Category Archives: Stocks to Watch

OTC Markets Group Announces Proposed Changes to OTCQB Standards; Comment Period Underway

April 20, 2017

OTC Markets Group has announced the publication of proposed amendments to the OTCQB Standards, which are scheduled to go into effect May 18, 2017.

Among these proposed changes, OTC Markets Group proposes the addition of new eligibility criteria for companies not required to be SEC reporting. OTC Markets Group further purposes the refining of various continued eligibility requirements and the reorganization of several sections for improved clarity.

Companies following the Alternative Reporting Standard may now become qualified for the OTCQB and will be required to make public disclosure available through the OTC Disclosure & News Service in accordance with the OTCQX and OTCQB Disclosure Guidelines, which are the same disclosure guidelines used by OTCQX companies. In addition, these Alternate Reporting Companies will have certain corporate governance requirements.

Other proposed changes relate to the timing for removing delinquent filers, revision of due dates for International Reporting filings, annual certification of good standing in the state or jurisdiction of incorporation, and the procedures for removing a company from OTCQB for bid price deficiency.

A comment period is ongoing through May 17, and those with feedback regarding the proposed changes should send their comments and questions to mike@otcmarkets.com.

The proposed rules can be read in their entirety at http://dtn.fm/4EywP

RenovaCare, Inc. (RCAR) Leading Innovation in Wound Care Treatment

April 13, 2017

The global wound care market recently reached revenues of more than $20 billion (http://dtn.fm/W1wjB) at the end of 2016, based on sales at the manufacturer’s level. Specifically, the burn care market is expected to grow at a CAGR of 6.8% from $1.68 billion in 2016 to more than $2.33 billion by the end of 2021 (http://dtn.fm/I6abR). The growth in these markets has been largely attributed to factors such as the rising number of burn accidents, an aging population, and the rise in cardiovascular diseases, diabetes, obesity, and other diseases that can cause skin-related problems.

Currently, wound care ranges from anti-infectives, ulcer wound management, moist dressings, and negative pressure wound therapy to wound closure and even conventional skin grafts. These treatments can be extremely painful, slow-to-heal, and are more likely to face complications along the way. Today, more is being done to help patients suffering from skin problems, some of which include a rise in health care expenditure, more government initiatives, an increase in the number of emergency centers and burn units, and a growing understanding of the various treatment options.

In addition, more innovative forms of treatment are slowly being introduced. RenovaCare, Inc. (OTCQB: RCAR), a development stage biotechnology company focused on acquiring, researching, developing, and commercializing first-of-their-kind self-donated stem cell therapies for the regeneration of human organs, is in the process of developing a product that targets issues relating to the human body’s largest organ, the skin.

The company’s CellMist™ system uses a patient’s own stem cells and is applied onto wounds and burns using its SkinGun™. The technology is able to regrow the skin across wounds by spreading numerous regenerative islands over the affected area, rather than the wound healing from the outside in. Although still part of an experimental setting, the system has been tested on patients such as Matt Uram, a victim of a fire-related accident during a July fourth celebration, who, within three days witnessed incredible results, with burns almost completely healed and no risk of infection or scarring (http://dtn.fm/uXAR5).

RenovaCare believes the SkinGun™ could replace today’s standards of care, decreasing the need for patients to go through the process of having complicated skin grafts, mesh skin grafts, and other forms of painful treatment.

The company is aiming to get the SkinGun™ FDA-approved in the near future, and research is already underway at RenovaCare to enable the treatment of third degree burns, which are more complex in nature and often come with damage to the muscles and tissue below the skin.

For more information, visit www.RenovaCareInc.com

Marina Biotech, Inc. (MRNA) Sets Further Development of Drug Candidates IT-102 and IT-103, Signs Windlas Healthcare Manufacturing Agreement

April 7, 2017

Marina Biotech Inc. (OTCQB: MRNA) filed a 10K with the SEC on April 5, 2017, for its year ended December 31, 2016. The late stage biopharmaceutical company summarized its achievements in 2016 and provided an outlook into its 2017 performance, including its planned clinical trials in 2018. Marina Biotech specializes in creating and commercializing innovative therapies for treatments of cancer, hypertension, and arthritis.

The firm plans to move by the first quarter of 2018 into a phase 3 clinical study of its drug candidate, IT-102, a fixed dose combination (FDC) bi-layer tablet, said Joseph Ramelli, chief executive officer of Marina Biotech. It recently signed an agreement for Windlas Healthcare Limited to manufacture the tablet, positioning Marina Biotech for the Phase 3 study. That India-based firm has facilities that are approved by the Food & Drug Administration (FDA) in the U.S., as well as the European Union Good Manufacturing Practices (EU cGMP).

The company also reported:

  • Marina Biotech expanded its unsecured credit line from its chairman, Dr. Vuong Trieu, on April 4, 2017, for an additional $500,000. The initial line was for $540,000 secured last November. The company had drawn down $250,000 of that by December 31, 2016. The company also secured another line of credit from Autotelic, Inc., for the commercialization of IT-102 and IT-103.
  • The company announced that it has completed its merger with IThena Pharma, enabling it to advance its development of combination tablets for arthritis, pain, cancer and hypertension. The transaction with IThena Pharma has put in motion a new pipeline by Marina Biotech that advances its development of combination therapies.
  • Marina Biotech announced the results of new preclinical and clinical data for its drug candidates IT-102 and IT-103. These results support the further development of both for the treatment of hypertension/pain, Ramelli said. Among these results was the indication that IT-102 and IT-103 could serve as unique anticancer agents.
  • In February of 2017 the company entered into a licensing agreement with LipoMedics, under which Marina Biotech could receive up to $90 million in milestone payments which are success based. Under that agreement, Marina Biotech gave a license to LipoMedics for its SMARTICLES platform for the delivery of nanoparticles, including small molecules.

For more information, visit www.MarinaBio.com

AzurRx BioPharma, Inc. (NASDAQ: AZRX) Overcoming Current Exocrine Pancreatic Insufficiency Treatment Limitations

March 31, 2017

Exocrine Pancreatic Insufficiency, or EPI, is a problem in a person’s digestive system. Simply put, EPI is when the pancreas cannot produce enough of the enzymes that the body requires to break down and absorb nutrients. Unfortunately, this means that the body is unable to absorb the right fats and nutrients, often leading to weight loss.

There are a number of causes for EPI, such as inflammation of the pancreas; effects from surgery on the pancreas, intestines, or stomach; or even an inherited disease such as cystic fibrosis, Shwachman-Diamond syndrome, Crohn’s Disease, diabetes, or celiac disease. Symptoms do vary, but normally the patient will feel a pain or tenderness in the abdomen, problems with bowel movements, flatulence, and a feeling of being full.

Today, there has been a rise in the number of people with EPI, and this has been largely attributed to an increase in the number of patients diagnosed with diabetes and cystic fibrosis (CF). According to an article from PR Newswire (http://dtn.fm/uyF9L), there are approximately 70,000 people living with cystic fibrosis worldwide, with 1,000 new cases diagnosed each year. In addition, 50% of children with CF suffer from EPI from the moment they are born.

According to TransparencyMarketReserarch.com (http://dtn.fm/0tvSc), the EPI market is growing at an astronomical rate, and this is not expected to slow, since the number of patients diagnosed with diabetes is expected to grow to approximately 366 million by the end of 2030. PR Newswire reported an anticipated expansion of the market at a CAGR of over 8% between 2015 and 2023, allowing it to reach just under $3 billion.

Unfortunately, despite the expected market growth, current EPI treatments have a number of limitations. Aside from a healthy diet, the current treatment for EPI is Pancreatic Enzyme Replacement Therapy (PERT), but not only are these treatments not very effective, they also show a lack of stability in an acidic environment and carry a high pill burden, which can be highly inconvenient for patients.

