic stem cells, which require the destruction of a human embryo, hpSC treatment also avoids many of the ethical issues commonly associated with stem cell research.

ISCO has identified a collection of potential diseases and conditions that could be effectively treated using its hpSCs, but the company’s leading indication is for the treatment of Parkinson’s disease. According to the National Parkinson Foundation, Parkinson’s disease is the 14th leading cause of death in the United States, and an estimated four to six million people suffer from the condition worldwide. Currently, there is no cure and limited treatment options for the disease, creating a significantly underserved market within the pharmaceutical industry.

“In the first quarter of 2015 we completed all the necessary preclinical studies of our Parkinson’s program and formally submitted our application to begin the first clinical study of this novel approach to treating this debilitating disease in humans,” stated Dr. Andrey Semechkin, Chief Executive Officer of ISCO. “We continue to expect to make significant progress during the rest of 2015 towards our goal of providing a viable treatment option for people with Parkinson’s disease.”

During preclinical studies, ISCO has demonstrated the safety and efficacy of treating Parkinson’s disease symptoms in animals with transplanted human parthenogenetic neural stem cells. Moving forward, the company will seek to begin its Phase I/IIa clinical studies through its wholly-owned subsidiary, Cyto Therapeutics Pty Ltd. For prospective shareholders, ISCO’s continued progression with preclinical and clinical studies makes the company an intriguing investment opportunity in the months to come.

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International Stem Cell Corp. (ISCO) Broad-Spectrum Applicability Of Ethically Derived Stem Cell Tech Underscored By Rapidly Advancing Parkinson’s Therapy

June 3, 2015

Degenerative disorders, which often strike our increasingly elderly populations, like the roughly 10k Baby Boomers in the U.S. hitting their 60s and retiring each day, are on the rise all over the planet, affecting more than 45 million people worldwide. Characterized by nerve cells progressively deteriorating to the point of cell death, a process which leads to a host of maladies ranging from Alzheimer’s and Parkinson’s disease, to ALS (amyotrophic lateral sclerosis) and Huntington’s disease, degenerative disorders currently have few, if any, real medical solutions available for patients.

In China, Europe and Japan, the same population and disease phenomena is occurring. Populations where people are living longer and where increased environmental exposure to various bio-accumulating toxins is causing a continued rise in the volume of a variety of neurological diseases and disorders, for which modern medicine remains largely incapable of providing substantial cures, and in some cases, even palliative treatments. This is why the regenerative medicine technology, based on an entirely new class of ethically manufactured stem cells, which is being aggressively developed toward full commercialization by International Stem Cell Corporation (OTC: ISCO), is so exciting.

Parthenogenesis is not a term most people today are familiar with, but the times they are a-changin’ – and they are changing fast. Degenerative disorders once thought incurable are now within striking distance of being effectively combated through the injection of human parthenogenetic neural stem cells (hpNSCs), which not only have all the best characteristics of other types of stem cell technologies, but lack their drawbacks as well. Thanks to the revolutionary work being done by ISCO with pluripotent stem cells (which that have the ability to mature into several different types of cells), chemically stimulating oocytes through a process where no embryo is ever created or destroyed, the dawn of ethical, high-volume, commercial stem cell technology that could be used to treat a wide variety of diseases, is at hand.

Derived from unfertilized human oocytes, the company’s stem cell lines can be made, via their proprietary process, into HLA (human leukocyte antigen) heterozygous “matched” and therefore histocompatible cells that won’t be rejected by the donor, giving this technology a serious advantage in a field still plagued by donor cell rejection. HLA homozygous hpSCs can also be produced which have been shown to exhibit histocompatibility across massive segments of the global human population, meaning that ISCO’s stem cell bank approach to the space could put the company at the forefront of supplying much-needed, large supplies of compatible donor cells to global markets, just as commercialization of this revolutionary technology dawns worldwide.

The upper limit on therapies involving stem cells is quite extraordinary, as these cells function like an atomized organ or other tissue transplant, repairing existing tissue systems by developing into healthy new cells that replace the damaged ones. In degenerative neurological disorders, this is truly a quantum leap, as no effective means exists to otherwise replace brain and other CNS tissue. The idea of injecting Parkinson’s disease (PD) patients with cultured neural stem cells (hpNSCs) that actually grow into new brain cells is extraordinary, and this same approach can be used to treat other neurological diseases as well, for many of which modern medical science can offer essentially only palliative care.