Luckily, AzurRx BioPharma, Inc. (NASDAQ: AZRX), a development stage biopharmaceutical company focused on creating treatments for patients suffering from gastrointestinal diseases such as EPI, is currently in Phase IIa of the development of MS1819 lipase, a non-systemic, yeast-derived recombinant enzyme.

This orally-administered capsule is not only showing significant potential for the treatment of EPI in patients with chronic pancreatitis and cystic fibrosis; it is also demonstrating activity in long chain fats and stability in protease and bile salt environments. MS1819 lipase could give patients suffering from EPI the chance to reduce their pill burden from 25 to 40 pills a day to as little as five to eight.

For more information, visit the company’s website at www.AzurRx.com

MeetMe, Inc. (NASDAQ: MEET) Closes on 9.2 Million Share Public Offering, Sees 2Q2017 Target on Acquisition of if(we)

March 29, 2017

MeetMe, Inc. (NASDAQ: MEET) has closed on its public offering of 9.2 million shares of common stock at $5 per share. This is inclusive of the full option by underwriters for 1.2 million additional shares of common stock. Net proceeds will be used by the company for general corporate purposes and to potentially fund MeetMe’s pending acquisition of “if(we)”, a San Francisco-based social and mobile technology company, as well as other future takeovers.

MeetMe is a social network for meeting new people in the U.S. Some 80% of its one million daily user traffic comes from mobile devices, such as iPhones, iPads, and Android devices. It is becoming a gathering place for mobile users, the company said. It generates revenue from advertising, subscriptions, and virtual currency.

Targeted to close in 2Q2017, the “if(we)” acquisition would be made for $60 million in cash, and that company is anticipated to generate at least $9 million of adjusted EBITDA and be accretive to earnings in the first 12 months after closing, MeetMe noted in a news release.

“if(we)” had revenues of $44 million in 2016 and is the operator of TAGGED and Hi5, branded apps which enable people to meet and chat with others. The site features 10.4 million mobile chats daily, and 18,000 mobile app users are added each day. “if(we)” is available in 100 countries and 15 languages.

MeetMe said in its corporate presentation on the acquisition (http://dtn.fm/J4gAA) that the transaction is expected to generate cross-promotional opportunities. It added that there is a less than 5% overlap in user bases, and the two companies together can lower technology costs by standardizing products. Also, by utilizing MeetMe’s best practices, the company expects a convergence of certain key metrics, such as daily chats.

Funding for the acquisition will come from MeetMe’s cash on hand, cash from operations, and a new $30 million loan from J.P. Morgan. The combined company could generate revenues of $150 million annually and an EBITDA of $50 million, per MeetMe’s presentation materials.

For more information, visit www.MeetMeCorp.com

Greenkraft, Inc. (GKIT) Making Itself Available to the Entirety of the United States

March 28, 2017

Most vehicles across the United States are powered by either gasoline or diesel, but this is changing. Sales of cars, especially fleet vehicles, that operate on alternative fuels are growing, and, according to the U.S. Department Of Energy, natural gas now powers more than 150,000 vehicles across the country and over 15 million vehicles worldwide (http://dtn.fm/LF8Zg).

Because natural gas as a transportation fuel is widely distributed, domestically available, more cost efficient, and better for the environment, these new vehicles are expected to become increasingly popular for the foreseeable future, and, thanks to Greenkraft, Inc. (OTCQB: GKIT), they will soon be making their way across the U.S.

Greenkraft, a company that manufactures and markets alternative fuel systems to convert petrol-based vehicles and engines to function on natural gas and propane fuels, offers a variety of trucks and engines to suit various modern-day business needs. In fact, all of its products are built to suit companies in the food, electric, construction, and landscaping markets, among others.

Greenkraft prides itself on offering fuel efficient trucks that not only save businesses money, but are also better for the environment. These vehicles meet EPA and CARB emission standards and use only alternative fuels for power. To top it off, the company works closely with the government to encourage businesses to switch to more eco-friendly automobiles through tax incentives and rebates.

Most recently, Greenkraft announced that it will be launching a widespread national marketing campaign to include printed advertisements, trade shows, and targeted campaigns that will showcase its trucks and engines to the majority of the U.S. market. In addition to bringing in new customers, GKIT wants to educate companies about the positive environmental impact they could have by changing their transportation methods.

A month prior to this press release, the company announced that, due to increased demand for its products, it will be expanding to a bigger factory in 2017 and introduce new, larger-sized trucks in weights of 26,000 and 33,000 pounds, respectively. The combination of this new nationwide marketing campaign and its plans to expand to a bigger factory will enable GKIT to meet customer needs while having a serious positive impact on the environment.

For more information, visit www.GreenkraftInc.com

Heat Biologics (NASDAQ: HTBX) at the Vanguard of a Paradigm Shift in Cancer Treatment

March 24, 2017

The human body is elegantly designed to heal itself, utilizing the immune system as its defense against various pathogens. Triggered by immune response signals, the immune system attacks and kills organisms and substances that invade body systems and cause disease. However, the immune system sometimes needs help in identifying and killing some invaders.

Cancer presents a complex and perplexing problem for effective immune system response, because it finds ways to hide from the immune system or block the immune system’s ability to battle against the disease. An important part of the immune system is its ability to differentiate between normal cells in the body and invaders. This differentiation allows the immune system to attack the invading cells while leaving normal cells alone. To achieve this, the immune system uses molecules on certain immune cells that need to be activated or inactivated to trigger an immune response. However, cancer cells can sometimes use these checkpoints to deceive the immune system and avoid being attacked. Newly developed drugs, known as checkpoint inhibitors, have shown some success in cancer treatments. However, a combination of checkpoint inhibitors and specific T cell-stimulating therapeutic vaccines indicates a much higher degree of efficacy.

Heat Biologics (NASDAQ: HTBX) is at the vanguard of this shift in cancer treatments, developing novel therapeutic vaccines to activate the immune system against a wide range of cancers. When antigens enter the body, they stimulate the immune system to produce antibodies in response to these foreign substances. Heat Biologics exploits this natural process to elicit a powerful immune response against the disease target. The company’s therapeutic vaccines are based on heat shock protein gp-96, a protein that activates the immune system when cells die. This protein is attached to the cell by what’s called a KDEL leash. Heat Biologic’s vaccines remove this leash and cause cells to continuously secrete gp96 and its chaperoned antigens to activate the immune system.

Heat Biologics recently announced the latest results of its ongoing phase 2 clinical trial in combination with Bristol-Myers Squibb’s checkpoint inhibitor. Researchers reported a strong correlation between T cell activation, tumor reductions, and increased overall survival in the patients evaluated. Patients with a sustained immune response also exhibited substantial tumor reductions. It appears the combination of Heat Biologics’ vaccine and checkpoint inhibitors may become an attractive therapeutic approach treating cancers.

For more information, please visit www.HeatBio.com

Cannabis Businesses Represent Diverse Opportunities of Booming Market

March 21, 2017

The U.S. medical and recreational marijuana industry continues to expand. Even though the debate over medical efficacy and the concerns over recreational marijuana use continue to cause political and social divisions within the country, the investment community is moving rapidly from benign interest to embracing the marijuana industry as a significant investment opportunity.

At the recent 29th annual ROTH conference, an investment conclave attracting global financial gurus, even traditionally conservative industries like private equity groups took serious consideration of the marijuana market opportunities. The opening conference panel discussion centered on the medical uses for marijuana and emphasized the upside potential in the burgeoning marijuana market that is already underway.

In attendance at the conference and presenting to fund managers and investment advisors was GrowGeneration Corporation (OTC: GRWG). GrowGeneration currently owns and operates 12 specialty retail hydroponic and organic gardening stores with locations in Colorado, Nevada and California. With the company’s focus on owning and operating branded stores in all of the major legalized cannabis states, it currently sells thousands of products to facilitate the cultivation of marijuana for commercial and home growers.

GrowGeneration went public last year and is fast moving toward its objective of becoming the first company in its vertical on the NASDAQ stock exchange. Interviewed at the conference, Darren Lampert, CEO of the company, stated in part, “Investors are seeking out investments in the cannabis industry and are hoping to profit from the fastest growing new market in the USA in some time. GrowGeneration benefits from all sides as more growers come to us for their equipment and nutrients, which is why we were able to grow as exponentially as we have without directly touching the end product.” By supplying a vast array of specialty retail hydroponic equipment, lighting, and organic nutrients and soils to horticulturalists and marijuana cultivators, GrowGeneration is focused on reaping rewards from the explosive growth of this fledgling industry.

Already one of the nation’s largest specialty retail hydroponic and organic gardening store chains, GrowGeneration acquired all of the assets of Sonoma Hydro last month creating a $2.5 million northern California retail distribution center. Northern California’s “Emerald Triangle,” home to a large concentration of cannabis cultivators, is a significant growth opportu­nity for the company, with the market projected to grow at a compounded annual rate of 18.5%, reaching $6.5 billion by 2020.

Further validation of the huge potential of this market can be found in GrowGeneration’s press release last week. The company announced that Merida Capital Partners, a cannabis infrastructure fund, has provided GrowGeneration $1.65 million in equity financing. When factoring in warrant exercises, funding will total $3.92 million in capital. Merida Capital Partners priced callable warrants at $4.12 or higher, an obvious indication of its belief in the company.

Whether one agrees with the surge in the cannabis industry or not, there’s no denying the wizards of Wall Street are believers. Now may be the time for individual investors to participate and potentially profit from one of the fastest growing new markets in America, which is occupied by a number of other innovators such as: MyDx, Inc. (OTCQB: MYDX), which offers CannaDX, a unique device that allows anyone to directly test cannabis products for THC, CBD, and CBN potency; Innovative Industrial Properties, Inc. (NYSE: IIPR), which focuses on an entirely different aspect of the industry, helping licensed MMJ growers meet capital needs by purchasing their grow-land and leasing it back to them; Terra Tech Corp. (OTCQX: TRTC), which designs and sells its own specialized hydroponic and associated equipment for indoor growing, in addition to the retail selling of cannabis products; and Aphria, Inc. (OTCQB: APHQF), which produces and sells a variety of “100% Greenhouse Grown” cannabis products throughout Canada.

Neogen Corp. (NEOG) Keeping People and Animals Safe with Traditional Lab Methods

March 17, 2017

Foodborne illnesses are more common than people believe. These infections are not only common but costly, and also very preventable. Every year, one in six Americans get sick from consuming the wrong food or drink. Unfortunately, because there are so many different microbes and pathogens that can cause disease, there are also many different types of infections.

With more than 250 different foodborne diseases now described, each has its own set of symptoms, and some have lethal results. Normally, a person contaminated will suffer from temporary nausea, vomiting, abdominal cramps, or diarrhea, but because of the variety of bacteria, viruses, and parasites found in certain foods, these contaminated foods can also cause long-term health problems, or even death.

The hardest aspect of food safety is controlling the various times at which food can get contaminated. The food supply process today is extremely complicated and comes with its own set of very strict rules. However, there are many opportunities for food contamination to take place. These include on-farm production, harvesting or slaughtering, processing, storage, transport, and distribution.

Neogen Corp. (NASDAQ: NEOG) a company that develops, manufactures, and markets various products and services relating to food and animal safety, has, for its mission, to be the leading food and animal safety company, keeping people and animals safe throughout the food making and marketing process.

The company keeps food and animals safe from inside the farm gate through to the moment it arrives on people’s plates. From intervention products to diagnostic products, NEOG provides test kits, instrument systems, consumables, culture media, software, and services for the food safety market. It also provides a complete line of veterinary diagnostics, instruments, pharmaceuticals, nutritional supplements, disinfectants, and rodenticides for the safety of animals.

Although many companies today have replaced traditional lab methods with more modern test formats, Neogen still believes in the time-tested methods discovered and developed in the mid-1800’s. The company serves this market with its Acumedia dehydrated culture media lines and competes in each segment of the Food Safety market. It now has some of the world’s top food and animal producers and processors as clients, and offers more than 400 products to the market.

For more information, visit the company’s website at www.Neogen.com

UGE International Ltd. (UGEIF) Guided by Corporate Motto of “Be Green, Be Great, Have Fun”

UGE International Ltd. (OTCQB: UGEIF) delivers distributed renewable energy solutions to commercial and industrial customers around the world. The company provides full-service renewable energy solutions using industry-leading technology and delivers affordable, sustainable, and reliable energy to business enterprises.

The company has four lines of business that seamlessly dovetail to deliver end-to-end renewable energy solutions that are easy to manage and don’t interfere with customer business continuity. The company’s business lines include: consulting and project management, engineering and design, development, and turn-key EPC (engineering, procurement and construction).

UGE provides consulting and project management services in all aspects of solar photovoltaic services such as site feasibility studies, financial analysis of the project, local electric authority submittals and approvals, building permits, power and energy production verification, equipment procurement and more.

The company’s engineering and design line of business sets high standards for comprehensive detail and design of renewable energy projects and includes, among others, optimal solar array layout, complex grid interconnection design, ground-mount and rooftop system design and electrical, civil, geotechnical and structural design.

Under the company’s development line of business, UGE can finance and develop complete ground and rooftop photovoltaic solutions. The company has relationships with energy cooperatives and municipalities and facilitates rooftop and ground-mount site procurement. UGE has technical expertise with knowledge and experience in the development process and has access to capital and take-out partners to address financial concerns.

The company’s turn-key EPC line of business provides complete services to manage project execution from start to completion, which includes full turn-key services such as engineering and design, equipment evaluation and procurement, construction and contractor management, system commissioning and system monitoring.

UGE International focuses on multiple markets in the United States, Canada, Panama, China and the Philippines. The company was named among the Top Solar Contractors by Solar Power World, and it has over 330 MW of solar energy experience. UGE’s dedication to excellence is reflected in its motto, “Be Green, Be Great, Have Fun,” and has catapulted the company toward becoming a world leader in distributed renewable energy.

For more information, please visit http://www.ugei.com

ImageWare Systems, Inc. (IWSY) Sets March 30 Conference Call, Receives Frost & Sullivan Award for New Product Innovation

ImageWare Systems, Inc. (OTCQB: IWSY) has set a March 30, 2017, conference call (http://dtn.fm/4j16M) for a corporate update on its fourth quarter and year ended December 31, 2016. Results for those periods will be released prior to the call, which is scheduled for 5 p.m. (ET). Hosting the call will be Jim Miller, ImageWare chairman and CEO, and Wayne Wetherell, CFO.

The San Diego-based company designs cloud-based and mobile multi-modal biometric identity management solutions, including biometric authentication technology. Its biometrics are next generation and are interactive and scalable cloud-based solutions. The company offers multi-factor authentication for desktop devices, smartphones, and mobile clients. Its products include authentication by face, voice, fingerprint, eye, DNA, and more. It also develops access control tools.

ImageWare recently received the 2017 North American Frost & Sullivan Award for New Product Innovation. The award was presented in recognition of its GoVerifyID Enterprise Suite, which provides multi-modal biometric user identification as an end-to-end turnkey solution.

“This mobile/cloud SaaS (software as a service) offering is the industry’s first multi-modal biometric user authentication solution that allows customers to strengthen the security of their passwords or two-factor authentication using biometrics. Rather than typing a password, end users can speak a passphrase, swipe their fingerprints, or even take ‘selfies’ to gain access,” Frost & Sullivan noted in a news release.

It also cited ImageWare’s GoVerifyID Enterprise Suite, which is Windows Server certified. It noted that this product is device-agnostic and allows user authentication via the cloud. Additionally, Frost & Sullivan said, ImageWare has shown speed in response to market needs in the fast changing world of identity management.