The current standard of care in PD is with dopamine agonists and drugs like oral levodopa (L-dopa), which has significant dosing issues that often lead to episodes where the symptoms of PD reemerge with a vengeance, particularly in patients who have been on an L-dopa regimen for over five years or more. In fact, 90 percent of young-onset sufferers treated for more than five years with L-dopa experience such episodes. L-dopa, while exhibiting fewer than other antiparkinsonian agents, has numerous adverse effects, including psychiatric ones, as well as the potential for the patient to develop dopamine dysregulation syndrome, and even eventual drug resistance. Needless to say, existing approaches are by no means effective solutions and the advent of an actual therapy for restoring the underlying tissue systems would be a paradigm shift of unprecedented magnitude. A shift whose shockwaves would likely propagate into multiple other degenerative disorders, especially considering the removal of ethical considerations about where the stem cells come from, given ISCO’s parthenogenesis production techniques.

The company’s hpNSCs help to repair the brain in several key ways, like responding to damaged cell signals and releasing anti-inflammatory molecules that help speed the recovery process. Directly addressing inflammation, which is one of the major concomitant symptomatological factors in PD, as well as forming new tissue by developing into new cells, are powerful properties that could rocket hpNSCs to the front of the line in PD therapy. Being able to give someone their life back through the application of this technology could change the way we think about degenerative disorders forever. The idea that we could take cases where a loved one has become effectively disabled – representing not just a serious loss for the individual and economy, but typically creating a significant burden for their families and the healthcare system – and actually restore them to nearly 100 percent functionality, represents one of the most exciting frontiers in biomedicine today.

ISCO’s sizeable preclinical GLP and non-GLP study data on hpNSCs, including brain transplant safety studies conducted in healthy and induced Parkinson’s disease animals, showed that not only were the hpNSC injections well-tolerated, with no sign of tumor or other abnormal growth formation at even high dosages, but that a distinct improvement to motor function resulted. These same studies further showed the neuroprotectant and recovery assistance functionality of hpNSCs, as well as a significant increase in dopamine levels, the primary agent which allows brain cells involved in movement to communicate with one another. National Parkinson Foundation data indicates that even in the roughly 15 percent of patients who develop young-onset Parkinson’s disease before the age of 50, the same loss of some 80 percent of dopamine-producing cells is observed before motor function impairment arises, something which clearly indicates the potential of ISCO’s technology.

ISCO is barreling towards their 1/2a clinical study in Parkinson’s disease over in Australia, which should kick off within the coming handful of months, as the company has already submitted the requisite CTX (Clinical Trial Exemption) application needed to commence this landmark study. The high safety levels of this technology and emerging knowledge of the causes and symptomatology of degenerative disorders, could even lead to developing hpSCs into frontline preventative treatments in patients who are identified as at risk or in the early stages of a given disease.

At any rate, ISCO has their eye on the prize and has already completed manufacturing a large supply of over 2.6 million clinical-grade hpNSCs for the Australia Parkinson’s study, enough to easily handle any foreseeable trial requirements, and further validating their UniStemCell bank approach to the market. Paired up with their proprietary parthenogenesis process for manufacturing cells, a regionalized stem cell bank franchising architecture could be a significant source of future revenues for the company, serving scientists and populations across the country and around the world with an essential stem cell line banking framework. Such a framework, while helping to further validate a growing library of hpSC lines with many people working on and developing them, could also develop into a serious royalty-generating engine fueled by diverse, emergent cellular therapeutics.

ISCO has a strong IP position with numerous patents and filings under their belt too, spanning everything from specific pluripotent hpSC lines and production methods, to cell differentiation and research methods, as well as therapeutic and commercial uses. Like the 16 issued and 91 pending patent applications across 15 different patent families, as well as 8 patents pending across 4 different families, covering their stem cell-based Lifeline Skin Care ( products.

For more information, please visit

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International Stem Cell Corp. (ISCO) Scheduled to Present at International Society for Cellular Therapy Annual Meeting

May 27, 2015

International Stem Cell Corp., a California-based biotechnology company developing novel stem cell based therapies and biomedical products, this morning told investors that it has been chosen to deliver an oral presentation on its preclinical studies in Parkinson’s at the 21st annual meeting of the International Society for Cellular Therapy in Las Vegas. ISCO’s chief scientific officer, Ruslan Semechkin, Ph.D., will discuss the data at the “Regeneration and Nervous System Repair” session at 11:45 a.m. on May 30, 2015 in a presentation entitled “Human Parthenogenetic Derived Neural Stem Cells for the Treatment of Parkinson’s Disease.”