For more information, refer to www.IWSInc.com

Vertex Energy, Inc. (NASDAQ: VTNR) Focused on Used Oil Recycling

The foundation of Vertex Energy, Inc. (NASDAQ: VTNR) was laid by the employment of a 16-year-old Alabama teenager, with the result being that a multi-faceted environmental services company was eventually built upon the endeavors of that teenager. Roughly 30 years ago, Benjamin Cowart, now the CEO and chairman of Vertex, began work at his brother’s used oil collection business in Alabama. After 15 years of working, learning, and helping to build a successful business, he ventured out on his own and formed Vertex in 2001. Vertex Energy now collects and recycles used motor oil and other petroleum by-products, off-specification commercial chemicals, and multiple other industrial waste streams.

Vertex purchases used oil, industrial waste, and chemical products from a developed network of local and regional suppliers, known as street collection, and focuses resources on recycling a portion of its collected used motor oil and other petroleum products. Vertex also sells used petroleum products as feedstock to other re-refineries and fuel blenders or as replacement fuel for use in industrial burners.

The company’s Black Oil division operates across the entire used motor oil recycling spectrum. From used oil and petroleum product collection and aggregation, the company transports, stores, refines, and sells re-refined products to end users. The company’s Refining and Marketing division aggregates feedstock, re-refines it, and then sells the various products. The company’s Recovery division delivers solutions for the recovery and management of hydrocarbon streams.

Expanding feedstock, Vertex Energy has acquired several other used oil collection routes. At oil’s peak, Vertex Energy was paying local generators $1.00 per gallon for used motor oil, but, with the collapse in oil prices, Vertex was able to move from paying for used oil to charging for collection. Vertex has been challenged like others in the oil business but has targeted 2017 as the year for its collection acquisitions to play out.

Headquartered in Houston, Texas, with facilities in Louisiana and Ohio, and offices in Illinois and Georgia, Vertex Energy has come a long way from that Alabama teenager.

For more information, please visit www.VertexEnergy.com

Extreme Networks, Inc. (NASDAQ: EXTR) Enters Asset Purchase Agreement for Avaya Networking, Subject To Bankruptcy Court Approval

March 15, 2017

Extreme Networks, Inc. (NASDAQ: EXTR) has entered into an asset purchase agreement for Avaya Networking, Inc. totaling $100 million, subject to adjustments. In January 2017, Avaya and certain of its subsidiaries filed for Chapter 11 bankruptcy in the Southern District of New York. Extreme Networks’ offer is subject to court approval. The company defined its offer in an 8K SEC filing on March 7, 2017 (http://dtn.fm/t3joR).

Extreme Networks, Inc. is a networking company based in San Francisco. It designs, builds and installs ethernet computer network products. It is a software-driven company that enables IT departments of clients to build stronger relationships with customers, employees, and partners. The company maintains more than 20,000 customers in some 80 countries. A key asset for Avaya is its award-winning fabric switching technology. Switching fabric typically includes data buffers.

Extreme Networks’ asset purchase agreement comes as a result of potential synergies with Avaya Networking, Inc., as identified by the EXTR management team. Extreme Networks believes it offers complementary products between the two businesses across the company’s vertical markets. For Extreme Networks’ clients, the deal, if court approved, would offer technology for edge switching environments in addition to secure access to Avaya’s data center. For Avaya, selling its networking business is seen by its management as a positive move, enabling it to focus on its unified communications core.

Extreme Networks believes that, if the offer is consummated, it could result in $200 million of added revenues annually. The acquisition is expected to be accretive to its own earnings and cash flow beginning in fiscal 2018. Extreme Networks intends to update its quarterly guidance and revenue if the acquisition is approved.

The tentative agreement remains subject to better offers, as Avaya plans to make a motion to the court to initiate a bidding and public auction process. On execution of the purchase agreement, Extreme Networks placed $10 million in escrow. Pending approval, these funds will be applied to the purchase of Avaya’s assets, but not to any of the firm’s liabilities. If the deal is not approved, Extreme Networks may be entitled to court-approved termination fees.

For more information, visit www.ExtremeNetworks.com

BioVie, Inc. (BIVI) Develops New Approaches to Devastating Liver Diseases

It’s estimated that over one million Americans and millions more worldwide suffer from liver cirrhosis. Globally, it accounted for over 1.2 million deaths in 2013, and it’s the 12th leading cause of death by disease in the United States, where 27,000 Americans die each year from the disease. Worldwide, 57 percent of cirrhosis is attributable to either hepatitis C or hepatitis B. Long-term alcohol abuse accounts for about 20 percent of cirrhosis-related deaths globally, while, in the United States, 40 percent of cirrhosis-related deaths are caused by alcohol abuse. Each of these disease drivers triggers the replacement of normal liver tissue with damaged scar tissue, which impedes blood flow and the liver’s ability to clean and purify blood.

Liver cirrhosis has multiple potential causes and often more than one of them can be found in the same patient. The disease’s most common complication is ascites, which is the abnormal accumulation of fluid in the abdomen, often accompanied by kidney dysfunction. This life-threatening condition causes severe suffering, frequent infections, and multiple complications that can lead to a painful death.

Currently, no approved medications to treat ascites are available. Diet change and drugs used off-label can provide some initial symptomatic relief, but, as the disease worsens, response rates fall. About 40 percent of patients die painfully within two years of diagnosis. The treatment costs for liver cirrhosis, including ascites and other complications, are deemed to be in excess of $4 billion annually in the U.S. alone.

The unquestioned human and financial toll of liver cirrhosis on patients, families, and society has created a real need for treatment solutions. One development stage biotechnology company, BioVie, Inc. (OTCQB: BIVI), is pioneering just such innovative treatment solutions. BioVie actively pursues the discovery, development, and commercialization of innovative drug therapies for liver diseases. Just four months ago, BioVie submitted an Investigational New Drug (IND) application for its initial drug candidate, BIV201, to the U.S. Food and Drug Administration (FDA). This new drug has the potential to become the first drug approved by the FDA to treat ascites due to chronic liver cirrhosis and could become the breakthrough treatment so desperately needed around the world.

For more information, visit www.BioVieInc.com

PowerBuoy® from Ocean Power Technologies (NASDAQ: OPTT) Provides the Power for Marine Installations

March 13, 2017

John F. Kennedy got it right when he said that we go to the seaside to gaze at the place we came from. The oceans may no longer be our home, but we still depend indispensably on them. Oceans cover about 70 percent of the Earth’s surface, and their vast masses of phytoplankton provide around half the oxygen we breathe. Ocean Power Technologies (NASDAQ: OPTT) is a company focused on preserving and developing our heritage to the seas. It provides marine-based solutions to the oceanographic, oil and gas, and security and defense industries. Its PowerBuoy® technology uses the motion of the waves to generate power, providing reliable, cost effective, clean power to marine installations.

The PowerBuoy PB3 is a power and communications platform for remote offshore applications. It combines a number of patented technologies in hydrodynamics, electronics, power conversion, energy storage, and computer control systems to maximize the extraction and conversion of energy from ocean waves. The result is a leading edge, ocean-tested, proprietary power conversion and management system that turns wave power into reliable, clean, and environmentally beneficial electricity for offshore applications.

The PB3 is a floating system that extends 10 feet above the waterline and 30 feet down into the water. It is anchored to the sea floor and can be employed in depths of up to 3,000 feet. The electricity it generates can be stored on-board or used for nearby applications.

Our economic wellbeing is inextricably linked to the oceans. One out of every six U.S. jobs is marine-related, and about one-third of U.S. GDP originates in coastal areas. But access to cost-effective power is a constant challenge to offshore installations that need autonomous power and real-time communications.

Consequently, OPTT’s proprietary PowerBuoy® technology has a huge addressable market. Oceanographic applications that study the biology and chemistry of the seas present a potential market of $2 billion; the oil and gas industry is another market worth $2.5 billion; the defense and security industries offer a $3.5 billion market opportunity and communications are worth $0.5 billion, bringing the total addressable market to $8.5 billion.

The PowerBuoy® technology is a more reliable solution than either wind or solar installations, which are subject to the vagaries of the weather. But as some wit opined, you can’t stop the waves; you can only learn to surf. The PowerBuoy® technology, which can include a modular high-capacity storage system, offers a clean and reliable source of renewable and cost-effective energy.

In July 2016, OPTT announced the deployment of its commercial design of the PB3 PowerBuoy® approximately four miles off the coast of New Jersey, and, in September 2016, the company disclosed that it had signed a contract with the U.S. Department of Defense to conduct the design of a new mass-spring oscillating PowerBuoy for mission critical sensors. The company recently also successfully completed the review by Mitsui Engineering and Shipbuilding (MES) of Japan. This opens the way for MES’ planned lease of a APB350 PowerBuoy for a project off the coast of Kozu Island in Japan. Ocean Power Technologies is definitely riding the waves.

The company is a leader in the development and commercialization of wave-energy technology that converts ocean wave energy into electricity. Based in New Jersey, OPTT is staffed by about 30 people, of which about 20 are engineers with graduate degrees. Its intellectual property portfolio is robust, including over 65 patents awarded or pending. OPTT’s current market cap is about $16 million.

For more information, visit www.OceanPowerTechnologies.com

The Diversified Domain of Easton Pharmaceuticals, Inc. (EAPH)

March 10, 2017

Drug development. Medical marijuana. Female diagnostics and treatments. These high-growth industries and sectors are the focal points of Easton Pharmaceuticals, Inc.’s (OTC: EAPH) operations. A diversified and specialty company based in Canada, Easton’s operation spans multiple pharmaceutical sectors and other emergent industries, including the medical marijuana market.

In its day-to-day operations, the company balances three mission goals:

  1. It develops and acquires drugs, diagnostics and treatment products that build shareholder value.
  2. It delivers safe, effective and proven products that improve the health and well-being of men and women across global jurisdictions.
  3. It builds and capitalizes on fast-growing and promising industries and sectors defined by products like medical marijuana, vaporizers, e-liquids and other items.

Within the pharmaceutical sector, Easton designs, develops and markets a variety of topical drugs and therapeutic health care products. It formerly developed and owned a wound-healing drug approved the U.S. Food and Drug Administration. Presently, however, its portfolio includes products in various stages of development and approval, from topically-delivered drugs that treat cancer to therapeutic products that treat varied conditions. For one, Easton is the midst of developing XILIVE, an early stage cancer drug. For another, it is growing its product portfolio, which currently includes: Kenestrin Gel used for arthritic pain and pain in the back, elbows, knees, shoulders and wrist; Nauseasol, a motion sickness gel; Skin Renou HA, an anti-aging wrinkle cream using hyaluronic acid, which keeps the skin smooth; Viorra, a hormone-free, non-toxic, and topical gel that improves a woman’s sexual functioning; and a female sexual arousal disorder drug.

Another key product in Easton’s portfolio is AL-Sense (AmnioSense), an amniotic fluid diagnostic leak test. Through a strategic partnership, Easton and another company, BMV Medica SA de C.V., own the exclusive distribution rights for AL-Sense (AmnioSense) in Mexico and Latin America. AL-Sense (AmnioSense) is a patented women’s diagnostic product that has been approved in Europe and is already being sold in the United Kingdom. With the birth rate in Latin America estimated at three times that of North America and most of Europe, it opens up a vast market for the Easton / BMV partnership, one with a population greater than 200 million people. The higher birthrate in the region and other factors also portend a faster rate of sale for pharmaceutical and diagnostic products, approximately five times the rate of North American and European sales.

For more information, visit www.EastonPharmaceuticalsInc.com

Vertex Energy, Inc. (NASDAQ: VTNR) Taking Strides toward Conserving US Environmental and Energy Resources

Vertex Energy, Inc. (NASDAQ: VTNR), an environmental services company that focuses on aggregating, processing, and recycling industrial waste systems and off-specification commercial chemical products, is taking strides toward conserving the environmental and energy resources of the United States by operating in three key divisions: Black Oil, Refining & Marketing, and Recovery.

The Black Oil Division collects, aggregates, processes, and then sells used motor oil (UMO) and finished products, while the Refining & Marketing Division aggregates and manages the refining of off-specification petroleum and chemical products. Lastly, the Recovery Division provides hydrocarbon stream recovery and management solutions, industrial dismantling and demolition, and decommissioning services.

Vertex Energy also uses a variety of refining technologies. These include base oil, VGO, and TCEP, with refineries located in Columbus, Ohio; Marrero, Louisiana; and four other terminals. These aggregate UMO collected from across eight to 10 major metropolitan areas.

The company is made up of third-party aggregation systems with approximately 50 collectors, 43 trucks operating as collectors, a nationwide processing capacity of over 115 million gallons, and in-depth market knowledge that enables its sales model to foster strong, localized relationships. VTNR now has 2 terminals for aggregation in Houston and Mobile, and it has developed and patented a unique UMO processing technology.

Although Vertex Energy still has a presence across the country, taking on 23 percent of total UMO refining capacity in North America, it now operates in strategic regional hubs, allowing it to optimize its transportation costs. The company has two refining facilities in Texas, two in Louisiana, and one in Ohio. All of these have a diversification of product mix, with one in Baytown strategically located to capitalize on the export market created by Gulf refiners, and one which is capable of low-capex conversion, allowing it to produce base oil.

Most recently, Vertex announced its fourth quarter and end-of-year financial results for 2016. For the three months ended December 31, 2016, the company reported revenues of over $31 million, a growth of nearly 50 percent compared to the same period of 2015. VTNR’s gross profits came in at over $5 million, more than 1,000 percent higher than the previous year, with a gross profit margin of 17 percent. Additionally, the company’s SG&A expenses decreased more than 30 percent compared to the same period of the previous year, and per-barrel margin improved more than 1,000 percent.

Overall, Vertex reported revenues of more than $98 million, with profits exceeding last year’s figure by over $5 million, and a gross profit margin 10 percent higher than in 2015. During 2016, the company reduced debts and stabilized itself. VTNR expects increased volume in 2017.

Recently, analysts have shown significant interest in Vertex Energy, with the majority of these offering the company a ‘Buy’ or ‘Strong Buy’ recommendation on the stock. Rives Journal states that some analysts project the stock to reach $2.13 in the near future (http://dtn.fm/0NnCI). Zacks Investment Research upgraded Vertex from a ‘Hold’ rating to a ‘Buy’ rating with a price objective of $1.50 per share, all according to Daily Quint (http://dtn.fm/zGd6B).

Institutional investors raised their positions in the company, giving them ownership of 21.51 percent of Vertex’s stock. On March 1, 2017, Vertex Energy traded up over 4 percent, reaching $1.41. As it stands today, the company has a market cap of just over $39 million.

For more information, visit www.VertexEnergy.com

eMagin Corp. (NYSE: EMAN) Set to Capitalize On the Growing Head Mounted Display Market

According to a new market report published by Credence Research (http://dtn.fm/FV2Gi) entitled ‘Head Mounted Display (HMD) (Defense, Consumer, Industrial, Healthcare, Public Safety, and Other Verticals) Market – Growth, Share, Opportunities, Competitive Analysis, and Forecast 2015 – 2022’, the head mounted display market is expected to expand at a compound annual growth rate of just below 50% between 2015 and 2022.

The report explains that this significant growth has been largely attributed to the declining prices of microdisplays, coupled with the high demand for lightweight wearable computing devices. Because of this decline in prices, manufacturers are now able to penetrate into the consumer market, offering more affordable products.

eMagin Corp. (NYSE MKT: EMAN), a company dedicated to developing and delivering head-worn systems for law enforcement, military, entertainment, and medical applications, among others, is set to capitalize on this growing industry thanks to its ability to develop and deliver high-quality, high-resolution, cutting-edge displays to its customers.