ISCO has built an extensive preclinical dataset from a series of GLP and non-GLP studies on human parthenogenetic neural stem cells (hpNSC). The dataset includes safety studies, where hpNSC were transplanted into the brains of healthy animals, and proof-of-principle studies where the cells were transplanted into animals with induced Parkinson’s disease symptoms. The studies show that hpNSCs are well tolerated with no evidence of tumor formation even at very high doses and have the ability to protect and recover neurons, increase dopamine levels and improve the motor function. The Company has submitted a CTX application to the Australian regulatory authorities and plans to begin the phase 1/2a clinical study in Parkinson’s disease within the next few months.

The International Society for Cellular Therapy (ISCT) is a global association driving the translation of scientific research to deliver innovative cellular therapies to patients. ISCT is one of the only organizations focused on pre-clinical and translational aspects of developing cell therapy products. As such, ISCT helps academic, government and biotech/pharma sectors transform research into practice and product. Over 1200 international delegates including clinicians, scientists and regulatory experts are expected to attend this year’s meeting.

For more information on ISCO and its hpNSCs, visit

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International Stem Cell Corp. (ISCO) Utilizing Revolutionary Technology to Unlock the Power of Regenerative Medicine

May 26, 2015

An aging population is currently highlighting the considerable limitations of the medical industry. According to the Mayo Clinic, treatments are increasingly unable to keep pace with the needs of patients, with clinicians only having access to medications or devices that can manage symptoms. However, advances in developmental and cell biology, immunology and related fields have unlocked huge potential for the industry, and regenerative medicine looks to be the game-changing solution.

Despite its promise, regenerative medicine faces significant hurdles moving forward. In particular, immune rejection of transplanted cells has severely limited the huge potential of stem cell therapy. International Stem Cell Corporation (OTCQB: ISCO), through its powerful new stem cell technology, could be on the cusp of overcoming these limitations, opening the door for major advances in the medical market.

Parthenogenesis, ISCO’s proprietary stem cell development process, has allowed the company to develop a new class of stem cells, known as human parthenogenetic stem cells (hpSCs), which possess the most favorable characteristics of the existing classes. Through this technique, ISCO is able to create cells that are exactly matched or histocompatible with large segments of the human population, limiting the risk of immune rejection during treatment.

ISCO has made noteworthy strides towards the commercialization of its cell therapy treatment this year, capturing the attention of industry experts around the globe.

“In the first quarter of 2015 we completed all the necessary preclinical studies of our Parkinson’s program and formally submitted our application to begin the first clinical study of this novel approach to treating this debilitating disease in humans,” stated Andrey Semechkin, Ph.D., Chief Executive Officer and Co-Chairman of ISCO.

Highlights from the company’s business activity thus far in 2015 include the completion of preclinical studies and submission of an application to begin human trials in Australia, completion of manufacture of a bank of 2.6 billion human cells for use in clinical trials and the approval of a Japanese patent covering parthenogenetic methods of stem cell creation, meaning ISCO now has patent protection in all three major world markets (US, EU and Japan).

“We continue to expect to make significant progress during the rest of 2015 towards our goal of providing a viable treatment option for people with Parkinson’s disease,” continued Semechkin.

According to Florida Hospital, Parkinson’s disease affects up to one million people in the United States, with doctors diagnosing as many as 60,000 new cases each year. Upon completion of clinical trials, the potential market for ISCO’s parthenogenetic cell creation is effectively limitless. As the company continues towards marketization for the treatment of Parkinson’s disease, look for substantial opportunities for growth within the medical industry in the years to come.

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International Stem Cell Corp. (ISCO) Unique Stem Cell Tech’s Immense Therapeutic Potential Continues To Be Demonstrated

May 18, 2015

International Stem Cell Corp., a developer of ethical stem cell therapies (as well as biomedical products) based on their pioneering of an entirely new class of stem cells, hpSCs, or human parthenogenetic stem cells, which offer significant advantages over existing stem cell technologies, continues to see the broad spectrum potential of their technology across the company’s entire therapeutic pipeline.