Earlier this week, the company was a big mover, with a rise in shares of more than 9% on March 7, 2017. According to the Nasdaq website (http://dtn.fm/YhZ6q), “The move came on solid volume with far more shares changing hands than in a normal session. This breaks the recent trend of the company, as the stock is now trading above the volatile price range of $2.10 to $2.30 in the past one-month time frame.” The company’s stock price escalated, climbing to $2.45 per share in Friday morning trading.

On March 8, the Daily Quint reported that Bessemer Group, Inc. had acquired over 76,000 new shares of eMagin stock worth approximately $164,000 (http://dtn.fm/9QusN). Not only this, Fiscal Standard (http://dtn.fm/l8xRG) reported that H. C. Wainright and Craig Hallum began coverage on the company, with both issuing it a ‘Buy’ rating. Craig Hallum gave eMagin a target share price of $6.

eMagin is the first and leading manufacturer of active matrix OLED-on-silicon microdisplays. In addition to the company’s focus on the security, defense, medical, and industrial markets, eMagin has now entered into the consumer market with its Z800 3DVisor, which was described as the “the best 3D goggles we’ve ever tested” by Maximum PC (http://dtn.fm/zyV67).

For more information, visit www.eMagin.com

SolarWindow Technologies, Inc. (WNDW) Named a 2017 BIG Innovations Award Winner by Business Intelligence Group

March 8, 2017

SolarWindow Technologies, Inc. (OTCQB: WNDW), on February 7, 2017, was named as a winner in the 2017 BIG Innovations Awards presented by the Business Intelligence Group (http://dtn.fm/Nb3Yd), an organization of business executives who utilize a proprietary formula to recognize superior performance. The company is a technology firm that develops transparent, electricity-generating coatings for windows on tall towers. Its product was one of only four named a ‘shining star’ of innovation and a Chairman’s Choice winner.

The coatings supplied by SolarWindow Technologies, Inc. have the potential to turn a skyscraper into a ‘clean power generator’, the company announced. Its veneers can generate electricity using either natural or artificial light, in shaded areas, and even reflected and diffused light. They can be applied to all sides of a tall building, and they’re capable of realizing electricity savings of up to 50% annually, the company said, noting that it could return a one-year financial payback. This potential return was validated by independent engineering studies, according to SolarWindow.

The coatings are designed to produce electricity through transparent and organic photovoltaic (PV) coatings applied to the glass and flexible plastic for applications to tall buildings. As a result, normally passive windows are transformed into electricity producers. The potential one-year payback has been seen on a 50-story building. The company’s technology can also provide more than 15 times the environmental benefits of a conventional solar rooftop PV system.

In a news release, Maria Jimenez, chief operating officer of the Business Intelligence Group, said, “We are thrilled to be honoring SolarWindow as they are leading by example and making real progress on improving the daily lives of so many.”

John A. Conklin, president and CEO of SolarWindow, added, “We are honored to be recognized by this distinguished panel of business leaders for our work in developing possibly the biggest single breakthrough in clean energy — converting the solar rays of the sun into electricity on skyscrapers the world over.”

For more information, visit www.SolarWindow.com

Advanced Medical Isotope Corp. (ADMD) is “One to Watch”

Advanced Medical Isotope Corporation (OTC: ADMD), a late-stage radiation oncology-focused medical device company, has developed a real power play portfolio in the radiotherapy segment of the cancer treatment market, a niche set to hit $11.3 billion on its own by 2025 globally, growing at an estimated 6.7 percent CAGR. Brachytherapy, or placing radioactive implants directly on or into cancerous tissue, is a component of this sector; however, brachytherapy hasn’t seen the kind of traction historically that an innovator like ADMD stands poised to wrest out of it. The brachytherapy market ran about $705 million in 2015 and consisted of a 60/40 mix between HDR/LDR (high- and low-dose radiation) or pulsed therapies on the one hand, and microsphere brachytherapy on the other.

A Market Ripe for Disruption

Even with somewhat innovative developments like microspheres helping to drive growth estimates of some eight percent CAGR for the overall brachytherapy space, and projections of $2 billion by 2030, only ten or so companies currently dominate this heavily consolidated space. Most microsphere solutions pose migration risk, require pretreatment of the patient (which only somewhat mitigates the migration problem), and carry similar risks to other radiotherapies when it comes to the overall impact to surrounding healthy tissues. Microspheres are also typically quite limited in terms of what types of cancers/tissue systems they can effectively address, with liver cancer treatments like Australian company Sirtex’s (OTC: SXMDF) SIR-Spheres® being the obvious analogy.

This is where a company like ADMD really stands out from the competition with its Yttrium-90 (Y-90) based radiotherapy solutions, such as the Y-90 RadioGel™ device (ruled a medical device by the FDA in 2013) which is a highly localized direct delivery technology that is injected into the tumor. Y-90 RadioGel delivers an exceptional therapeutic ratio (high degree of dose delivered to cancer tissues, relative to impact on normal tissues) thanks to Y-90’s short-range, which effectively delimits radiation impact to surrounding tissues. RadioGel promises to offer a superior therapeutic profile compared to existing solutions in the brachytherapy segment, even innovations such as Y-90 microspheres that pose significant migration risks, and thus still carry the standard risk to normal surrounding tissues.

Unlike more expensive brachytherapy industry standard isotopes such as Cesium-131, Iodine-125, or Palladium-103 (which primarily emit auger x-rays of an infinite path length, use complex/costly delivery systems, and have a half-life ranging from 9.7 to 60 days), Yttrium-90 has a very short path length of only 4mm, a half-life of just 2.7 days, and is considerably less expensive/more accessible. This means Y-90 solutions are much safer to handle for healthcare professionals, treatment times are sizably reduced, and huge cost savings can find their way to the consumer. Perhaps most importantly though, is the earlier point about how Y-90 RadioGel is not limited to a handful of tumor/cancer types, as is the case with most microsphere or seed-based brachytherapy products.

Tech Portfolio Coverage Hints at Upper Limit Potential

Not content to rest on the laurels of a brachytherapy device like RadioGel, which obliterates the migration problem and has shown in studies that greater than 99 percent of the radiation stays in the tumor, the company has also developed a new approach to so-called permanent seed brachytherapy as well. ADMD’s Y-90 Fast-Resorbable Polymer Seeds (which contain RadioGel), unlike the industry standard glass or titanium seeds (which are packed with radioactive material and then injected to the tumor site), are fully resorbable/biodegradable and leave no casing behind.

The contrast couldn’t be more apparent between these proprietary polymer seeds containing RadioGel, and standard permanent seed therapy in the typical use scenario of prostate cancer. The RadioGel-containing polymer seeds are administered via a minimally invasive procedure that only requires small-gauge needles, whereas the standard permanent seed therapy uses up to 30 large needles, which inject seeds whose casings are left behind. Put yourself in the shoes of a patient for even five seconds and the contrast becomes glaringly obvious.

ADMD has even developed a Y-90 Polymer Topical Paste product engineered for direct application to tissues after a tumor resection, where it works hard to kill off any residual tumor cells that got missed during the surgery. This is an important product due to the constant fear of cancer recurrence, which has been a PR black-eye for the oncology community, and is indeed quite devastating to brave cancer survivors. Going through all the cost, suffering, and difficulties of cancer treatment, only to have the cancer come back, is a living nightmare that is all too common among cancer patients.

The short-range beta radiation emitted by Y-90 particles offers such high therapeutic index possibilities that the products ADMD has developed could even help to gradually reshape the standards of care within the broader cancer treatment market. And brachytherapy, one of the oldest known approaches to radiotherapy, could see a big, big resurgence. The company has exclusively licensed the Y-90 polymer composite tech (which was developed at Pacific Northwest National Laboratory) from the legendary Battelle Memorial Institute, one of the top government/commercial research institutes in the world.