Parthenogenesis is a form of aesexual reproductive cell division where no fertilization occurs, meaning that no viable embryo is created or destroyed. Derived from unfertilized human eggs (oocytes) and differentiated using a proprietary, patented and chemically-defined process, ISCO’s hpSCs are completely ethical and yet also have superior immune matching (low cell transplant rejection rate) and histocompatability (tissue compatibility) properties compared to existing stem cell technologies. In addition, hpSCs are highly pluripotent, or differentiable into many different cell types, meaning they can be used to treat a broad range of diseases. These novel stem cells are also easily proliferated, meaning large quantities can be grown in the lab and the technology thusly represent an effective, practical solution for developing and executing cost-effective transplantation-based therapies, even for large populations of patients.

Indeed, the fact that ISCO’s hpSC technology allows for derivation of HLA (human leukocyte antigen, the major histocompatibility complex which restricts antigen presentation) homozygous hpSCs, even a relatively limited set of hpSC lines could be used to generate huge quantities of immune-matched cells that would correspond to vast swathes of the human population. This innovative technology captures all the best aspects of other extant stem cell technologies, like adult stem cells, embryonic stem cells (hESC) and induced pluripotent stem cells (iPS), but does not suffer from any of the ethical or logistical limitations. This means that ISCO is essentially the tip of the spear in a therapeutically realistic war against dreaded diseases like Parkinson’s, with real solutions in the offing for ischemic (acute) stroke, as well as metabolic liver diseases (using stem cell-derived liver cells – CytoHep), and the crippling impairment of corneal and retinal blindness (using human retinal epithelium and corneal cells – RPE cells and CytoCor respectively).

With FDA clearance for the company’s hpSC technology already under their belt, as well as a soon to begin Phase 1/2a clinical study in Parkinson’s using their human parthenogenetic neural stem cell technology (ISC-hpNSC), including the already completed production of a 2.6 billion cell stem cell bank that will cover all clinical trial requirements, ISCO is within striking distance of having a viable therapeutic solution to Parkinson’s disease. ISCO’s progress in developing a therapeutically realistic solution to this increasingly prevalent CNS disease no doubt appears as a beacon of hope on the horizon to the millions of people around the world whose lives have been shattered by this disease, which currently impacts the lives of as many as seven million people and takes a heavy toll on their families (not to mention national healthcare systems), due to a progressive loss of nerve cells in the victim’s brain that leads to severe motor and mental impairment.

According to one National Parkinson Foundation study, as many as 9.3 million people worldwide will be living with Parkinson’s disease (PD) by 2030 and estimates for the U.S. alone show that as many as 60,000 new cases crop up each year. Market analysis from last year put the (note that these are typically only marginally effective) 2012 PD therapy market at around $3.56 billion globally ($1.15 billion U.S.) with only 2.18 million cases reported. Conservative estimates forecast that the diagnostics/therapy market will grow to $5.26 billion worldwide ($2.33 billion U.S.) within the next seven years alone, using extrapolated market size estimates on a target of only 2.89 million cases.

The profound utility of ISCO’s ISC-hpNSC technology doesn’t stop at PD either, the same ability of these cells to simultaneously differentiate into dopaminergic neurons, while also expressing brain-protecting neurotrophic factors (neurotrophins are key proteins which help neurons survive and thrive), makes them ideal for treating other CNS disorders and diseases. New results which show ISC-hpNSCs may not only reduce but even reverse the symptoms of neurological dysfunction could prove huge for people who have suffered from a stroke, especially considering that the 795,000 plus strokes which occur each year leave those who manage to survive with zero currently approved treatment options, aside from grueling and generally only partially effective physical rehab.

Peer-reviewed publications showing the superior immunological properties of hpNSCs compared to other neural stem cells is also an extremely promising advantage for ISCO and the company has plans to investigate this abundant potential in further detail via upcoming studies. A presentation of extant data on the potential of hpNSCs, including how they are actually attracted to the site of an injury by naturally-occurring molecular chemistry signals, reducing swelling and forming new brain tissue, is set to take place at an upcoming scientific conference and will be announced in the very near future. For ischemic stroke (which accounts for nearly 90% of all stroke cases), the $1.2 billion diagnosis and therapy market as of 2013 set to hit $1.9 billion in five years (6.3% CAGR), where the immediacy of therapeutic response time is directly proportional to recovery outcomes (success), the value of hpNSC therapy, which has been shown in pre-clinical work to reverse associated functional deficits even several weeks after the stroke, is substantial.

A highly effective therapy for acute stroke that can be applied even weeks after the actual stroke would be a major game changer and could help propel ISCO to the top of the stem cell industry.

Dig deeper into this innovative stem cell therapy developer at

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