ADMD is On the March, Pet Oncology is the Spear Tip

The company achieved an important milestone in late February 2017 with its fourth letter in a series of communications with the FDA, wherein the company identifies skin cancer (basal cell and squamous) as the primary indication via which RadioGel will be pushed towards FDA submittal and commercialization. An excellent choice given the laborious complexities of skin cancer surgeries and their post-op complications. These issues are particularly vexing for elderly patients, who have skin that is usually significantly thinner and much less robust.

With some 3.3 million or more skin cancer patients in the U.S. alone, many of whom have more than one tumor, it is reasonable to assert that the superior therapeutic profile of ADMD’s RadioGel could see the product rapidly become the indication of choice preferred by both patients and healthcare professionals alike. Looking at the technology portfolio here and the broad range of cancer types that can be treated using ADMD’s products, it should be tantalizing to investors just how much of the roughly $113 billion global cancer therapy market the company could eventually gobble up. Particularly when one considers the 7.4 percent CAGR projections for the industry as a whole through 2021. Post-commercialization, once the word about this technology really starts getting out to consumers, ADMD could be sitting on a gold mine.

The company also released a key letter to shareholders in February, mapping the new and streamlined path forward to FDA submission, which also contained a more formal introduction of new management appointed at the end of 2016. It included the appointment of a new CEO by the Board of Directors, Dr. Michael Korenko, and the appointment of Dr. Carlton Cadwell as Chairman. It’s a serious move by ADMD to show the FDA that they are not only listening, but taking guidance as gospel.

As a prominent indicator of just how aggressive the company really is about commercialization, one need only look at its emphasis on the veterinary oncology market. This is something of an open trade secret these days in biopharma: if you want to rapid-prototype your way into human use as a novel medical device developer, on-ramp via the pet market (if you are lucky enough to be able to).

Advanced Medical Isotope Corporation’s wholly-owned IsoPet Solutions subsidiary just announced late last year in October that the first animal, a cat, had received initial treatment with the pet version of the Y-90 RadioGel. This study will generate important data and help to advance the product towards commercialization in the veterinary market, paving the way for longer-term human use approval by the FDA. This is an exciting forward vector for the company, given the Trump administration’s vow in February to massively overhaul the FDA, with an emphasis on speeding up the pace at which new drugs come to market.

Looking at just the veterinary oncology market we have a winning proposition with ADMD’s Y-90 tech portfolio, given that roughly half of all dogs and around one third of all cats will be diagnosed with cancer in their lifetime. There are around 85.8 million cats and 77.8 million dogs in the country and we now live in an age where pets are essentially bonafide members of the family. The preceding statistic should color the likely much broader incident rate of undiagnosed cancers in cats and dogs, and throw light on the comparatively much cheaper/effective radiotherapy solutions ADMD is developing. Cancer is the leading cause of mortality in cats and dogs alike, with the average radiation treatment for dogs currently costing from around $5,000 to $7,000.

People love their pets but that is a hefty price tag for the average consumer. IsoPet Solutions could place effective pet cancer treatment for a broad range of caner types well within comfortable striking distance for millions of average consumer households. Ask around, comprehensive cancer treatment for pets is simply not doable for most people today, as the average pet owner simply cannot afford to shell out that kind of capital, even for a cherished pet whom they consider a genuine member of the family. The PR upside for ADMD on this subject alone basically writes itself. As an investor, one can just imagine the publicity boon from being able to make such a boast to pet owners, as having an effective/affordable cancer treatment to save the lives of their cats and dogs.

The proven efficacy of radioisotopes for melting cancer in a localized fashion, further hyper-localized and made safer by the company in terms of impact to surrounding tissues, is an easy sell. ADMD is a very interesting play in the oncology space with some serious potential due to broad spectrum applicability of the tech, and is currently trading near the bottom of the 52-week range ($0.07 to $1.00) at approximately $0.15/share.

To take a closer look, visit https://www.isotopeworld.com and http://www.isopetsolutions.com

Ring Energy, Inc. (REI) Rebounds from Lows and Increases Production

March 7, 2017

Oil and gas company stocks have taken a beating as oil prices have tumbled from a peak of over $100 in 2014 to around $50 a barrel today. This fall in prices crippled many exploration and production companies. Down from its peak of nearly $20 per share in 2014, Ring Energy, Inc. (NYSE MKT: REI) is still in a better position than most. Unlike other drillers, Ring Energy isn’t highly leveraged and has comparatively low production costs.

Ring Energy has stated that it could operate profitably under $60 per barrel, and the majority of the company’s crude production is based in the Permian Basin, which has fewer bottlenecks than the Bakken Formation. In its January 9, 2017, press release, the company reported “net production for the fourth quarter of 2016 was approximately 240,000 BOEs (Barrel of Oil Equivalent), as compared to net production of 218,500 BOEs for the same quarter in 2015, an approximate 10% increase, and net production of 209,000 for the third quarter of 2016, an approximate 15% increase… For the twelve months ended December 31, 2016, net production was approximately 865,500 BOE, as compared to 742,070 for the twelve months ended December 31, 2015, an approximate 16% increase.” The company’s low production costs and the increase in production has correlated into its share price more than doubling over the last year.

Ring Energy’s exploration and production interests focus primarily on Texas and Kansas. The company’s drilling operations target the Central Basin Platform in Andrews and Gaines Counties, Texas, and the Delaware Basin in Reeves and Culberson Counties, Texas. The company has proved reserves of approximately 24 million BOE.

Oil has certainly been on a ride the last few years, but it’s still an essential commodity that will continue to drive the world economy. Ring Energy has weathered the oil price collapse. Any further increase in oil prices, combined with the company’s cost cutting and increased production, should provide both topline and bottom line lift in the coming quarters.

For more information, visit www.RingEnergy.com

MediWound (NASDAQ: MDWD) to Extend Label for Pineapple Drug to Larger Burns

March 3, 2017

When Christopher Columbus introduced the pineapple to Europe in the late fifteenth century, he undoubtedly would have had no idea that extracts from the plant could be used to treat severe thermal burns. Yet, 500 years later, a next-generation proteolytic enzyme platform for wound debridement, NexoBrid, derived from pineapples, has been developed by MediWound Ltd. (NASDAQ: MDWD). Now, positive results from a Phase II study evaluating NexoBrid will be used to support a request to the Food and Drug Administration (FDA) and the European Medicines Agency (EMA) to extend the label for NexoBrid to larger burns. The painstaking research undertaken by niche specialty biotech MediWound is beginning to bear fruit.

That research has laid bare one ‘secret’ of the medicine practiced traditionally by natives of South and Central America and developed on it to improve the treatment of wounds. Pineapples, it turns out, are a rich source of proteolytic enzymes, referred to generally as bromelain, which promote healing in wounds by stimulating debridement, the removal of dead tissue and foreign material. Proteolytic enzymes remove this necrotic tissue, known as eschar, at a much faster rate than would occur otherwise. To harness this powerful chemical process, MediWound has developed its proteolytic enzyme platform. NexoBrid is a concentrate derived from a mixture of proteolytic enzymes extracted from the stem of the pineapple plant, enriched in bromelain. The drug is indicated for removal of eschar in adults with deep partial- and full-thickness thermal burns.

Last month, MediWound announced positive results from a Phase II study that evaluated the safety, pharmacokinetics (transcutaneous absorption) and efficacy of NexoBrid in hospitalized children and adults with severe thermal burns. The multicenter, open-label, single-arm study was conducted in Europe, Israel and India and included 36 patients with severe burns of 4 percent to 30 percent total body surface area (TBSA).

NexoBrid was applied to burns of up to 15 percent TBSA in one session, and when the wound area to be treated was more than 15% TBSA, NexoBrid was applied in two separate sessions, each up to 15 percent TBSA. Trial results showed that the use of NexoBrid was safe and effective. Furthermore, the pharmacokinetic profile following NexoBrid’s first and second topical application was comparable, suggesting no concern with accumulation following a second topical application of NexoBrid. As a result, the company intends to send requests to the FDA and EMA to extend the label for NexoBrid to larger burns.

MediWound is a fully integrated biopharmaceutical company focused on developing, manufacturing and commercializing novel therapeutics based on its patented proteolytic enzyme technology to address unmet needs in the fields of severe burns, as well as chronic and other hard-to-heal wounds. Its first innovative biopharmaceutical product, NexoBrid, received marketing authorization from the European Medicines Agency for removal of dead or damaged tissue, known as eschar, in adults with deep partial- and full-thickness thermal burns and has already been launched in Europe.

MediWound’s second innovative product, EscharEx®, is a topical biological drug being developed for debridement of chronic and other hard-to-heal wounds, a large and growing market. EscharEx® is complementary to the large number of existing wound healing products, which require a clean wound bed in order to heal the wound. EscharEx®contains the same proteolytic enzyme technology as NexoBrid® and benefits from the wealth of existing development data on NexoBrid®.

Aegis Capital, which initiated coverage on MediWound late last year, has issued a ‘Buy’ rating on the stock, setting a price target of $11.00. The stock, under the symbol MDWD, currently trades on the NASDAQ at around $6.00.

For more information, visit www.MediWound.com

India Globalization Capital, Inc. (NYSE MKT: IGC) Targets Cannabis-Based Pharmaceuticals

March 2, 2017

India Globalization Capital, Inc. (NYSE MKT: IGC) is a company in transition, now targeting pharmaceutical development in the U.S., while curtailing other businesses such as electronics trading in Hong Kong. IGC long-term plans are to establish and extend its development of phytocannabinoid-based pharmaceutical products to treat diseases such as epilepsy and cachexia. The company expects to file more patents and develop additional intellectual property in the health care industry.

In the U.S., IGC develops phytocannabinoid-based treatments for epilepsy, seizures and cachexia. The goal in 2017, per CEO Ram Mukunda, is for the company to expand its cannabis-based portfolio, indicating that IGC will begin preclinical trials of IGC-501-Pain, IGC-502-Seizures and IGC-504-Cachexia (http://dtn.fm/bv91H). The company has formed a Phytocannabinoid Development Committee to review global medical facilities prior to beginning its preclinical trials. Toxicity evaluation and pharmacological assessments will be performed on each compound in preclinical trials.

Based in Bethesda, Maryland, IGC also manages real estate, leasing and development of properties. In India, it leases heavy equipment. In Malaysia, it manages commercial and residential real estate. In Hong Kong, the company previously operated a electronics business, but it has subsequently moved away from that activity. Long term, IGC aims to establish itself as a specialty pharmaceutical provider. It has already filed five provisional patents for its phytocannabinoid-based pharmaceutical and nutraceutical products in the U.S.

For more information, please refer to www.IGCInc.us

Pressure BioSciences, Inc. (PBIO) Receives New Instrument Award from Corporate America News Magazine

On Wednesday, Pressure BioSciences, Inc. (OTCQB: PBIO) announced that it has received the award for ‘Best New Instrument For Sample Preparation 2017’ from Corporate America News (http://dtn.fm/CAg47) for its Barocycler 2320Extreme.

The unit is the most recent product added to PBIO’s Barocycler line. It is a smaller device designed for preparing protein samples for review. It is sold to the life science market, which is valued at roughly $6 billion, according to industry data.

Pressure BioSciences, Inc. develops and sells laboratory instrumentation. It manufactures products in static and alternating pressure. The company says it has installed more than 250 of its systems in 160 sites globally. While its focus is on forensics and biomarker discovery, its products are also utilized in vaccine manufacturing and drug discovery, design and histology.

The award was given to PBIO by Corporate America News as part of its 2017 North American Excellence Awards. Targeting the U.S. business market, the magazine has a circulation of some 135,000.

“We are honored to have been selected for this prestigious award,” Dr. Nate Lawrence, PBIO’s VP of marketing and sales, stated in a news release. “It was just eight months ago when we launched this next-generation Barocycler instrument, the EXT 2320. Since then, the instrument has been purchased by key scientists in academic, government, biotech and pharma labs worldwide, including institutions involved in the Cancer Moonshot Initiative. We believe this award affirms the significant potential of the Barocycler 2320.”

Richard T. Shumacher, president and CEO of PBIO, described in the magazine the specific features and benefits of the Barocycler 2320Extreme. He also discussed the history of the company and its future growth potential.

“In addition to our patented and cutting edge technology platform, we have both a hard-working, results-driven management and support team, and an experienced and supportive Board of Directors,” Shumacher said. “We believe that the combination of these factors will help ensure the success of our company with a concomitant strong return-on-investment for stakeholders in [PBIO].”

For more information, visit www.PressureBiosciences.com

Axim Biotechnologies (AXIM) Boosts Billion-Dollar Brand Portfolio with Launch of CanChew Plus™

Now that production of its next generation award-winning controlled-release cannabidiol (CBD) functional chewing gum, CanChew Plus™, has kicked off, Axim Biotechnologies (OTCQB: AXIM) has boosted its diverse billion-dollar product portfolio with another strong growth brand. With so many golden eggs in its brand basket, the company is expecting strong top line growth in the near future. Current revenue projections show AXIM could soon earn the rarified rank of unicorn.

AXIM is looking ahead to a bright future with an uplisting to either the NYSE or NASDAQ. The company’s strong sales projections are built on a number of factors. The company’s vertically-integrated supply chain speeds up logistics and reduces costs. It also facilitates full manufacturing capabilities at facilities in Almere in The Netherlands. AXIM has a healthy intellectual property (IP) portfolio that includes over 10 patents and over 20 trademarks, and the company has close to 20 products in various developmental stages.

AXIM’s product line is based on hemp, a cousin to marijuana classified under the same botanical category of cannabis sativa. The major difference between the two is that marijuana has significant amounts of tetrahydrocannabinol (THC) (5–20%), a psychotropic cannabinoid that will get you ‘high’. Hemp, on the other hand, has virtually no THC (less than 0.3%), but it is rich in cannabidiol (CBD) and cannabigerol (CBG).

Both CBD and CBG appear to offer benefits in treating some medical conditions. The AXIM product pipeline includes drug candidates to treat multiple sclerosis/pain spasticity, Parkinson’s disease, dementia, restless legs syndrome (RLS), Crohn’s disease, opioid addiction/cannabis dependence, tobacco smoking cessation, post-herpetic neuralgia, irritable bowel syndrome (IBS), inflammatory bowel disease, psoriasis/atopic dermatitis, glaucoma, and dry eye.

CanChew®, which contains 50 mg of hemp oil and 10 mg of CBD, is meant to alleviate IBS and inflammatory bowel disease. It is the world’s first patented controlled-release cannabinoid chewing gum. The new formulation, CanChew Plus™, contains the same active ingredients and is 60 percent smaller than the original CanChew® gums for an improved chewing experience. In addition, CanChew Plus™ offers an improved oral mucosal delivery system through microencapsulation that increases the bioavailability of the active ingredient from less than 50 percent, with CanChew®, to an absorption rate of 80 percent of CBD, after just 30 minutes of chewing.

In 2017, Axim plans to release CanChew® chewing gum as a food supplement. The company also intends to initiate a number of clinical studies for the product, including its evaluation in treating chronic pain and spasticity in patients with multiple sclerosis.

Currently trading at just under $10.00, the stock, under the symbol AXIM, peaked at $19.00 earlier this year. The folks at Motley Fool think it’s a good bet (http://dtn.fm/RK2ew), surmising that ‘investors were excited about the potential for Axim’s hemp-based chewing gum.’ They also called it ‘one of the best marijuana stocks this year’ in a 2016 report. Axim might just repeat that performance in 2017.

For more information, visit www.AximBiotech.com

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